Nattokinase 120 capsules helps maintain normal blood flow | NOW
NOW Nattokinase 100mg is an enzyme isolated from natto, a traditional Japanese fermented soy food.
Natto has been consumed for thousands of years for its numerous health promoting properties.
More recently, both clinical and non-clinical studies have demonstrated that nattokinase can help to promote heart and circulatory health by supporting normal blood clotting functions.
NOW® Nattokinase is derived from non-GMO soy and has 2,000 FUs (Fibrinolytic Units) per 100 mg serving.
• helps maintain normal blood flow
• keeps arteries healthy and eleastic
• 2000 fibrinolytic units of activity
As a source of nutrients, natto is an interesting study. Traditionally, it has been valued as a cardiovascular tonic. Modern biomedical research has teased out some of these effects. Most important are the two constituents often associated with natto 1) vitamin K2 (in the form of MK-7) and 2) nattokinase, a fibrin-dissolving enzyme. One of vitamin K’s most prominent roles is assisting with blood-clotting by helping to produce clotting-factors. Nattokinase, however, is involved in the opposite process. This is sometimes the conundrum with natto.
In fact, many health practitioners rightly advise patients taking blood thinning medication to avoid natto due to the vitamin K content. This is despite the support nattokinase may offer in helping balance clot formation and degradation. Others with soy allergies, or those who simply have a distaste for natto, cannot access the health benefits of natto.
To clot or not to clot
The biochemical cascade that leads to blood-clotting, the first step in a wound healing, is both complex and life-preserving. Without it, a minor cut could lead to an untimely demise. At the center of this process is fibrin, a fibrous protein produced by an enzyme, thrombin, which is kicked-into gear when the body senses clotting is required. Upon healing the fibrin is covered over by normal tissue, while another set of proteins (e.g. plasmin) helps to dissolve the now unnecessary fibrin. This is the normal process at the site of a wound, but, as we age, the ability to dissolve fibrin tends to fall out of balance with the ability to create fibrin.
When fibrin accumulates in blood vessels, a process that is essential for normal maintenance and repair, blood begins to flow less freely. This can reduce oxygen flow to heart and brain tissue, resulting in suboptimal function. Meanwhile, the excess fibrin can make blood vessels less pliable and lead to elevated blood pressure. Nattokinase helps to maintain proper blood viscosity, fibrin levels and healthy circulation, all effects that draw support from research conducted at the National Cardiovascular Center in Japan.
Nattokinase in action
Nattokinase is believed to do a number of things in supporting circulatory health. First, it acts as a natural fibrinolytic (clot-dissolving) enzyme that helps support the body’s ability to regulate fibrin. In fact, this is why nattokinase is measured in terms of fibrinolytic units (FU). And some research suggests that nattokinase does this more effectively than the body’s own enzyme, plasmin, for this purpose.
Second, nattokinase appears to support normal levels of plasminogen activator inhibitor 1 (PAI-1). High levels of PAI-1 can negatively impact fibrin degradation by reducing the plasminogen levels that are critical to the production of plasmin. By maintaining normal levels of PAI-1, nattokinase supports the body’s own fibrin-dissolving mechanisms.
More recently, it has been suggested that fragments of nattokinase have complementary effects on circulatory health. Researchers found that these fragments interacted with angiotensin II, a peptide hormone that helps regulate blood pressure via action on other enzymes such as renin and acetycholineesterase. Whole nattokinase does not do this. However, such an effect has been observed with protein fragments from other foods sources, such as sesame and milk, so it should not be a huge surprise. Nevertheless, it does appear that a large fraction of nattokinase is absorbed whole from the digestive tract.
A growing number of human studies suggest nattokinase is helping to maintain healthy fibrin levels, flexible blood vessels, proper blood viscosity, and normal cell aggregation.
Each capsule offers 2,000 Fibrinolytic Units. Nattokinase is a fibrinolytic enzyme that promotes healthy circulation by its effects on serine protease-mediated digestion of fibrin.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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take 1 capsule once or twice per day on an empty stomach
contains per daily serving (1 capsule)
nattokinase (2000 Fibrinolytic Units) 100mg †
- from natto-extract, derived from non-GMO soy)
does NOT contain vitamin K!
† = Recommended Daily Intake not established
active ingredient (natto-extract with nattokinase), filler (microcrystalline cellulose), v-capsule (hypromellose), filler (vegetable stearic acid), anticoagulant (silicon dioxide)
store in a cool, dry place
keep out of reach of young children
NOTE: Do not exceed 2 capsules per day without first consulting your healthcare professional.
For adults only. Do not use if pregnant or nursing, taking “blood thinning” medications (anticoagulants) (such as aspirin, warfarin, heparin), or if you have any ongoing bleeding/coagulation problems (including but not limited to: active ulcer, recent surgery/trauma, hemophilia).
Consult physician if you have a medical condition (including uncontrolled high blood pressure [equal to or higher than 200 mmHg/110 mmHg]).
nattokinase is derived from fermented soy
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans