SAM-e 200mg 60 tablets S-adenosylmethionine | Jarrow Formulas
Jarrow Formulas SAM-e 200 60 tabs :SAM-e is an amino acid derivative clinically proven to benefit brain, liver and joint function. Found in all living cells, SAM-e is called “activated methionine”, formed by the combination of ATP and methionine. Methionine supplementation, however, does not elevate SAM-e. Rather, it elevates toxic homocysteine.
SAM-e has undergone many clinical trials involving thousands of patients. Researchers have identified many structure and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, enhancing cartilage formation and lifting mood.
SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function. GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.
SAM-e supports brain function by its methylation effects. Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donators in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism.
Neurotransmitters, substances involved in nerve cell communication, are products of methylation. These compounds include L-dopa, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). There is a connection between SAM-e levels and cognitive health. Conversely, increasing serotonin and dopamine levels contribute to brain health and improved mood. SAM-e works quickly; many people feel the effects within a week.
Methylation from SAM-e is critical for creatine production. Creatine metabolites are important for ADP to ATP recycling, and storing energy for immediate needs. Creatine maximizes physical performance, reduces exercise fatigue and improves recovery after exercise.
A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often mitigated by SAMe supplemention.
Methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.
Healthy connective tissue
Research has shown that regular SAM-e supplementation helps improve joint health, and is used in Europe by physicians for the management of knee pain.
Not all SAM-e is created equal
SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, and results in maximum blood levels.
main characteristics of SAM-e
• supports the lubrication of the joints
• supports the brain function
• supports proper methylation which in turn slows the aging proces of the body
• supports the synthesis of glutathione (GSH) and glutathion dependent enzymes
• essential for detoxification enzymes in the liver
• the most important methyl-donating substance
• supports the production of healthy connective tissue
• blister packed for ultimate protection
- resists stomach acid
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Common foods that are dangerous for our petsLast week we sold SAM-e to a dog owner who had been told by her vet to give it to her dog that accidentally was poisoned eating xylitol.
Xylitol, I asked in disbelief? That sweetener that is recommended by each dentist to use as a chewing gum because it is even healthy for us?
Yes, indeed, xylitol can and will poison your pet as it can't process it and as a result will cause damage to the liver.
After having induced vomiting, and being put on intubation to keep fluids up, the dog could go back home with his owner with the advice to give it one tablet of SAM-e every day in order to heal the liver.
Most of you probably also didn't know either how xylitol can be poisonous for pets. Which begs the question: what foods that we love to eat are poisonous for cats and dogs and should never be fed to them?
If your pet eats any of these things then the best thing to do is to get advice straight away from your local vet. Don't wait until they are developing problems because by then it could be too late. It will certainly be much more expensive. Don't leave them lying around and make sure they are stored away safely in cupboards. Preferably ones your pet can't open!
Here's a list of the most common poisonous foods that can kill your dog or cat.
Skin hunger: why we crave touch
As we are in the midst of the Easter Holiday, we can't help but feel sad. While Mother Nature is showing abundant signs of spring during a period of incredibly sunny weather, we are barely allowed to go outside other than to do what is absolutely necessary. Our gyms have been closed for almost a month now while in some countries, people aren't even allowed to exercise. Not just group exercise, but also to just jump on a bike and go for long rides.
While couples and families get grumpy from living together in a cramped space, others face different problems: they are living without any companion whatsoever. Therefore it's not a miracle how all of a sudden, pet asylums have been able to 'clear out' their list of unwanted pets. Not just because people have more time at hand to walk a dog (just about the only thing some are allowed to do) but also because they crave the ability to touch a living being, for lack of being able to touch another human.
Somehow, just like the sense of smell is overlooked, this also is true for the sense of touch. Only when we lose it, we crave it. This craving also is called 'touch hunger' or 'skin hunger'.
PFAS pollutants causing turmoil
In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.
Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.
If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.
Why is glutathione so important for your health?
Glutathione is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, glutathione is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine.
There are a number of reasons why your body’s glutathione level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age.
Maintaining adequate levels of this antioxidant is incredibly important. Below are some of the best ways to increase your glutathione levels naturally.
How to beat andropause, the condition that ails all elderly malesAndropause is a medical condition, similar to the female menopause, that can affect men between the ages of 40 and 65. Men do not have a clear-cut signpost to mark the transition. In women estrogen drops dramatically at menopause, but testosterone levels in men drop very gradually over many years and decades. The bodily changes in andropause occur very gradually in men and may be accompanied by changes in attitudes and moods, fatigue, a loss of energy, sex drive, stamina, and physical agility.
Andropause may be triggered not only by declines in testosterone, but in the "female" hormone estrogen as well.
There is a growing interest, as well as a booming industry, in the use of testosterone therapy for middle-aged and older men. This interest has led to the definition of a new condition, termed 'andropause' implying that this condition is due to falling levels of testosterone. This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence. Is testosterone therapy appropriate for men with symptoms of male menopause? There is no scientific agreement on this topic.
But it stands to reason that hormones should be used only as a last resort since they have serious risks if misused.
The power of positive thinking
Why is stress so hard on the body?When we are stressed, our bodies produce higher levels of cortisol, a hormone that shuts down the thinking center of our brains and activates conflict aversion and protection behaviors. We become more reactive and sensitive. We often perceive even greater judgment and negativity than actually exists. And these effects can last for 26 hours or more, imprinting the interaction on our memories and magnifying the impact it has on our future behavior. Cortisol can be self-inforcing, the more we think about a stressful event, the bigger and longer the impact.
Positive comments produce a chemical reaction too. They spur the production of oxytocin, a feel-good hormone that elevates our ability to communicate, collaborate and trust others by activating networks in our prefrontal cortex. But oxytocin metabolizes more quickly than cortisol, so its effects are less dramatic and long-lasting.
In order to counterbalance the effect of stress, a much higher amount of positive events must happen, which in the real world, is not so easy to achieve.
Another factor which makes it harder to achieve happiness, is that every individual has a 'happiness set point'.
A happiness set point is the point on a continuum of happiness with which we are born.
In early research it was concluded that positive events (such as winning the lottery) and negative events (such as an accident) change our happiness levels for a short period of time, until after a while, we return to the baseline, our happiness set point.
Lately though it has been shown that we *can* change our setpoint. This however, is not very easy and requires hard work!
So let's look at the factors that can help influence happiness!
When is drinking alcohol bad for your health?In the past decade we were told indulging in one or two glasses of alcohol (just one for women) a day is healthy. This was even one of the many recommendations in the national (Dutch) health guidelines. In the past year though, a drastic change occurred: the recommendation changed into zero to perhaps to a most one glass of alcohol a day! So, what gives?
OCD?! Obsessive behaviourWhomever is actively dieting and counting calories for a prolonged period of time, may have been teased by friends of having OCD. Is counting calories obsessive behaviour?
For an obese person, it is is easier to simply cut calories by cutting entire food groups such as wheat, foregoing desserts, eat from smaller plates or fast intermittently.
For someone at a normal weight trying to get very lean it makes perfect sense to count calories as this requires far more precision.
general health: take 1-2 tablets a day, with water (NOT milk) preferably on an empty stomach preceding a meal or as advised by a qualified physician
For optimal use as a joint supplement, combine SAM-e with JarroSil™ (biologically active silicon)
For optimal use as prevention of hangovers, take before imbibing alcohol
pet (cat/dog): give 1 tablet on an empty stomach. When your pet refuses to ingest the tablet, you may hide it in a snack. Make sure that your pet drinks some water after giving SAM-e to ensure that the supplement is completely swallowed.
Recommended dosage is 20mg/kg bodyweight. Since the tablets cannot be split, the size of tablet closest to the calculated dose should be administered. For short-term use e.g. after poisoningm a higher dosage is not a problem.
contains per daily serving (1 tablet)
S-adenosyl Methionine 200mg†
(from 400mg SAM-e tosylate disulfate)
† = Recommended Daily Intake not established
active ingredients (SAM-e tosylate disulfate), fillers (cellulose), sweetener (mannitol), preservative (glycerol behenate), filler (vegetable magnesium stearate), anticoagulant (silicon dioxide), filler (sodium starch glycolate), enteric coating (modified cellulose, magnesium silicate, triethyl citrate and riboflavin)
store in a cool, dry place
do not take if pregnant or lactating unless under guidance of a qualified physician
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans