PQQ 20mg 30 capsules - pyrroloquinoline quinone | Jarrow Formulas

PQQ 20mg 30 capsules - pyrroloquinoline quinone | Jarrow Formulas

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brand:Jarrow Formulas
brand ingredient:BioPQQ®
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Jarrow PQQ 20mg 30 capsules (pyrroloquinoline quinone) is an important antioxidant, promoting the creation of new mitochondria, and supports heart health and cognitive function.

For superior benefits, take with Jarrow Formulas QH-absorb.

BioPQQ™ is a trademark of MGC (Japan)

background reading

PQQ (pyrroloquinoline quinone), a powerful and focused anti-oxidant, is especially important in the mitochondria of cells. It is considered by some authorities to be an essential nutrient. PQQ promotes the creation of new mitochondria, a process known as mitochondrial biogenesis. This nutrient supports heart health and cognitive function.

An Essential Nutrient?
PQQ is a lipophilic antioxidant first recognized in the late 1970s as having cofactor functions acting in conjunction with important plant and animal enzymes. These cofactor functions are sufficiently important, in fact, to have led many researchers to propose PQQ as an essential dietary factor or even a vitamin. Until recently, it was controversial whether PQQ could be synthesized by humans and other higher mammals. Current reviews describe roles for PQQ in the regulation of cellular growth and differentiation, as a nutrient important in redox signaling and as having a “vitamin” function in stress tolerance. These functions, in turn, lead to benefits in the areas of cardiovascular and cognitive health.

Antioxidant Support for Heart Function
The body depends upon a vast number of repeated oxidation/reduction reactions, processes collectively known as redox cycling. CoQ10 is the best known of redox-cycling nutrients. In the mitochondria, there is constant movement from ubiquinone (oxidized form) to ubiquinol (reduced form) and back again to carry electrons – that is, transport energy for the creation of ATP (adenosine triphosphate) – in the electron transport chain. PQQ similarly acts as an intermediate in hundreds - or even thousands - of such reactions, a role that places it in the center of the body’s antioxidant and free radical scavenging operations.

Free radicals are a byproduct of energy production in general and are generated in the greatest quantities in the mitochondria, the organelles in which most of the body’s energy is generated. The heart, which is always active, therefore, is a major site of free radical generation and in need of constant protection. Researchers have examined possible roles for PQQ in the heart and have concluded that “PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent.”
In particular, it has been determined that PQQ protects mitochondria from ischemia/reperfusion oxidative damage. This mitochondrial and cellular protection appears to be associated with better blood flow to the heart muscle.

Cognitive Benefits
The brain, like the heart, is an energy-intensive organ. PQQ has been evaluated in areas such as neuroprotection, with positive results. As expected, PQQ suppresses the excessive generation of a number of radicals, including the extremely harmful peroxynitrite radical.
In both animal and clinical experiments, PQQ has exhibited positive effects in the areas of learning and memory. Animals fed a PQQ-supplemented diet and then subjected to oxidative stress were more proficient learners in the Morris water maze test, a standard measurement of learning capacity. CoQ10 supplementation in this model improved learning when the animals were vitamin E deficient, but only the PQQ animals maintained better longer-term memory than did the controls. Importantly, findings of this nature are not limited to animal models. Memory, attention and cognition decline with age, at least in part due to oxidative stress. The combination of 20 mg PQQ plus CoQ10 in one clinical trial was sufficient to yield substantial benefits to human test subjects in all three areas.

Mitochondrial Biogenesis
Because of their role in energy production and the resulting generation of oxidants and free radicals, the mitochondria are vulnerable to damage due to their normal activities. With age, the number of functional mitochondria decline. Aging muscle tissue, for example, is less strong and recovers from challenges more slowly because the number of functional mitochondria in any given unit of tissue is lower and, thus, the production of energy for cellular repair is reduced.
The best known methods of stimulating the production in new fully functional mitochondria are extreme physical exercise and caloric restriction. Neither of these options appeal to most individuals.

