Why postbiotics can improve your health: definition, benefits and side-effects

Last year we encountered an interesting product released by NOW , which is called EpiCor Immunity. Sadly it didn't really catch the attention of our customer base. However, more recently Vitals, a Dutch supplement company released a new product called PostBiol and to our surprise also contains EpiCor. Somehow we had overlooked the fact Epicor is a postbiotic.

Even though we've been into pre- and probiotics for years , neither of us had heard of postbiotics nor did we know EpiCor is apparently one such postbiotic. If we hadn't heard about postbiotics before, it's highly likely that you don't know of its existence either.

In light of COVID-19, a good number of consumers are searching for ways to boost their immune health. It’s common knowledge that diet is linked to health, and this is especially true for the health of the immune system. In fact, there is a direct link between gut health and immunity because most of the immune system is in the intestines.

But now we can go one step further to 'pamper' our gut microbiome and ingest postbiotics.

What are postbiotics?

While knowledge about the benefits associated with probiotics has exploded over the past decade, many people are still unsure about how prebiotics and postbiotics work. Probiotics are the “good” (or “friendly”) bacteria that colonize the digestive system and support many functions of the immune system.

Prebiotics (mostly fibers) essentially feed probiotics, helping them survive and reproduce through the process of fermentation.

But what are postbiotics? Postbiotics are produced as a byproduct of the fermentation process carried out by probiotics. Examples include organic acids, bacteriocins, carbonic substances and enzymes.

One of the first definitions of postbiotics was given in 2014 in the Journal of Gastroenterology:

"Probiotics are alive non-pathogenic microorganisms present in the gut microbiota that confer benefits to the host for his health. Some of these beneficial effects are determined by secreted probiotic-derived factors that recently have been identified as postbiotic mediators."

Researchers now believe that for certain people suffering from inflammatory conditions, the use of postbiotics may be a smart alternative to the use of whole bacteria (in probiotic form). Due to their ability to decrease inflammation and help maintain colonic and intestinal homeostasis, postbiotics might be the next wave of supplements used to foster better gut health.

Postbiotics are byproducts of probiotic bacterial fermentation. When probiotics feed on certain types of fiber molecules in order to thrive, they leave behind “waste products” that are collectively called postbiotics.
The microbiota therefore naturally releases postbiotics, which in turn help regulate the composition of the microbiome.

Being a waste product might not sound too impressive, but more research is now showing that postbiotics might play an essential role in gut health. According to the Postbiotica website, an organization that’s affiliated with the University of Milan, “most of the immunomodulatory activities of bacteria are associated to their metabolites.”

Benefits of postbioticis

Benefits associated with postbiotics include helping treat:

• inflammatory conditions including irritable bowel disease (IBD) or irritable bowel syndrome (IBS)
• side effects due to obesity
• allergic reactions, such as dermatitis or conjunctivitis
• gut-related problems such as leaky gut syndrome, dysbiosis or small intestine bacterial overgrowth (SIBO)
• joint pain due to inflammation
• diabetes and prediabetes
• eye problems, including allergic conjunctivitis
• side effects due to exposure to environmental irritants
• skin problems, including acne or eczema
• veterinary uses

While there’s still more to learn about how exactly postbiotics contribute to homeostasis, they seem to help regulate the microbiota via anti-pathogenic activities and supporting growth of beneficial bacteria. They also seem to help the immune system adapt to changes in gut bacteria by having regulatory effects.

Researchers at Probiotica explain that compared to taking probiotics, using postbiotics may have certain advantages. These include the fact that they don’t contain any harmful bacterial components, they’re considered very safe, they don’t require the need for bacterial growth or colonization in the host (the person taking the product), they can be used in lower concentrations, and they may contain higher amounts of active components.

