PQQ 20mg 60 capsules value-size - pyrroloquinoline quinone | Jarrow Formulas
Jarrow PQQ 20mg 60 capsules (pyrroloquinoline quinone) is an important antioxidant, promoting the creation of new mitochondria, and supports heart health and cognitive function.
For superior benefits, take with Jarrow Formulas QH-absorb.
BioPQQ™ is a trademark of MGC (Japan)
PQQ (pyrroloquinoline quinone), a powerful and focused anti-oxidant, is especially important in the mitochondria of cells. It is considered by some authorities to be an essential nutrient. PQQ promotes the creation of new mitochondria, a process known as mitochondrial biogenesis. This nutrient supports heart health and cognitive function.
An Essential Nutrient?
PQQ is a lipophilic antioxidant first recognized in the late 1970s as having cofactor functions acting in conjunction with important plant and animal enzymes. These cofactor functions are sufficiently important, in fact, to have led many researchers to propose PQQ as an essential dietary factor or even a vitamin. Until recently, it was controversial whether PQQ could be synthesized by humans and other higher mammals. Current reviews describe roles for PQQ in the regulation of cellular growth and differentiation, as a nutrient important in redox signaling and as having a “vitamin” function in stress tolerance. These functions, in turn, lead to benefits in the areas of cardiovascular and cognitive health.
Antioxidant Support for Heart Function
The body depends upon a vast number of repeated oxidation/reduction reactions, processes collectively known as redox cycling. CoQ10 is the best known of redox-cycling nutrients. In the mitochondria, there is constant movement from ubiquinone (oxidized form) to ubiquinol (reduced form) and back again to carry electrons – that is, transport energy for the creation of ATP (adenosine triphosphate) – in the electron transport chain. PQQ similarly acts as an intermediate in hundreds - or even thousands - of such reactions, a role that places it in the center of the body’s antioxidant and free radical scavenging operations.
Free radicals are a byproduct of energy production in general and are generated in the greatest quantities in the mitochondria, the organelles in which most of the body’s energy is generated. The heart, which is always active, therefore, is a major site of free radical generation and in need of constant protection. Researchers have examined possible roles for PQQ in the heart and have concluded that “PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent.”
In particular, it has been determined that PQQ protects mitochondria from ischemia/reperfusion oxidative damage. This mitochondrial and cellular protection appears to be associated with better blood flow to the heart muscle.
The brain, like the heart, is an energy-intensive organ. PQQ has been evaluated in areas such as neuroprotection, with positive results. As expected, PQQ suppresses the excessive generation of a number of radicals, including the extremely harmful peroxynitrite radical.
In both animal and clinical experiments, PQQ has exhibited positive effects in the areas of learning and memory. Animals fed a PQQ-supplemented diet and then subjected to oxidative stress were more proficient learners in the Morris water maze test, a standard measurement of learning capacity. CoQ10 supplementation in this model improved learning when the animals were vitamin E deficient, but only the PQQ animals maintained better longer-term memory than did the controls. Importantly, findings of this nature are not limited to animal models. Memory, attention and cognition decline with age, at least in part due to oxidative stress. The combination of 20 mg PQQ plus CoQ10 in one clinical trial was sufficient to yield substantial benefits to human test subjects in all three areas.
Because of their role in energy production and the resulting generation of oxidants and free radicals, the mitochondria are vulnerable to damage due to their normal activities. With age, the number of functional mitochondria decline. Aging muscle tissue, for example, is less strong and recovers from challenges more slowly because the number of functional mitochondria in any given unit of tissue is lower and, thus, the production of energy for cellular repair is reduced.
The best known methods of stimulating the production in new fully functional mitochondria are extreme physical exercise and caloric restriction. Neither of these options appeal to most individuals.
PQQ is valuable as a mitochondrial antioxidant that works particularly well with CoQ10. Even more importantly, PQQ promotes the formation of new mitochondria. One vector of action is via increased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha or PGC-1α. A second is through activation of the signaling protein known as cAMP-response element-binding protein or CREB. Researchers have concluded that the “ability of PQQ to stimulate mitochondrial biogenesis accounts in part for the action of this compound and suggests that PQQ may be beneficial in mitochondrial dysfunction.”
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Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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The true danger of COVID-19 vaccines : why we should avoid leaky vaccinesTwo weeks ago I wrote in my blog on how I did not want a vaccine out of madness because governments won't allow the use of HCQ or ivermectin, both of which are both safe and cheap treatments against COVID-19.
However, I said to not see anything wrong in the vaccine itself. By now I've changed my mind. No, I don't actually deem mRNA vaccines to be unsafe, nor am I too worried about the very rare side-effects of clotting.
What truly spooked me is the fact these are 'leaky' vaccines, which allows viruses to still infect people despite being vaccinated. They just won't get sick, but can become hosts of viruses that may still infect unvaccinated people. Who , in the end no longer will have any other choice but to get vaccinated when a virus has mutated into a too dangerous variant.
At least this is the theory from dr Geert Vanden Bossche, a prominent virologist who spoke out against massive vaccination.
Why is the fact those vaccines are leaky so scary? Let me explain with an article on Marek's disease in chickens.
Forget about exercising to lose weight: you can't outrun a bad diet!
Set point and holiday weight gain
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
What is co-enzyme Q10 and why is it important for our health?
Co-enzyme Q10, mostly shortened to Q10 is present in almost every single cell of our body. The other name for Q10 is ubiquinone, which is derived from the Latin word ubiquitous ('everywhere').
Co-enzyme Q10 is important for cellular processes in which it helps to produce energy for growth and maintenance. Co-Q10 also works as an antioxidant that protects you from the same energy-making process it’s also involved in.
While your body is capable of producting co-enzyme Q10 from food, the ability to do so, declines with age. This is why Q10 is called a conditionally essential nutrient, meaning it is required to be supplemented as we grow old.
Boost energy levels in your body with PQQOur cellular energy comes from mitochondria, which are the powerhouses of the cell. Mitochrondria are the tiny organelles working to produce cellular ATP, the energy currency of any living cells.
take 1 capsule per day, or as directed by your qualified health care professional.
contains per daily serving (1 capsule)
Pyrroloquinoline Quinone 20mg†
† = Recommended Daily Intake not established
active ingredients (pyrroloquinoline quinone), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), capsule (BSE-free bovine gelatin)
store in a cool, dry place
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.
contains no familiar allergens (wheat, gluten, lupin, soy, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)