PQQ is valuable as a mitochondrial antioxidant that works particularly well with CoQ10. Even more importantly, PQQ promotes the formation of new mitochondria. One vector of action is via increased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha or PGC-1α. A second is through activation of the signaling protein known as cAMP-response element-binding protein or CREB. Researchers have concluded that the “ability of PQQ to stimulate mitochondrial biogenesis accounts in part for the action of this compound and suggests that PQQ may be beneficial in mitochondrial dysfunction.”

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Jarrow Formulas
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best before:
April 2022
  • gelatin caps
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  • hypo-allergenic
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  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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Heart disease: what are the differences between men and women?

Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.

This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.

For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.

Determining heart disease risk in women

Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.

Traditional risk factors common to both women and men:

  • obesity
  • smoking
  • diabetes
  • high blood pressure
  • family history
  • metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
  • high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors

Some risk factors that relate specifically to women or that can affect women disproportionately include:

  • relatively high testosterone levels prior to menopause
  • increasing hypertension during menopause
  • autoimmune diseases such as rheumatoid arthritis – more common in women than in men
  • stress and depression are more common among women
  • low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself

What are free radicals?

The body is under constant attack from oxidative stress. Oxygen in the body splits into single atoms with unpaired electrons. Electrons like to be in pairs, so these atoms, called free radicals, scavenge the body to seek out other electrons so they can become a pair. This causes damage to cells, proteins and DNA.

Free radicals are associated with human disease, including cancer, atherosclerosis, Alzheimer's disease, Parkinson's disease and many others. They also may have a link to aging, which has been defined as a gradual accumulation of free-radical damage.

Substances that generate free radicals can be found in the food we eat, the medicines we take, the air we breathe and the water we drink. These substances include fried foods, alcohol, tobacco smoke, pesticides and air pollutants.

Free radicals are the natural byproducts of chemical processes, such as metabolism. Free radicals can be seen as as waste products from various chemical reactions in the cell that when built up, harm the cells of the body.

Yet, free radicals are essential to life. The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders.

Why is natto a superfood?

When you think of Japanese cuisine, fresh, delicate flavours and intricately presented sushi food come to mind. Amidst all this loveliness, gooey, sticky and stinky fermented soybeans seem somewhat out of place.
Called natto, this stinky dish is lesser known in Europe, but some Japanese (sushi) restaurants offer it as part of their menu and some Asian supermarkets stock it as well.

Natto has a long history as a super food. This little-known Eastern health secret has been a staple in the Japanese diet for more than 1,000 years.
Nutritionally, natto does have a lot to offer. A serving provides the same amount of protein as a similar amount of beef, but with fewer calories.

Natto is a fermented soy food with a distinctive, powerful smell that has been described as similar in pungency to fermented ripe cheese. Or worse, like foot odour mixed with paint thinner.
While some love the taste and will eat it on its own, it's often served with condiments such as sliced green onions, wasabi or pickled ginger.
As a dish it often comes wrapped in rice and seaweed. In Japan, many eat natto at breakfast with rice and, sometimes, with mustard, soy sauce, broth, vegetables or a raw egg.

Natto is a food that divides Japan: half of the Japanese population hates it while the other half likes it.
Natto may not sound that appealing if you aren't a fan of funky flavours, but the growing body of research supporting its health benefits certainly is.

Boost energy levels in your body with PQQ

Our cellular energy comes from mitochondria, which are the powerhouses of the cell. Mitochrondria are the tiny organelles working to produce cellular ATP, the energy currency of any living cells.

Aging gracefully

Ever since mankind exists, one of our biggest desires is to age gracefully and therefore we are interested in the peculiarities of populations that grow very old, seemingly without effort.

recommended use
take 1 capsule per day, or as directed by your qualified health care professional.

contains per daily serving (1 capsule)
Pyrroloquinoline Quinone 20mg†

† = Recommended Daily Intake not established

active ingredients (pyrroloquinoline quinone), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), capsule (BSE-free bovine gelatin)

store in a cool, dry place
keep out of reach of young children

If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.

allergy information
contains no familiar allergens (wheat, gluten, lupin, soy, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

contains gelatin

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