SAM-e 400mg 60 tablets - S-Adenosyl Methionine | Jarrow Formulas
Jarrow Formulas SAM-e 400mg 60 tablets :SAM-e is an amino acid derivative clinically proven to benefit brain, liver and joint function. Found in all living cells, SAM-e is called “activated methionine”, formed by the combination of ATP and methionine. Methionine supplementation, however, does not elevate SAM-e. Rather, it elevates toxic homocysteine.
SAM-e has undergone many clinical trials involving thousands of patients. Researchers have identified many structure and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, enhancing cartilage formation and lifting mood.
SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function. GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.
SAM-e supports brain function by its methylation effects. Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donators in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism.
Neurotransmitters, substances involved in nerve cell communication, are products of methylation. These compounds include L-dopa, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). There is a connection between SAM-e levels and cognitive health. Conversely, increasing serotonin and dopamine levels contribute to brain health and improved mood. SAM-e works quickly; many people feel the effects within a week.
Methylation from SAM-e is critical for creatine production. Creatine metabolites are important for ADP to ATP recycling, and storing energy for immediate needs. Creatine maximizes physical performance, reduces exercise fatigue and improves recovery after exercise.
A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often mitigated by SAMe supplemention.
Methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.
Healthy connective tissue
Research has shown that regular SAM-e supplementation helps improve joint health, and is used in Europe by physicians for the management of knee pain.
Not all SAM-e is created equal
SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, and results in maximum blood levels.
main characteristics of SAM-e
• supports the lubrication of the joints
• supports the brain function
• supports proper methylation which in turn slows the aging proces of the body
• supports the synthesis of glutathione (GSH) and glutathion dependent enzymes
• essential for detoxification enzymes in the liver
• the most important methyl-donating substance
• supports the production of healthy connective tissue
• blister packed for ultimate protection
- resists stomach acid
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Skin hunger: why we crave touch
As we are in the midst of the Easter Holiday, we can't help but feel sad. While Mother Nature is showing abundant signs of spring during a period of incredibly sunny weather, we are barely allowed to go outside other than to do what is absolutely necessary. Our gyms have been closed for almost a month now while in some countries, people aren't even allowed to exercise. Not just group exercise, but also to just jump on a bike and go for long rides.
While couples and families get grumpy from living together in a cramped space, others face different problems: they are living without any companion whatsoever. Therefore it's not a miracle how all of a sudden, pet asylums have been able to 'clear out' their list of unwanted pets. Not just because people have more time at hand to walk a dog (just about the only thing some are allowed to do) but also because they crave the ability to touch a living being, for lack of being able to touch another human.
Somehow, just like the sense of smell is overlooked, this also is true for the sense of touch. Only when we lose it, we crave it. This craving also is called 'touch hunger' or 'skin hunger'.
PFAS pollutants causing turmoil
In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.
Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.
If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.
Why is glutathione so important for your health?
Glutathione is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, glutathione is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine.
There are a number of reasons why your body’s glutathione level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age.
Maintaining adequate levels of this antioxidant is incredibly important. Below are some of the best ways to increase your glutathione levels naturally.
How to beat andropause, the condition that ails all elderly malesAndropause is a medical condition, similar to the female menopause, that can affect men between the ages of 40 and 65. Men do not have a clear-cut signpost to mark the transition. In women estrogen drops dramatically at menopause, but testosterone levels in men drop very gradually over many years and decades. The bodily changes in andropause occur very gradually in men and may be accompanied by changes in attitudes and moods, fatigue, a loss of energy, sex drive, stamina, and physical agility.
Andropause may be triggered not only by declines in testosterone, but in the "female" hormone estrogen as well.
There is a growing interest, as well as a booming industry, in the use of testosterone therapy for middle-aged and older men. This interest has led to the definition of a new condition, termed 'andropause' implying that this condition is due to falling levels of testosterone. This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence. Is testosterone therapy appropriate for men with symptoms of male menopause? There is no scientific agreement on this topic.
But it stands to reason that hormones should be used only as a last resort since they have serious risks if misused.
take 1 tablet a day, with water (NOT milk) preferably on an empty stomach preceding a meal or as advised by a qualified physician
For optimal use as a joint supplement, combine SAM-e with JarroSil (biologically active silicon)
For optimal use as prevention of hangovers, take before imbibing alcohol
contains per daily serving (1 tablet)
S-Adenosyl Methionine 400mg
(from 800mg of SAM-e tosylate disulfate)
active ingredients (SAM-e tosylate disulfate), fillers (cellulose, glyceryl behenate, vegetable magnesium stearate), anticoagulant (silicon dioxide), sweeetener (mannitol), filler (sodium starch glycolate), enteric coating (modified cellulose, magnesium silicate, triethyl citrate and riboflavin)
store in a cool, dry place.
keep out of the reach of children
Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.
this product contains no wheat, no gluten, no soy, no dairy, no egg, no fish/shellfish, no nuts/tree nuts.
suitable for vegetarians and vegans