Examples of postbiotics include:

• short-chain fatty acids, such as acetate, butyrate and propionate. These are produced by fermenting undigested carbohydrates in the intestine. These fatty acids provide a major energy source for the colon and play a role in intestinal growth and differentiation. They impact many metabolic processes.
• lipopolysaccharides, including polysaccharide A and exopolysaccharide
• muramyl dipeptide
• indole, derived from tryptophan
• teichoic acid
• lactocepin
• p40 molecule

Prebiotics, probiotics and postbiotics

The body is home to trillions of gut bacteria, which together are called the microbiome. Another name for this bacterial community is the microbiota, the large collection of microorganisms that live in symbiosis within the human body. There are three main categories of bacterial components/substances that help keep the microbiota in balance. These include:

1. Prebiotics
2. Probiotics
3. Postbiotics

Bacteria that make up the microbiome are capable of sending inflammatory signals to the brain and elsewhere throughout the body, changing how food is digested, how hormones are produced, how capable insulin is of lowering glucose in the blood and many other functions.

When pathogens take over the microbiome, dysbiosis occurs. This is associated with problems like diarrhea, allergies, IBS or IBD, and many others. Often these problems are treated with medications including anti-inflammatory or immunomodulatory drugs. However, these can cause side effects.

1. Prebiotics are types of soluble fiber molecules found in certain carbohydrates, especially those that are starchy. Their main role is to nurture probiotics by supplying them with energy, as probiotics feed on prebiotics through a process of fermentation. They’re undigestible by humans, meaning they pass through the human digestive system without being broken down or absorbed until they reach the lower part of the large intestines.

Types of prebiotics include oligosaccharides, arabinogalactans, fructooligosaccharides and inulin. The best prebiotic foods sources are plant foods like root veggies, certain under-ripe fruits, grains and legumes. Include more high-fiber foods in your diet to increase your intake of prebiotic compounds, such as raw garlic, Jerusalem artichokes, jicama, dandelion greens, raw onions, raw asparagus and under-ripe (slightly green) bananas.

2. Probiotics are supplements or foods that contain viable microorganisms that alter the microflora of the host. Examples include bifidobacteria, lactobacillus and bacteroides. Probiotic bacteria have numerous roles, some of which include promoting intestinal barrier function, regulating inflammation, generating reactive oxygen species, regulating apoptosis (cell death), and helping with hormone and neurotransmitter production.

Live probiotic bacteria can be taken in supplement form, including as pills, powders or liquids. Additionally, certain fermented foods naturally contain probiotics, including yogurt, kefir, and cultured veggies like sauerkraut or kimchi.

When probiotics are combined with prebiotics, they’re often called synbiotics. These products may offer the most benefits due to how the prebiotics support growth of the probiotics.

Health benefits of postbiotics

1. Help support growth of probiotic “good” bacteria

Postbiotics are produced during metabolic processes carried out by lactic acid bacteria. They can mimic activities of probiotics in certain ways, in addition to helping probiotics thrive. Lactic acid bacteria that are supported by postbiotics have many benefits within the microbiome, including helping remove heavy metals from the body and decreasing the presence of viruses and toxins.

One of the most promising things about using postbiotics in place of probiotics is due to how postbiotics mimic the beneficial and therapeutic effects of probiotics while avoiding the risk of administering live microorganisms to patients who cannot tolerate them, such as those with immature intestinal barriers or impaired immune defenses.

Additionally, there’s some evidence that probiotic bacteria that are killed due to heat in the gastrointestinal tract may function as postbiotics. These microorganisms seem to retain their structure and continue to have beneficial effects on the host, such as accelerating intestinal barrier maturation and healing.

2. Reduce the presence of harmful pathogens

The body is home to both beneficial and harmful bacteria. Some natural substances — including certain herbs and plants — have antimicrobial properties, allowing them to diminish harmful bacteria and therefore helping prevent infections and illnesses. Researchers believe that postbiotics may have some of the same antimicrobrial abilities, which is why it’s speculated that postbiotics may be the next frontier in supporting the immune system against pathogens.

Some of the pathogens that postbiotics may be capable of diminishing include listeria monocytogenes, clostridium perfringens, salmonella enterica, and escherichia coli.

3. Help lower inflammatory diseases and oxidative stress

Studies have found that probiotic bacteria, including lactobacillus casei DG (LC-DG), produce beneficial postbiotic byproducts that together help modulate inflammatory/immune responses.
In studies. postbiotics — such as the fatty acids called acetate, butyrate and propionate — have been linked to inflammatory suppression, reduced generation of reactive oxygen species and regulation of apoptosis.

Due to their ability to decrease inflammation, such as after someone has recovered from an illness or infection, probiotics and postbiotics together can be helpful for treating symptoms of IBS and IBD, in addition to many other inflammatory conditions. Some research even shows that in certain cases when probiotics are not helpful or necessarily safe to give to patients with inflamed GI tissue, “Postbiotics may be a safe alternative for the treatment of patients with IBD in the acute inflammatory phase.”

4. May help lower blood sugar and prevent diabetes

A recent study done at McMaster University in Canada found that use of postbiotics is associated with reductions in blood sugar levels in obese individuals who have prediabetes. Postbiotics seem to have anti-diabetic effects because they improve the body’s use of insulin.
Research suggests that postbiotics’ mechanisms of action include reducing fat inflammation and decreasing liver insulin resistance.

Mice that were injected with the type of postbiotic called muramyl dipeptide experienced reduced adipose (fat) inflammation and reduced glucose intolerance even without losing any weight. Based on the study findings, certain postbiotics are therefore considered to be “insulin sensitizers” with various protective effects in obese or diabetic patients.

5. Well-tolerated by those with suppressed immune systems (including infants)

Studies have found that probiotics are effective in decreasing necrotizing enterocolitis (NEC), a serious health condition that is one of the leading causes of complications and death in preterm infants. NEC is characterized by intestinal injury and inflammation. It develops in about one out of 10 preterm infants and is considered a medical emergency.

While probiotics are currently considered “the most promising therapy on the horizon for this devastating disease,” researchers are now turning to prebiotics and postbiotics as potential alternatives or adjunctive therapies to probiotics. Probiotic and postbiotic bacteria are essential infants for digestion, absorption, storage of nutrients, development and immunity (just like they are in adults). Some infants cannot tolerate supplementing with live microorganisms (probiotic bacteria) but may respond well to prebiotics and postbiotics.

A 2014 report published in Clinics in Perinatology explains: “The infant/host provides an hospitable, temperature-stable, nutrient-rich environment for bacteria while receiving, in return, benefits from the commensal bacteria.”
Postbiotics may help the infant’s intestine protect itself from bacterial pathogens that cause inflammation, encourage the growth of beneficial bacteria, control epithelial immune responses and maintain intestinal homeostasis.

Postbiotics made from Saccharomyces cerevisia

The unicellular yeast Saccharomyces cerevisiae (baker's or brewer's yeast) is well known as a starter culture for fermented foods such as wine, beer, cider, sake and bread. The yeast may also be beneficial for health.
Several strains of Saccharomyces cerevisiae are classified as probiotics and have immune enhancing, immunomodulatory, anti-inflammatory, antimicrobial and antioxidant properties, provide nutrients and strengthen the intestinal epithelium.

Certain strains of Saccharomyces cerevisiae are also used for production of postbiotics.
EpiCor, hereinafter referred to as (dried) yeast fermentate, is a patented postbiotic of (non-genetically modified) Saccharomyces cerevisiae, which has US GRAS (Generally Recognized as Safe) status and is pH and heat stable.
In addition to non-living yeast cells, the dried yeast fermentation contains proteins, peptides, antioxidants, B vitamins, minerals, fatty acids, polyphenols (including resveratrol), phospholipids, organic acids, soluble and insoluble fibres, nucleotides, sterols, polysaccharides (beta-1 ,3/1,6-glucans) and mannans (polymers of mannose) in a unique, constant composition.
In human studies with this yeast fermentate, a daily dose of 500 mg has been shown to be beneficial.

Human studies with dried yeast fermentate
Yeast fermentate makes workers less ill.
In a US production facility where a health-promoting yeast fermentate is made for livestock, decades later it was noticed that workers who worked with the yeast fermentate and who presumably consumed some of the yeast fermentate through ingestion or inhalation appeared healthier , reported sick less often and had significantly less flu than employees who had other activities within the company.This led to examination of the blood and saliva of both groups of employees, which showed that exposure to the yeast fermentate had beneficial effects on the antioxidant status and immune system.
Long-term exposure to the yeast fermentate led, among other things, to an increased activity of Natural Killer cells, which are are important for fighting cancer and viral infections. But also a higher level of the antioxidant glutathione in red blood cells and more IgA (immunoglobulin A) in saliva.
In addition, the antioxidant activity in blood was higher and the phagocytic activity of macrophages was greater.
Immune cells were (ex-vivo) better able to kill tumor cells and virus-infected cells and to fight the E.coli (Escherichia coli) bacteria. These findings prompted the development of EpiCor.

Risks and side effects

While use of prebiotics, probiotics and postbiotics can certainly make a big difference in terms of improving digestive health and other symptoms, simply taking these in supplement form likely won’t be enough to solve all your problems.

These treatments work best when combined with lifestyle changes, especially eating a healthy diet, reducing intake of toxins or unnecessary medications, and controlling stress.

Remember that when it comes to supporting your microbiome and maintaining a healthy gut, keep your eye on the big picture. Eat a nutrient-dense diet, limit or avoid processed foods, and consider other lifestyle changes that you can afford to make in order to better your health.

Top sources

For the most part, postbiotic supplements are still not widely available, especially compared to the number of probiotic products on the market. Look for postbiotic products that include a number of different types of postbiotics, especially short-chain fatty acids. Quite often, rather than being labeled “postbiotics,” they may have another name like sodium butyrate, calcium butyrate, or dried yeast fermentate.


You can also naturally increase your production of postbiotics by including certain foods in your diet, especially those with prebiotics and probiotics.
Prebiotic food sources are: chicory root,garlic, onions, leeks, asparagus, barley, oats, flaxseed, seaweed
Probiotic food sources are: yogurt with live cultures, kefir, sauerkraut, kimchi, miso, tempeh, kombucha

Food supplements that can boost postbiotic concentration include:

• Spirulina and chlorella — Types of algae that help detox the body, reduce inflammation, feed beneficial bacteria and possibly help increase secretory immunoglobulin A, which improves gut health.
• Mycelium, which produces mushrooms — Mycelium contains many enzymes, antimicrobial agents, antiviral compounds, in addition to supporting bacterial growth in the microbiome.
• Grape pomace — The solid remains of grapes, olives or other fruit that contains skins, pulp, seeds and stems of the fruit. These provide energy for probiotics, which in turn boosts postbiotics.
• Fermented aloe — Helps with detoxification, digestive support and producing immune-boosting beta-glucans.
• Shilajit — An ancient herb with anti-inflammatory compounds, antiviral activity and high fulvic acid content.
• Apple cider vinegar and coconut vinegar
• Humic and fulvic acids
• Bacterial protease — A collection of enzymes that supports the immune system, helps lower pathogens, helps the body deal with stress and improves gut health.
• Saccharomyces enzymes — Support healthy digestion, many metabolic processes, and breakdown of fats, carbohydrates and protein.

Conclusion

Postbiotics are bioactive compounds made when the friendly bacteria in your gut (probiotic bacteria) digest and break down fibers (prebiotics).
Although postbiotics are technically considered waste products, they offer various health benefits, similar to probiotics.
Benefits of postbiotics include reducing inflammation, mimicking the effects of probiotics, killing pathogens, regulating hormone and insulin levels, and increasing immunity.
Postbiotics are generally safe and well-tolerated and can be purchased from some health food stores and online. Alternatively, you can naturally increase your body’s production of postbiotics by consuming more prebiotics and probiotics.