PQQ 20mg 60 capsules value-size - pyrroloquinoline quinone | Jarrow Formulas

PQQ 20mg 60 capsules value-size - pyrroloquinoline quinone | Jarrow Formulas

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brand ingredient:BioPQQ®
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Jarrow PQQ 20mg 60 capsules (pyrroloquinoline quinone) is an important antioxidant, promoting the creation of new mitochondria, and supports heart health and cognitive function.

For superior benefits, take with Jarrow Formulas QH-absorb.

BioPQQ™ is a trademark of MGC (Japan)

background reading

PQQ (pyrroloquinoline quinone), a powerful and focused anti-oxidant, is especially important in the mitochondria of cells. It is considered by some authorities to be an essential nutrient. PQQ promotes the creation of new mitochondria, a process known as mitochondrial biogenesis. This nutrient supports heart health and cognitive function.

An Essential Nutrient?
PQQ is a lipophilic antioxidant first recognized in the late 1970s as having cofactor functions acting in conjunction with important plant and animal enzymes. These cofactor functions are sufficiently important, in fact, to have led many researchers to propose PQQ as an essential dietary factor or even a vitamin. Until recently, it was controversial whether PQQ could be synthesized by humans and other higher mammals. Current reviews describe roles for PQQ in the regulation of cellular growth and differentiation, as a nutrient important in redox signaling and as having a “vitamin” function in stress tolerance. These functions, in turn, lead to benefits in the areas of cardiovascular and cognitive health.

Antioxidant Support for Heart Function
The body depends upon a vast number of repeated oxidation/reduction reactions, processes collectively known as redox cycling. CoQ10 is the best known of redox-cycling nutrients. In the mitochondria, there is constant movement from ubiquinone (oxidized form) to ubiquinol (reduced form) and back again to carry electrons – that is, transport energy for the creation of ATP (adenosine triphosphate) – in the electron transport chain. PQQ similarly acts as an intermediate in hundreds - or even thousands - of such reactions, a role that places it in the center of the body’s antioxidant and free radical scavenging operations.

Free radicals are a byproduct of energy production in general and are generated in the greatest quantities in the mitochondria, the organelles in which most of the body’s energy is generated. The heart, which is always active, therefore, is a major site of free radical generation and in need of constant protection. Researchers have examined possible roles for PQQ in the heart and have concluded that “PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent.”
In particular, it has been determined that PQQ protects mitochondria from ischemia/reperfusion oxidative damage. This mitochondrial and cellular protection appears to be associated with better blood flow to the heart muscle.

Cognitive Benefits
The brain, like the heart, is an energy-intensive organ. PQQ has been evaluated in areas such as neuroprotection, with positive results. As expected, PQQ suppresses the excessive generation of a number of radicals, including the extremely harmful peroxynitrite radical.
In both animal and clinical experiments, PQQ has exhibited positive effects in the areas of learning and memory. Animals fed a PQQ-supplemented diet and then subjected to oxidative stress were more proficient learners in the Morris water maze test, a standard measurement of learning capacity. CoQ10 supplementation in this model improved learning when the animals were vitamin E deficient, but only the PQQ animals maintained better longer-term memory than did the controls. Importantly, findings of this nature are not limited to animal models. Memory, attention and cognition decline with age, at least in part due to oxidative stress. The combination of 20 mg PQQ plus CoQ10 in one clinical trial was sufficient to yield substantial benefits to human test subjects in all three areas.

Mitochondrial Biogenesis
Because of their role in energy production and the resulting generation of oxidants and free radicals, the mitochondria are vulnerable to damage due to their normal activities. With age, the number of functional mitochondria decline. Aging muscle tissue, for example, is less strong and recovers from challenges more slowly because the number of functional mitochondria in any given unit of tissue is lower and, thus, the production of energy for cellular repair is reduced.
The best known methods of stimulating the production in new fully functional mitochondria are extreme physical exercise and caloric restriction. Neither of these options appeal to most individuals.

PQQ is valuable as a mitochondrial antioxidant that works particularly well with CoQ10. Even more importantly, PQQ promotes the formation of new mitochondria. One vector of action is via increased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha or PGC-1α. A second is through activation of the signaling protein known as cAMP-response element-binding protein or CREB. Researchers have concluded that the “ability of PQQ to stimulate mitochondrial biogenesis accounts in part for the action of this compound and suggests that PQQ may be beneficial in mitochondrial dysfunction.”

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The true danger of COVID-19 vaccines : why we should avoid leaky vaccines

Two weeks ago I wrote in my blog on how I did not want a vaccine out of madness because governments won't allow the use of HCQ or ivermectin, both of which are both safe and cheap treatments against COVID-19.
However, I said to not see anything wrong in the vaccine itself. By now I've changed my mind. No, I don't actually deem mRNA vaccines to be unsafe, nor am I too worried about the very rare side-effects of clotting.

What truly spooked me is the fact these are 'leaky' vaccines, which allows viruses to still infect people despite being vaccinated. They just won't get sick, but can become hosts of viruses that may still infect unvaccinated people. Who , in the end no longer will have any other choice but to get vaccinated when a virus has mutated into a too dangerous variant.

At least this is the theory from dr Geert Vanden Bossche, a prominent virologist who spoke out against massive vaccination.

Why is the fact those vaccines are leaky so scary? Let me explain with an article on Marek's disease in chickens.

Forget about exercising to lose weight: you can't outrun a bad diet! 

A few days ago, an article showed up in my newsfood about a remarkable result of research done on the Hadza tribe in Tanzania, which still leads a traditional hunter-gatherer lifestyle. 
Despite walking an average of a multiple of ten thousands of steps every day, they barely need more calories than the average couch potato in a Western country. 
That same day I discussed with an old friend who had read the same news story. He told me how he had trained for a marathon in the past, but barely dropped any weight while doing so. Only when he spent a week on liquid foods at a spa, he succeeded in losing weight which he mostly thanks to the relaxed environment. Otherwise it was next to impossible. Apparently his body really clung to its precious body fat! 
But how was this possible? We didn't really know though we had our suspicions. I I could tell much about the same story. Yes, I'd drop weight pretty fast in the first few weeks of the cycling season or on a longer cycling holiday, but would get stuck at my regular (still too heavy) summer weight while I wasn't really inhaling tons of food. Except then for the Route des Cent Cols during which I could barely eat enough to stay fit and sleep well for all those mountains. 
Let's find out more about this particular research!
When Herman Pontzer set off for the rugged savannah of Tanzania to spend a summer with the local Hadza people, he thought he knew what he would find. As an evolutionary biologist, his aim was to measure how the Hadza’s hunter-gatherer lifestyle causes them to burn more energy. Because we all know the more exercise you do, the more calories you burn and the slimmer you become, right? Well no, not exactly.
Don’t expect any meaningful weight change in the long term from exercise alone.”
What Pontzer and his fellow researchers discovered flew in the face of received wisdom about how our metabolism works. Although the Hadza lead far more active lives than ours – routinely walking long distances, they undertake more physical activity daily than the typical American does in a week – their energy expenditure was no greater. They were burning the same number of calories as men and women from industrialised populations. Our bodies, concluded Pontzer, seem to maintain daily energy expenditure within a narrow window, no matter what lifestyle we lead. While obesity is largely caused by overconsumption, it appears there’s little we can do to change the calories we burn.

Set point and holiday weight gain

At the time of writing this article the first week of advent has almost finished. In this week most people will have started decorating their homes for the holiday season that is upon us.
Though for most this period may not be as festive as it normally is, since it is not allowed to organize large gatherings because of COVID-19, we can still try to make the most of it and indulge in the small pleasures of life. 
Quite a lot of people that are trying to become fit and trim worry about the holiday season and what damage it will do to their progress: how can they avoid weight gain during those days? 
We can reassure the worryworts: you will be fine to indulge on those special days. With emphasis on 'special' days as nothing spectacular will happen when you eat normal on the other days. The bigger problem is when you spread out those days over an extended period of say two to three weeks. 
But even with a longer period of dietary negligence, most people notice it is surprisingly easy to get rid of the extra holiday weight, due to a wonderful (and scary) phenomenon called 'set point'. 

Heart disease: what are the differences between men and women?

Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.

This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.

For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.

Determining heart disease risk in women

Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.

Traditional risk factors common to both women and men:

  • obesity
  • smoking
  • diabetes
  • high blood pressure
  • family history
  • metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
  • high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors

Some risk factors that relate specifically to women or that can affect women disproportionately include:

  • relatively high testosterone levels prior to menopause
  • increasing hypertension during menopause
  • autoimmune diseases such as rheumatoid arthritis – more common in women than in men
  • stress and depression are more common among women
  • low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself

What is co-enzyme Q10 and why is it important for our health?

Co-enzyme Q10, mostly shortened to Q10 is present in almost every single cell of our body. The other name for Q10 is ubiquinone, which is derived from the Latin word ubiquitous ('everywhere').

Co-enzyme Q10 is important for cellular processes in which it helps to produce energy for growth and maintenance. Co-Q10 also works as an antioxidant that protects you from the same energy-making process it’s also involved in.

While your body is capable of producting co-enzyme Q10 from food, the ability to do so, declines with age. This is why Q10 is called a conditionally essential nutrient, meaning it is required to be supplemented as we grow old.

Boost energy levels in your body with PQQ

Our cellular energy comes from mitochondria, which are the powerhouses of the cell. Mitochrondria are the tiny organelles working to produce cellular ATP, the energy currency of any living cells.

Aging gracefully

Ever since mankind exists, one of our biggest desires is to age gracefully and therefore we are interested in the peculiarities of populations that grow very old, seemingly without effort.

recommended use
take 1 capsule per day, or as directed by your qualified health care professional.

contains per daily serving (1 capsule)
Pyrroloquinoline Quinone 20mg†

† = Recommended Daily Intake not established

active ingredients (pyrroloquinoline quinone), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), capsule (BSE-free bovine gelatin)

store in a cool, dry place
keep out of reach of young children

If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.

allergy information
contains no familiar allergens (wheat, gluten, lupin, soy, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

contains gelatin

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