Pterostilbene 60 capsules - active ingredient in resveratrol | Jarrow Formulas
Jarrow Formulas trans-Pterostilbene as Silbinol® which is a 100% natural trans-pterostilbene extracted from the heart wood of Pterocarpus marsupium. Pterostilbene is a methylated form of resveratrol, with greater uptake and metabolic stability in the body.
trans-Pterostilbene is a calorie-restriction mimetic that activates the sirtuin pathway..
what is pterostilbene?
Pterostilbene is a methylated natural-occurring form of resveratrol and has better uptake and metabolic stability in the body. Pterostilbene is a calorie restriction mimetic that activates the sirtuin pathway. Emerging science suggests that pterostilbene may exhibit special benefits in brain function and health.
who can benefit from Pterostilbene?
Adults seeking dietary support for dietary, cardiovascular or neurological health
what distinguishes Pterostilbene?
• made with Silbinol pterostilbene
• 100% natural dimethylresveratrol
• 50mg pterostilbene per serving
Silbinol® is a registered trademark of Sabinsa Corporation.
Pterostilbene (terro-STILL-bean) is found naturally in blueberries, grapes, and in the bark of the Indian Kino Tree (Pterocarpus marsupium). The name Pterocarpus derives from ancient Greek and means “wing fruit”, referring to the shape of the seedpods in this genus.
Preparations of the Indian Kino Tree have been used in Ayurvedic medicine for centuries in relation to inflammation and blood-sugar health. Similarly resveratrol, a structural cousin of pterostilbene, has been touted for effects related to the heart.
Pterostilbene vs. resveratrol
Pterostilbene has been shown to have the same antioxidant potential as resveratrol in a standard assay of antioxidant potential (Trolox). However, the two methylated hydroxyl groups make pterostilbene more lipophilic and less susceptible to conjugation-induced degradation; this leads to a greater half-life in the body compared to resveratrol (105 vs. 14 minutes).
These specific structural differences seem to make resveratrol more adept at combating reactive oxygen species (ROS) in whole blood and lymphocytes and pterostilbene better at targeting extracellelular ROS. Such extracellular ROS are often responsible for tissue damage with imbalanced inflammatory response, amongst other things.
As such, pterostilbene and resveratrol tend to be more complementary in their action than competitive. Work in animals has even suggested synergies between the two, along with quercetin. This is one reason both are included, along with quercetin and other components found in grapes, in a related Jarrow Formulas product: Resveratrol Synergy
Matters of the heart
Reduced oxidative stress and a properly modulated inflammatory response seem to be at the root of enduring health, particularly cardiovascular health. In vitro and animal studies suggest pterostilbene has positive effects on multiple inflammation-related biomarkers. But as we know, a healthy heart and network of blood vessels also involves balanced levels of blood lipids and blood sugar.
It’s understood that chronically high plasma levels of glucose lead to advanced glycation end products (AGE), which in turn cause the deterioration of bodily tissues, and an increased risk of developing insulin resistance. Pterostilbene seems to offer some protection from AGEs and may offer protection against metabolic change associated with elevated blood sugar.
When it comes to blood-lipids, pterostilbene has been found to activate peroxisome proliferator-activated receptor alpha (PPAR?). PPAR? is involved with blood-lipid regulation, synthesis and metabolism; in vitro and animal studies suggest that through this interaction pterostilbene can have positive effects on blood-lipid levels. A placebo-controlled human trial is underway at the University of Mississippi Medical Center that is seeking to determine the effect of pterostilbene on cholesterol, blood pressure and oxidative stress.
pTip-pTop brain health
Emerging research suggests that pterostilbene may have something to offer brains too. For instance, pterostilbene has been found to protect against a decrease in release of the neurotransmitter dopamine following exposure to an oxidative stressor (hydrogen peroxide).
In rats, pterostilbene leads to a decrease in the distance traveled and a decrease in the time to get to a platform between two trials in the Morris water maze test (i.e. suggesting memory support). How this may work remains an open question, but it is known that PPAR? agonists, like pterostilbene, confer a protective effect on cortical areas of the brain, like the hippocampus. So it’s possible a similar mechanism could be at the root of both brain and cardiovascular effects.
It has been known for some time that caloric restriction has positive effects on diseases of aging, and even aging itself, in a wide-range of organisms. One set of genes altered by caloric restriction (and whose activity has been associated with aging) is the sirtuins, one of which is SIRT1. Experimental evidence originating at Harvard, and later GlaxoSmithKline, suggests that resveratrol and its analogues have a similar effect on SIRT1 and may affect the process of aging in a similar way. Some doubt has been cast on this mechanism with the suggestion that the SIRT1 activity was merely an artifact produced by the chemical probes utilized in the experiments. Resveratrol, but not pterostilbene, was used in this work. Nonetheless, publications in the pipeline are expected to demonstrate that pterostilbene does have direct SIRT1 activating activity.
Pterostilbene is a methylated naturally-occurring form of resveratrol and has better uptake and metabolic stability in the body. Pterostilbene is a calorie restriction mimetic that activates the sirtuin pathway. Emerging science suggests that pterostilbene may exhibit special benefits in brain function and heart health.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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Set point and holiday weight gain
Tips and tricks to keep your house cool without airconditioning
After having survived the hottest two weeks of the past century, and hearing about the deliberate choice to switch of the power in some areas of California as it became impossible to match the demand for electricity, due to the massive use of airconditioning, this week's topic had to be about how to keep your house and yourself cool without needing to rely on energy-guzzling airconditioning.
How to make better food and lifestyle choices
Zinc and HCQ
In the past few months, nearly everyone will have become familiar with the malaria drug hydroxychloroquine (HCQ) and how it has been welcomed as a miracle drug, only to be set aside as being too dangerous to expose sick patients with underlying cardiovascular diseases to it.
Upon learning how HCQ is supposed to be used in this crisis, I was flabbergasted to read how HCQ was put to use by itself, as a drug on its own. True enough, HCQ is a malaria drug, but it was not just meant to be used as a curative medicin on its own for COVID-19 but as a messenger to transport the true miracle mineral, zinc into cells.
The now famous Zelenko protocol which uses HCQ , azithromycin and zinc as well as a number of other essential vitamins and minerals, was never meant to be used in hospital either, but for use by doctors on patients who had just fallen ill.
Now the researchers who discredited HCQ in the Lancet article have been debunked as having used fraudulous data in order to promote a much more expensive drug in which one of the authors had a vested interested, we think it is about time to explain a thing or two on why and how HCQ is used in combination with zinc.
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
Take 1 capsule per day or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
pterostilbene (dimethylresveratrol) 50mg †
from 56mg of Pterocarpus marsupium (heart wood) Silbinol®
RDI = Recommended Daily Intake not established
active ingredients (pterostilbene), filler (cellulose), anti-coagulant (silicon dioxide), filler (vegetable magnesium stearate), capsule (hydroxylpropylmethylcellulose)
store in a cool, dry place
keep out of reach of young children
NOTE: If you have a medical condition (especially diabetes or being treated for glucose control), are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your health care practitioner before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans