QH-Absorb 100mg 120 softgels - ubiquinol (reduced co-enzyme Q10) | Jarrow Formulas
Jarrow Formulas QH-absorb 100mg 120softgels Ubiquinol is the reduced (active antioxidant) state of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age, genetics, blood sugar status or level of oxidative stress.
who can benefit from QH-absorb?
Designed for those who seek the superior absorption of ubiquinol for cardiovascular and antioxidant health. May be particularly useful to older consumers who may not activate CoQ10 sufficiently or whose levels have been depleted.
QH-absorb 100mg is in an enhanced stability formula that utilizes the Q-absorb natural proliposome lipid-soluble delivery system, which has been clinically shown in humans to increase Co-Q10 levels up to 400% (3.2x) over baseline and is 3-4 times better absorbed than chewable Co-Q10 tablets.
Ubiquinol is derived from Co-Q10 that is manufactured by means of a yeast-fermentation process and consists only of the natural trans configuration, the same as is biosynthesized in the human body. Jarrow Formulas supports clinical research on Coenzyme Q10.
• the most bioavailable and active form of Co-Q10
• high absorption natural proliposome delivery system
• No synthetic surfactants
• Pharmaceutical Grade Kaneka QH
Ubiquinones are a series of homologous molecules that possess a quinone active center and an unsaturated fatty tail. Ubiquinones are so named because they are widely distributed (i.e. ubiquitous) in nature and throughout the human body. Structurally they are very similar to the menaquinones, like vitamin K2. The quinone group is like a courier for protons and electrons, which is the critical property that allows ubiquinones to act as antioxidants and as important intermediates in energy generation. The fatty tail is composed of isoprenoid subunits, which are five carbon building blocks that help all living things biosynthesize critical components like immune modulators, essential oils and hormones. The number of isoprenoid units in the fatty tail is often denoted in the name of specific ubiquinones. For instance, ubiquinone-10 is made from ten isoprenoid units. Ubiquinone-10 (aka CoQ10, coenzyme Q10, Q) is more commonly referred to as just “ubiquinone.” This is because it is the most prevalent ubiquinone in almost all mammals, including humans.
Concern about CoQ10 levels is especially important in this day and age, because cholesterol lowering drugs (statins) work by inhibiting an enzyme that is also responsible for CoQ10-ubiquinol biosynthesis. As a result, anyone taking statins may have reduced levels of CoQ10-ubiquinol
What is ubiquinol
Ubiquinone and ubiquinol (aka ubiquinol-10, CoQ10-H2, QH, “reduced” CoQ10) are intimately related, as their names suggest. Inside the body, CoQ10 (ubiquinone) can only achieve its important functions in energy production, cardiovascular health and antioxidant protection with the help of ubiquinol. In fact, all of the benefits that have been attributed to CoQ10 necessitate ubiquinol involvement. The two do their work by shuttling electrons and protons back-and- forth, cyclically transforming from ubiquinone to ubiquinol and back again. In energy production, CoQ10 facilitates electron transfer within mitochondrial membranes to produce ATP, the body’s energy currency.
For antioxidant protection, ubiquinol is the “active antioxidant” form of CoQ10. This means that CoQ10 that has not been converted to ubiquinol is inactive as an antioxidant. Perhaps this explains why circa 80-95% of total CoQ10-ubiquinol exists as ubiquinol in the blood and in healthy tissues that require its antioxidant function.
Is taking ubiquinol better than taking coQ-10?
CoQ10 and ubiquinol are critically obtained from the diet, but it appears that absorption of CoQ10 may entail conversion to ubiquinol. This conversion occurs as early as in the enterocytes, the absorptive cells in the intestine, and may facilitate the absorption process. Also under normal conditions there are enzymes that help regenerate ubiquinol from spent CoQ10, in the body. Unfortunately, aging and illness can lead to both a reduced ability to regenerate ubiquinol because of decreased enzyme activity and a decreased ability to absorb CoQ10 itself, possibly for the same reason
After about age 45, total CoQ10 levels and ubiquinol levels in relation to CoQ10 tend to decline in various critical tissues. Some physicians have even started to use blood and tissue ratios of ubiquinol to CoQ10 as a biomarker for age- and illness-related oxidative stress. So it may not come as a surprise that taking ubiquinol can provide benefi ts that surpass those obtained from taking standard CoQ10. But where’s the evidence?
QH-absorb clinical research
Eleven young, healthy adults ingested 100 mg of QH-absorb with food three times daily (100 mg, t.i.d.) for fourteen days. Blood levels of total CoQ10, oxidized CoQ10 and reduced CoQ10 (ubiquinol) were measured at baseline and after fourteen days. This regimen of QH-absorb consumption resulted in a 777% mean increase of total CoQ10 levels compared to baseline and a 100% increase in plasma ubiquinol levels, the “active antioxidant” form of CoQ10.
Two conclusions can be drawn from these study results. First, it appears that even young, healthy individuals can achieve benefits from taking ubiquinol from QH-absorb that surpass taking CoQ10 alone. Previously, it was presumed that only older individuals would benefit from taking QH-absorb as it is known that starting about the age of 40, ubiquinol levels begin to decrease in the body. Second, the 777% increase of total CoQ10 levels measured after taking QH-absorb is more than double the levels achieved by even the best CoQ10 supplements. This suggests QH-absorb is at least twice as efficient in raising blood CoQ10 levels.
Ubiquinol is safe
Scientists have understood the value of ubiquinol for decades. It has just taken that long to figure out a way to stabilize ubiquinol so it can be formulated into a nutritional supplement product. Toxicity studies have shown little problem with taking ubiquinol directly, even at high doses. Plasma ubiquinol levels appear to plateau after two to four weeks of daily ingestion and then return near to baseline two weeks after daily ingestion is discontinued. It also appears that supplementation with ubiquinol does not reduce CoQ10 biosynthesis.
Jarrow Formulas QH-absorb is made with ubiquinol the more bioavailable, active-antioxidant form of CoQ10. It utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorption beyond that of ubiquinol alone.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
Should I worry about my cholesterol levels?Recently, new guidelines were introduced for what is deemed to be a healthy cholesterol level. While formerly, it was adviced to introduce cholesterol lowering drugs when your 'bad' cholesterol level amounted to over 2.5 mmol/litre, that number now dropped to 1.8.
This big drop will probably result in a vast increase of people that are being administered cholesterol lowering drugs.
But what if I told you, cholesterol is a poor marker for heart health?
For decades, cholesterol testing has served as that warning for many. An elevated level of "bad" LDL cholesterol has been just the warning people needed to change their ways. It has played that role for several reasons. People like tests because the results seem objective. Reliable measurement of cholesterol is easy and relatively inexpensive. It makes sense biologically. LDL cholesterol, a protein-wrapped package containing fat and cholesterol, tends to slip out of the bloodstream and lodge in blood vessel walls, forming the plaque that leads to clots and heart attacks.
And it makes sense statistically. The correlation between lowering your LDL and lowering your chances of having a heart attack or developing other forms of heart disease is well documented. Indeed, exercise and dietary changes are good for the heart partly because they lower LDL cholesterol levels.
What is co-enzyme Q10 and why is it important for our health?
Co-enzyme Q10, mostly shortened to Q10 is present in almost every single cell of our body. The other name for Q10 is ubiquinone, which is derived from the Latin word ubiquitous ('everywhere').
Co-enzyme Q10 is important for cellular processes in which it helps to produce energy for growth and maintenance. Co-Q10 also works as an antioxidant that protects you from the same energy-making process it’s also involved in.
While your body is capable of producting co-enzyme Q10 from food, the ability to do so, declines with age. This is why Q10 is called a conditionally essential nutrient, meaning it is required to be supplemented as we grow old.
take 1 to 3 softgels per day, one with each meal, or as directed by your qualified health care consultant.
contains per daily serving (1 softgel)
Ubiquinol Q10 (Kaneka QH) 100mg †
† = Recommended Daily Intake not established
active ingredients (active coQ10/ ubiquinol), filler (Medium Chain Triglycerides (MCT), sunflower lecithin, beeswax, rosemary extract), antioxidant (natural mixed tocopherol, ascorbylpalmitate), softgel capsule (bovine gelatin, glycerin and water), light barrier (caramel and carob)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)