TMG trimethylglycine 1000mg 100 tablets - betaine supports a healthy homocystein level | NOW
NOW TMG trimethylglycine tablets contains trimethylglycine (TMG, also known as anhydrous betaine), a highly effective methyl donor extracted from sugar beets.
- supports healthy homocysteine levels
- promotes normal methylation processes
Methyl donors, such as TMG and folic acid, are required for converting homocysteine back into methionine and for the accurate synthesis of DNA and RNA, which is essential for the production of normal cells.
Methylation is inhibited by inadequately functioning key enzymes, excessive protein and fat intake, poor diet, inadequate intake of methyl groups, coffee, alcohol or by smoking. Impairment of methylation results in abnormal cell synthesis and elevated levels of homocysteine, a toxic amino acid and a serious health risk.
For athletes, TMG is interesting because it can increase the work capacity of fast twitch muscle fibers, resulting in an increased endurance capacity and a raised lactate threshold. TMG is also interesting for strength athletes who use creatine or citrulline supplements , because a methyl-group is needed for complete conversion.
What is homocysteine and why does it matter?
Homocysteine is sometimes called the “new cholesterol” because of its role in cardiovascular health. High blood levels of this compound are damaging in themselves but elevated readings may also be indicative of sluggish homocysteine metabolism. In addition, homocysteine levels are raised by such factors as poor diet, smoking, genetic predisposition and low levels of B vitamins (folic acid, B6, and B12).
The essential amino acid methionine, which comes only from the diet, is “used up” by the body to help donate a methyl group (CH3 - one carbon linked to three hydrogen atoms) to processes going on in every cell. These processes lead to the conversion of some of this methionine to homocysteine, and then into homocysteine thiolactone. This latter compound is a highly toxic metabolite or byproduct. The remethylation of homocysteine, with the help of folic acid, vitamin B12 and trimethylglycine (TMG), converts homocysteine back into methionine.
The methionine-homocysteine axis must be kept working smoothly and efficiently to reduce the levels of toxic homocysteine. A certain amount of homocysteine is present in the blood and tissues at any given time, but high levels are undesirable. It is also important to keep levels of S-adenosyl-methionine (SAM-e) high in modulating the methionine-homocysteine axis. Homocysteine poses a threat only when the pathways to its conversion inside the cells are sluggish. When this happens, homocysteine is exported into the blood, where it causes damage.
For optimal health, both the pathway from homocysteine to methionine and SAM-e and the pathway from homocysteine to the amino acid cysteine (and, ultimately, elimination) must be operating smoothly. A build-up in serum homocysteine indicates that either one or both of the transformation pathways are sluggish. Vitamin B6 is the most important nutritional factor for keeping the second “elimination” pathway working smoothly
Link between methyl donors and anti-oxidants
Methylation helps remediate certain toxic compounds in ways typical antioxidants do not. Homocysteine is one of these compounds.
Methyl donors also act to support the transformation of compounds within the cells, such as the production of neurotransmitters and the anti-infl ammatory polyamines, and to protect DNA from damage. In this sense, the protective roles of methyl donors and antioxidants are complementary.
Methyl donors can improve the antioxidant status of the body indirectly by taking on some of the protective duties performed by antioxidants. However, methyl donors also add directly to the body’s antioxidant capacities by increasing the production of the antioxidant glutathione. With the help of vitamin B6, degradation of homocysteine provides precursor sulfur for the biosynthesis of taurine.
Aging and homocysteine levels and reduced methylation
Most of the conditions which are thought to be linked to sluggish homocysteine metabolism are, likewise, linked to the aging process.
The methylation pathway declines with age, and this decline leads to a loss of the detoxifi cation and repair operations which must be continuously renewed to maintain good health. For instance, methylation is perhaps the body’s most important built-in mechanism for protecting cellular DNA. Supplementation with methyl donors thus becomes one of the options which should be considered for maintaining sound health under conditions of stress and advancing years
Methylation for the liver and the brain
Methyl donors play a large role in the liver’s functions, in part because of their ability to support glutathione production for antioxidant protection and bile production for the disposal of toxins. Methyl donors, moreover, are amongst the classic lipotropics, substances which improve the ability of the liver to process fats and alcohol.
The brain is another organ which depends greatly upon methylation. Transmethylation is so pervasive in the formation, release and reuptake of neurotransmitters that it is difficult to pinpoint any one brain mechanism paramount in importance. However, the regulatory mechanisms of the neurotransmitters epinephrine, norepinephrine, serotonin and dopamine all depend on methylation.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
take 1 tablet per day with a meal
take 2 to 3 tablets 30 minutes prior to a training or competition
contains per daily serving (3 tablets)
trimethylglycine (anhydrous betaïne) 3000 mg†
† = Recommended Daily Intake not established
active ingredient (trimethylglycine (betain)), filler (microcrystalline cellulose, hydroxypropylcellulose), vegetarian coating, filler (vegetarian stearic acid, sodium croscarmellose, vegetable magnesium stearate)
store in a cool, dry place
keep out of reach of young children
keep the bottle tightly closed at all times in between usage with the freshness packet inside bottle as TMG is very sensitive to moisture/humidity which may affect product stability.
For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans