Ortho Eyes 2x5ml drops - N-acetyl-L-carnosine | AOR

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AOR Ortho Eyes is a topical N-acetyl-L-carnosine supplement for the eyes. N-acetyl-L-carnosine is a unique form of the dipeptide carnosine, which allows for its delivery to tissues within the eye not accessible to free carnosine topical supplements.
Research supports the ability of topical carnosine and N-acetyl-L-carnosine supplements to support eye structure and function, especially for cataracts.

Carnosine's Eye Benefits
Carnosine is a compound that helps to clear out damaged proteins. This feat is particularly important for vision since damaged proteins are involved in almost all aspects of age-related vision decline. Studies have shown that topical carnosine alleviates eye tiredness, improves eyesight, and clears vision. In people who had undergone laser eye surgery, carnosine reduced corneal haze and sped up tissue healing.

A Better Delivery System
Carnosine itself is destroyed by the enzyme carnosinase, and is therefore less effective than N-acetyl carnosine, which is why Ortho Eyes contains the latter form. Furthermore, N-acetyl carnosine is able to access areas of the eyes that free carnosine cannot get to. Once inside, N-acetyl-carnosine is slowly converted back into free carnosine.

Improves Vision in All Kinds of Eye Conditions
N-acetyl-carnosine eyedrops have been found to improve lens transparency and visual acuity in people suffering from senile cataracts. They also reduce glare disability in elderly drivers, improving vision in people with and without cataracts. Ortho Eyes helps to optimize vision, both in those whose eyes are deteriorating and in those who want to keep their healthy eyes working well.

background reading
A Revolution in Orthomolecular Eye Health!
The excitement surrounding the dipeptide Carnosine began when researchers at the Commonwealth Scientific and Industrial Research Organization (CSIRO), Australia's premier scientific research center painstakingly documented the unthinkable: that carnosine can not only slow down, but actually reverse, cellular senescence - the process of "aging" at the cellular level.

Based on their results, scientists "propose that carnosine is an important component of cellular maintenance mechanisms," and "favor the view that it may have a very important role in controlling cellular homeostasis" - that is, in keeping cells in the tightly-regulated condition that optimizes their function.

Taking Out the Trash
But how Carnosine exerts these effects remains a mystery. In test-tube studies, Carnosine protects cells and biomolecules against a sweeping range of toxic insults. The one protective effect that's probably received the most attention in the life extension community is its ability to protect proteins against glycation - the process through which sugars bind to proteins and warp their structure, turning functional proteins into dysfunctional Advanced Glycation Endproducts (AGEs). But this effect has only been shown to happen in test tubes: it's not really clear that the same thing would happen in a living person, and in fact there's good reason to believe that it won't.

Instead, it appears that Carnosine may attack the same problem from a different angle, actually boosting the cell's ability to clear out damaged proteins once they're formed. One of the problems with damaged proteins is that their mangled structures often don't give easy access to the enzymes that normally digest worn-out cellular components, making it difficult for the cell to remove them. Experimental studies have found that Carnosine reacts with proteins which have already been damaged by glycation and other assaults on their structural/functional integrity, forming "carnosylated" complexes which appear to be more easily removed than the original, warped protein.

At the same time, other such studies suggest that Carnosine revs up the proteasome - the cell's "recycling center" for malformed proteins. Instead of blocking the formation of AGEs, in other words, Carnosine might actually help the body to eliminate glycated and other dysfunctional proteins.

The results at the cellular level are enticing. The question that begs to be answered next is: how do these effects translate out on a larger scale - on the health of our tissues and organs - when you supplement with Carnosine?

Eyes Syruped Shut
Misshapen proteins accumulate across the entire structure of the eye with "normal" aging, interfering with visual functioning. AGEs, in particular, play a major role in the universal age-related loss of eye structure and function, as well as in the more specific degenerative diseases of the aging eye, such as cataracts, glaucoma, and age-related macular degeneration (AMD).

Delivering Carnosine directly to the eye itself, then, would be predicted to be the ideal real-world test case for the test-tube finding that Carnosine can protect against - and perhaps even actually undo - the damage wrought by glycation and other protein-warping mechanisms of aging. New human trials have shown that topical Carnosine delivers on this promise.

• In an open study protocol, scientists gave Carnosine supplements to patients in late middle age who had varying degrees of visual impairment, but no symptomatic cataracts. Over the course of two to six months, the scientists observed that the use of topical Carnosine supplementation "appears to alleviate eye tiredness and ... obviously improve eyesight, giving more clear vision." Users found that topical Carnosine "could brighten and relax their eyes." The improvements were statistically significant.

The results of the many human trials constitute proof-of-concept for the wider concept that the use of topical Carnosine - and especially the unique Carnosine metabolite N-Acetyl-L-Carnosine, a biological "delivery system" for Carnosine - can help the eyes to heal from damage, and allow the body to remove dysfunctional proteins from the eye. When you put that together with the fact that malformed proteins are implicated in nearly every aspect of age-related visual decline, these studies clearly point to the potential of Carnosine/N-Acetyl-L-Carnosine eye drops to support the maintenance of normal, healthy eye structure and function in people whose eyes are just fine - and whose owners want to keep them that way.

An Important Note About Formulation
In all of the clinical trials, N-Acetyl-L-Carnosine has been used by itself, with no added antioxidants or other ingredients other than other than formulants (such as buffering agents) required to make a viable N-Acetyl-L-Carnosine ophthalmic solution. The metabolism of N-Acetyl-L-Carnosine into Carnosine depends on enzymes in the body (N-acetylesterase and N-acetyltransferase), which accomplish this transformation as part of their normal biological function. The activity of these enzymes can be significantly changed by the presence of antioxidants other than N-Acetyl-L-Carnosine in the area.

Therefore, mixing N-Acetyl-L-Carnosine with other antioxidants - such as vitamin A or alpha-tocopherol - in the same formula is asking for trouble. Under these circumstances, the conversion of N-Acetyl-L-Carnosine into Carnosine will be altered, with unpredictable results on the levels of free Carnosine delivered to different tissues within the eye.

The results observed in clinical trials flow from the natural, unmodified kinetics of these enzymes. Products which adulterate N-Acetyl-L-Carnosine with unnecessary additional antioxidants are untested, potentially ineffective, and may theoretically even damage your vision in the long term by leading to the inappropriate tissue-specific release of Carnosine, conversion to histamine, and resultant chronic, low-level inflammation. Ensure that any N-Acetyl-L-Carnosine supplement you use is free of extraneous antioxidants. 

uses for AOR Ortho Eyes
• Helps clear out damaged proteins in the eyes
• Increases lens clarity
• Reduces the risk of age-related eye disorders
• Reduces glare sensitivity

code GTIN
code MPN
Advanced Orthomolecular Research
best before
Oct 2024
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  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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recommended use
Put 1 drop in each eye 1-4 times a day or as directed by a physician.
When used twice a day, each vial will last for 10-14 days.

how to apply
Open the vial by twisting off the plastic cap and removing the collar carefully without letting it touch the tip. 
By screwing the cap back onto the vial, the tip of the vial will be punctured by the sharp tip inside the tip. 
After screwing off the cap again, Ortho Eyes is ready to be used.
Thereafter proceed as followed:
- lean head back and look up (if you have neck problems, lie down or use a tilt-back chair)
- pull your eyelids gently open with clean fingers
- bring the nozzle of the bottle closer to your eye
- use a mirror to help you if needed
- press slightly on the bottle to release one drop at a time
- do not blink or reopen the eye for 60 seconds (closing the eye allows each drop to be absorbed into the eye tissue, while blinking, even one or two times, will pump most of the solution out of the eye)
- repeat this procedure if a second drop is used

Do not touch the tip of container to your eye, your eyelid, or any surface. Replace the cap immediately after using. Open only one container of solution at a time.
Do not allow other people to use your container. Do not use if seal is broken or if solution changes color or becomes cloudy. Once open, discard container and any contents after 30 days.

contains per daily serving (1 drop)
N-acetyl-L-carnosine 1% solution 0.3mcg

filler (sterile water (ophthalmic grade solution pH 6.3-6.5), active ingredient (N-acetyl-L-carnosine), lubricant (glycerine, sodium hydroxypropylmethylcellulose), buffer (borate, potassium bicarbonate), preservative (purified benzylalcohol)

This product can be stored at normal room temperature between 15 - 22°C, however to obtain maximum shelf life, this product should be stored in the refrigerator, but do not freeze.
Do NOT allow the content to go over room temperature.
keep out of reach of young children

none indicated
If the eye tissue becomes more inflamed, red, irritated or uncomfortable after using this product, immediately discontinue the use of product and consult an eye-physician if necessary

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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