Magnesium Glycinate 180 tablets - magnesium bisglycinate supports healthy muscle, nerve and hart function | NOW

NOW Magnesium glycinate 180 tablets

Magnesium glycinate utilizes magnesium bound to the amino acid glycine, which facilitates intestinal absorption. Magnesium is a mineral that is critical for energy production and metabolism, muscle contraction, nerve impulse transmission, and bone mineralization. It is a required cofactor for an estimated 300 enzymes. Among the processes that require magnesium are fat and protein production, as well as glucose metabolism. Magnesium status is also important for regulation of calcium balance through its effects on the parathyroid gland.

benefits
• nervous system
• sleep
• cardiovascular system
• muscle relaxation
• bone synthesis
• mental relaxation
• aminochelated with glycine 
• produced with a patented Albion process
• better absorbed and tolerated than many other magnesium supplements 

background reading

Magnesium is a co-factor in more than 300 biochemical reactions in the body. It is necessary for the transmission of nerve impulses, muscle function, temperature regulation, allowing food to be converted to energy, detoxification reactions, providing cardiovascular benefits and for the formation of healthy bones and teeth.
Magnesium is one of the most abundant minerals in the human body and is considered critical.
Glycine is an amino acid and acts like an inhibitory neurotransmitter in the brain, creating calmness. For stability purposes, supplemental magnesium must be bound to another molecule, and each 'form' of magnesium varies in bioavailability, therapeutic benefits and undesired effects depending upon which molecule it is bound to.

Magnesium (bis-)glycinate is considered a "chelated" mineral. Chelation refers to a process whereby the mineral (magnesium) is bound to an amino acid (glycine) to create a "complex" that provides the highest level of bioavailability and is ideal for those trying to correct deficiency.

who benefits from using Magnesium Glycinate?
Unlike many other forms of magnesium, Magnesium (bis-)Glycinate is well tolerated and does not cause diarrhea, especially in sensitive individuals.
Deficiencies are highly common, despite the abundance of magnesium available in green leafy vegetables, grains, legumes, nuts and seeds.
This may be due to the prevalence of processed food consumption, as refining food depletes its magnesium content by up to 85%. Chronic fatigue, weakness, irritability, muscle stiffness and mood imbalances are signs indicative of deficiency.
Other factors which contribute to magnesium deficiency include: certain medications, Crohn's disease, WIBS and celiac disease. Type 2 diabetics may have increased urinary magnesium excretion. Older adults may also be at increased risk for deficiency due to age-related changes in gastrointestinal physiology.
Magnesium absorption is also impaired by excessive alcohol, salt and and coffee chronic consumption diarrhea, profuse sweating, prolonged or intense stress and chronic diarrhea.

how does Magnesium Glycinate work?
Approximately 99% of total body magnesium is located in the bones, muscles and non-muscular tissue where a majority of its role is for storage and bone strength. The remainder is found as intra and extracellular magnesium, where it performs a variety of biochemical roles. Its multitude of physiological functions can be attributed to two important properties:
1. Magnesium has the ability to form bonds with certain negatively charged ions, such as ATP, to 'activate' key enzymes involved in metabolism, energy production, DNA/RNA and protein synthesis
2. Magnesium balances the role of calcium entering cells, which regulates nerve signal transmission, muscle contraction, and prevents'excitotoxicity', which is the process that causes nerve cells to be damaged due to excessive stimulation. This has implications for managing blood pressure, heart rhythm and adequate neurological and cognitive functioning.

what does the research indicate?
Magnesium has been extensively studied, and the literature demonstrates a link between magnesium deficiency and many degenerative diseases. A majority of research indicates that magnesium reduces heart disease risk, high blood pressure, risk of diabetes and stroke, increases energy production, exercise tolerance, bone mineral density and can manage pain and migraines. The following section focuses on why magnesium is crucial.

Bone health
Magnesium is required for bone mineralization and bone metabolism.It influences the activities of key bone cells, osteoblasts (bone building cells) and osteoclasts (bone destroying cells). Magnesium also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Numerous studies have found positive associations between magnesium intake and bone mineral density in both men and women.

Cardiovascular health
Studies indicate that high magnesium intake is associated with a low prevalence of cardiovascular events due to its role in managing blood sugar and blood pressure. Magnesium relaxes and maintains the normal structure of blood vessels and balances electrolytes which are necessary in the maintenance of normal blood pressure.
In the six year Atherosclerosis Risk inCommunities (ARIC) study of 7,731 individuals, the risk of developing high blood pressure was reduced as blood magnesium levels increased.
It is believed that pancreatic beta cells, the cells responsible for insulin secretion become less responsive in magnesium deficient individuals.
In a randomized,double-blind, placebo controlled, human study, a daily consumption of 638 mg of magnesium for three months, improved beta cell function and resulted in lower blood glucose and insulin levels.
Magnesium is also considered a "natural calcium channel blocker";it helps regulate the amount of calcium in the blood and cells, to prevent hyper-excitability and assists in keeping the blood vessels clear.

Mental health
Magnesium is involved in regulating the excitability of the central nervous system, relaxing muscles and regulating neuronal nitric oxideproduction.It has been hypothesized that magnesium deficiency is a cause of many major mental health disorders. In a state of deficiency, the brain can become hyperactive and lead to alterations in mood and cause irritability and agressive beahviour. Magnesium is considered to be one of the most critical minerals for mood regulation.

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