Jarrow Formulas Quercetin 500mg 200 capsules is a flavonol (a subclass of flavonoids) and is a potent antioxidant, providing cardiovascular protection by reducing oxidation of LDL cholesterol. Quercetin is one half of the rutin molecule, another flavonol, and is the more active antioxidant.
Flavonoids, including quercetin, occur naturally in fruits, vegetables, nuts, seeds, flowers and bark. Scientific evidence has shown quercetin to scavenge free radicals as well as to inhibit oxidation and cytotoxicity of LDL cholesterol.
Quercetin is a plant flavonoid with histamine modulating properties. A great deal of evidence supports the modulatory action of flavonoids like quercetin on mast cells and associated immune factors. Many believe quercetin to be the most effective of these flavonoids in preventing and improving an over-reacting immune system caused by seasonal stimuli like hayfever. In one Japanese study of mast cells from the nasal lining of individuals who were experiencing seasonal challenges, quercetin significantly attenuated histamine release.
Quercetin is a plant-source flavonol often found attached to sugars in fruits, vegetables, and other botanicals such as onions, shallots, apples, berries, grapes, capers and tea. In plants, quercetin influences the behavior of auxins, or growth regulators, allowing plants to adapt to their environment. Quercetin compounds may also aid in the protection of the plant from UV radiation and contribute to flower pigmentation via fluorescence-induced tautomerism.
Quercetin, in its many forms, has been attributed a number of health effects in humans. As such, quercetin levels in produce have been used as a relevant metric to demonstrate differences between organically and conventionally grown fruits and vegetables. For example, one study found that organically grown tomatoes averaged 80% higher levels of quercetin than other tomatoes. Such evidence lends support to the idea that fruits and vegetables can vary well beyond what the eye can see.
Quercetin and Human Health
Discussion about quercetin and health must start with oxidative protection, since that is the rationale often touted for taking quercetin. In vitro studies indicate that quercetin clearly possesses antioxidant activity and helps protect LDL from oxidation. Yet, in vivo studies have often had mixed results demonstrating antioxidative effects in the body—variation that is likely related to the bioavailability of quercetin in its various forms.
As with most substances that are termed “antioxidants,” one must look at more specific activity to understand the true health benefits of quercetin, as it is often the combined effect of various specific actions that lead to overall benefit. Quercetin, for instance, has been shown to modulate tyrosine kinase, the synthesis of nitric oxide, and the actions of NF-kappa-beta, concerted activity that assuredly has wide-ranging effects on the body that are not yet completely understood.
Nevertheless, epidemiological evidence has long supported an association between an increased dietary intake of flavonoids and cardiovascular protection. Recently, a supplementation trial with quercetin has done so. For quercetin, many researchers contend that the link involves not only protection against peroxidation of blood lipids but also regulation of monocyte attachment to vascular endothelial cells. Together, such mechanisms could undergird findings that quercetin promotes healthy blood pressure and other cardiovascular effects. Interestingly, at least one study has found that quercetin benefits can depend upon genetic variation of apolipoprotein E alleles.
In relation to blood sugar, quercetin modulates the action of aldose reductase. This enzyme is involved in the conversion of blood sugar (glucose) to sorbitol and is excessively active when blood sugar concentrations are high. The accumulation of sorbitol in the nerves of peripheral tissues is associated with poor nerve function. Similarly, sorbitol can accumulate in the lens of the eye. In lens tissue, sorbitol is not metabolized because the degradation enzyme (polyol dehydrogenase) is non-existent. And since lens tissues aren’t serviced by blood-flow, it is very difficult for the lens to rid itself of sorbitol once it accumulates. As a result, sorbitol build-up can lead to poor eye health.
As mentioned above, the benefits of quercetin in humans may hinge upon its bioavailability. Past data has suggested that quercetin attached to a sugar molecule, especially glucose in the 4-position as is prevalent in onions, supports uptake in the digestive tract. It’s been conjectured that this may be because of increased water-solubility or possibly specific, active transport mechanisms in the intestines. Other data indicates that ingested quercetin sugar-conjugates are first cleaved to form quercetin aglycone before absorption and that the aglycone may be more bioavailable than sugar-conjugates. From a passive diffusion standpoint, the second idea appears reasonable, since the aglycone is more lipophilic and should more readily pass into intestinal enterocytes. This is perhaps one reason why it has been found that quercetin in oil is more bioavailable than in water.
Jarrow Formulas’ Quercetin contains quercetin (aglycone) a flavonol that is an effective antioxidant, providing cardiovascular support by protecting LDL from oxidation. Quercetin is one half of the rutin molecule, another flavonol, and is the more active antioxidant.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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Forget about exercising to lose weight: you can't outrun a bad diet!
What's the relation between histamine and gluten intolerance?A short while ago, I was alerted to research that is being conducted on histamine intolerance. The reason it piqued my interest was the remark on how perceived gluten intolerance may in reality be a case of histamine intolerance. The researchers that were interviewed spoke about probiotics being developed to 'cure' histamine intolerance.
Therefore, without further ado, an explanation on what histamine intolerance really is.
What is histamine?Histamine is an extremely important bioactive chemical that is indispensable in the efficient functioning of many body systems. It is a neurotransmitter and is involved in the regulation of stomach acid, the permeability of blood vessels, muscle contraction, and brain function.
In humans, the highest histamine concentrations are found in the skin, lung, and stomach, with smaller amounts in the brain and heart.
Histamine is also essential in defending the body against invasion by potentially disease-causing agents such as bacteria, viruses and other foreign bodies.
Histamine is made and stored within white blood cells such as mast cells.
When the immune system is activated in response to foreign material entering the body, histamine is the first "defense chemical", or more correctly, inflammatory mediator released in the process called inflammation. Inflammation is the clinical evidence that the immune system is responding to a potential threat to the body. Histamine is always present when inflammation occurs, and excess histamine will result in symptoms that resemble inflammation.
In addition to its role in controlling vital body processes and defending against foreign invaders, histamine is a key mediator in the symptoms of an allergic reaction. Since allergy is essentially an inflammatory reaction, histamine, together with other protective inflammatory mediators is released in response to the allergen.
Allergens are components of living cells that in themselves are harmless, such as plant pollens, animal dander, mould spores, dust particles, dust mites, and foods. An allergic reaction to these "foreign but harmless" substances occurs when the immune system mistakes these innocuous materials for a potential threat.
Particulate matter and your healthAs the Dutch government decided to move away from natural fossilized energy sources, we are moving towards solar and wind energy.
Because solar and wind energy cannot provide all energy and a decision to also move away from natural gas, biomass plants seemed to be the perfect solution.
Biomass is plant or animal material used for energy production (electricity or heat). It can be purposely grown energy crops, wood or forest residues, waste from food crops (wheat straw), horticulture (yard waste), food processing (corn cobs), animal farming (manure, rich in nitrogen and phosphorus), or human waste from sewage plants.
Burning plant-derived biomass releases CO2, but it has still been classified as a renewable energy source in the EU and UN legal frameworks because photosynthesis cycles the CO2 back into new crops. In some cases, this recycling of CO2 from plants to atmosphere and back into plants can even be CO2 negative, as a relatively large portion of the CO2 is moved to the soil during each cycle.
However, over the past few months it has become clear how a lot of biomass comes from trees, that were previously pristine forests in the USA or the Baltics.
While in the best case, the use of biomass could even be CO2 negative, burning biomass will result in excessive CO2 output locally as well as of particulate matter.
This is why almost overnight, due to negative public opinion, politicians changed their mind. Too late though, there are already few hundred biomass plants that are being constructed due to substantial subsidies that were handed out, so we can expect a substantial worsening of air quality in the upcoming decade(s) because of the increased amount of particulate matter.
Zinc and HCQ
In the past few months, nearly everyone will have become familiar with the malaria drug hydroxychloroquine (HCQ) and how it has been welcomed as a miracle drug, only to be set aside as being too dangerous to expose sick patients with underlying cardiovascular diseases to it.
Upon learning how HCQ is supposed to be used in this crisis, I was flabbergasted to read how HCQ was put to use by itself, as a drug on its own. True enough, HCQ is a malaria drug, but it was not just meant to be used as a curative medicin on its own for COVID-19 but as a messenger to transport the true miracle mineral, zinc into cells.
The now famous Zelenko protocol which uses HCQ , azithromycin and zinc as well as a number of other essential vitamins and minerals, was never meant to be used in hospital either, but for use by doctors on patients who had just fallen ill.
Now the researchers who discredited HCQ in the Lancet article have been debunked as having used fraudulous data in order to promote a much more expensive drug in which one of the authors had a vested interested, we think it is about time to explain a thing or two on why and how HCQ is used in combination with zinc.
Health from a pineapple: combat inflammation with bromelainPineapples are one of the most well-loved tropical fruits around the world. But if you're a constant surfer of the web, you've probably come across an article or two saying that pineapples "eat you right back." And the culprit? It's none other than enzyme bromelain.
Aside from its popularity because of this viral information, bromelain has managed to penetrate the medical world because of the impressive health benefits it offers. If you're interested or curious on why bromelain is now getting unvaried attention, continue reading and know more about this pineapple product.
Why do we get the flu in winter?Being cold doesn’t literally make you catch a cold, but it certainly seems likely how the coldest season is, as a matter of fact, the 'cold' season. Why is there a substantial increase in common colds and flus as soon as it gets cold outside?
The flu really does thrive in winterThere’s no doubt that the flu virus somehow thrives in the cold.
As it turns out, the virus is basically designed to jump from person to person when the air is cold and dry. Studies have shown that transmission rates are highest when temperature and humidity are both low. Because cold air naturally holds less water, low humidity levels are typical for winter.
Even when we make our homes comfortably warm, the air stays just as dry unless we use a humidifier.
But why do viruses thrive in cold air?Cold air may help the flu virus survive longer outside of a human host, making it easier to linger after a cough or sneeze. And apparently the virus does a better job of circulating in low humidity.
An infected individual exhales virus encased in tiny water droplets, and those droplets evaporate more quickly if the air is dry. If the flu droplet shrinks fast enough, it can become so light that it circulates around in the air instead of falling to the ground.
How can allergies be avoided in children?Children who are exposed to more allergens and bacteria in their homes during the first year of life may be less likely to suffer from allergies, wheezing and asthma later on.
Researchers found that 3-year-olds who were exposed to mouse dander, cat dander and cockroach droppings before they turned 1 were three times less likely to suffer from wheezing, allergies and asthma than those who lived in homes without these allergens.
Breathe in, breathe out!Did you ever notice you don't have equal air flow through each nostril? Most people alternate between breathing through the left and the right nostril. The only time you are vividly aware of the existence of such a cycle is when you have congestion in just one side of the nose, which results in only being able to breathe more easily every few hours and then feel congested in the other period.
Take 1 or more capsules per day with meals, or as directed by your qualified health care consultant.
contains per daily serving (2 capsules)
quercetine 1000 mg †
† = Recommended Daily Intake not established
active ingredient (quercetine), filler (cellulose, magnesium stearate from vegetable source), anti-coagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)
store in a cool, dry place
keep out of reach of young children
Quercetine interacts with drugs and other food ingredients
Quercetine and antibiotics should not be combined since quercetine will reduce the effect of antibiotics
However quercetine enhances the absorption of curcumine, kaempferol and resveratrol, which makes them effective for therapeutic use at lower doses than is normally advised
Quercetine is safe, even in higher than normal everyday doses, except when quercetine is combined with medication like pain killers, hormonal preparations like BCPs , blood thinners, heart medication and anti-depressants
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans