NAC 500mg 200 capsules - N-acetyl-cysteine | Jarrow Formulas

NAC 500mg 200 capsules - N-acetyl-cysteine | Jarrow Formulas

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brand:Jarrow Formulas
best before:Feb 2023
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Jarrow Formulas NAC 500mg 200 capsules with N-Acetyl L-Cysteine, a sulfur amino compound which plays an all important role in the production of the body dominant and essential antioxidant Glutathione. Optimal Glutathione levels are important for a healthy immune system and the cell defense against viral infections.

NAC's primary efficacy is shown when it is needed to regenerate glutathione after overdoses of certain NSAIDs like aspirin or acetaminophen which may lead to a depletion of liver glutathione stores. The more stress is placed on the liver, the faster this may lead to a dysfunctional liver and cause death.

People who cough up a lot of sputum know NAC as an agent capable of reducing the sulfur found in mucus and break it down to a more liquid form.

In athletic circles NAC is widely used as an anti-oxidant. Some athletes claim to perform better with NAC supplementation than without. Plausibly caused by the vasodilating effects of acetylcysteine. But NAC supplementation has further use as it has shown to slow down platelet aggregation.

N-Acetyl Cysteine is a better alternative than cysteine which can be obtained from dietary sources like egg whites or dairy products. Simply due to the fact that it is rapidly absorbed from the gut and finds its way to the liver and other areas in the body where L-cysteine is needed. It also works twice as long in the body than just dietary cysteine.

key benefits
• strengthens the immune system
• n-acetyl cysteine boost ntric oxide synthesis which causes increased blood flow to the muscles
• benefits people with breathing problems
• slows down platelet aggregation
• increases glutathione stores which in turn help to protect the liver from overdose on
  drugs like acetaminophen and other NSAIDs

background reading

NAC - a better source of L-cysteine
N-acetyl-L-cysteine (NAC) is a stable form of the amino acid L-cysteine. NAC is cysteine that has been modified with an acetyl group, which stabilizes and increases the bioavailability of many compounds (e.g., aspirin, omega-3 fatty acids). In enzymes, cysteine interacts with iron and zinc to regulate processes associated with respiration, energy production, immune surveillance and repair functions in all tissues.

L-cysteine is a sulfur-containing amino acid that can be produced by the body from the essential amino acid methionine. However, inadequate methionine in the diet, low selenium intake, chronic disease, and advancing age reduce the body’s ability to convert methionine to cysteine. Likewise, stress and environmental toxins may increase the need for cysteine beyond the body’s capacity for conversion. NAC is preferred to L-cysteine as a supplement because of its stability and solubility.


Glutathione: Cleansing & Protecting the Body
NAC supplies readily available L-cysteine, which acts as an antioxidant itself or as a precursor to glutathione. Glutathione is one of the body’s most important and abundant antioxidants and detoxification agents. Making cysteine more available to the body in the form of NAC encourages the production of glutathione.

As an antioxidant, cysteine acts as an electron donor and acceptor to neutralize uncontrolled free radicals without becoming reactive or toxic itself. This is also one aspect of its functionality as a constituent of glutathione. For example, the transformation of superoxide or peroxide to water requires glutathione to be oxidized. Then, enzymes in the body reactivate oxidized glutathione, so it is ready to scavenge yet more free radicals.

Glutathione is a critical Phase II detoxification agent, meaning glutathione attaches to lipid-soluble toxins to make them more easily excreted from the body. One example of this is acetaminophen metabolism in which the metabolite N-acetyl-p-benzoquinone imine (NAPQI) is conjugated by glutathione. But, when glutathione levels are depleted, NAPQI damages liver cells. It is important to note that in hospital practice, NAC is given rather than reduced glutathione to support blood levels of glutathione.

Bolstering the Liver
Cysteine, both alone and as a component of glutathione, can neutralize a class of chemicals known as aldehydes, which are encountered in air pollution and produced upon the metabolism of some drugs and alcohol in the liver. NAC is, therefore, important for maintaining the body’s antioxidant defenses in the face of everyday assaults.

One aldehyde in particular, acetaldehyde, has been associated with the symptoms of “hangover.” In fact, a decreased ability to metabolize acetaldehyde to acetic acid causes the facial flush and negative physical symptoms some are prone to when drinking. The sulfhydryl group of NAC directly conjugates acetaldehyde, helping to protect glutathione levels and glutathione enzymes that normally deteriorate after ingesting alcohol. The direct antioxidant action of NAC has also been implicated in protection from the alcohol-induced increase in lipid peroxidation and inflammation that is also associated with hangovers and other ill-effects of alcohol overuse.

NAC is routinely used in hospitals as an antidote to the pain reliever acetaminophen, particularly when ingested with alcohol, or taken in excessive amounts. Acetaminophen poisoning is one of the most common cause of calls to poison control centers in the United States. It causes severe damage to the liver, much the same as that caused by the toxic mushroom Amanita phalloides . NAC supports the health of liver tissue by replenishing liver glutathione levels.

Guarding the Lungs
NAC is also thought to offer benefits to respiratory health. Most commonly, it thins mucus that can accumulate in the mouth and throat by breaking the sulfur-sulfur bonds in proteins that impart viscosity to phlegm and mucus. But perhaps more importantly, research suggests that NAC can modulate immune and inflammatory responses to help protect the lungs when they come under assault.

N-acetyl-L-cysteine (NAC) is a powerful antioxidant amino acid and a precursor in the body to the critical antioxidant glutathione. Glutathione exerts a variety of protective effects, including detoxification and intracellular defense against oxidative stress. Substances known to reduce glutathione status are acetaminophen and alcohol.

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Jarrow Formulas
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Feb 2023
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  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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Particulate matter and your health

As the Dutch government decided to move away from natural fossilized energy sources, we are moving towards solar and wind energy.
Because solar and wind energy cannot provide all energy and a decision to also move away from natural gas, biomass plants seemed to be the perfect solution.

Biomass is plant or animal material used for energy production (electricity or heat). It can be purposely grown energy crops, wood or forest residues, waste from food crops (wheat straw), horticulture (yard waste), food processing (corn cobs), animal farming (manure, rich in nitrogen and phosphorus), or human waste from sewage plants.

Burning plant-derived biomass releases CO2, but it has still been classified as a renewable energy source in the EU and UN legal frameworks because photosynthesis cycles the CO2 back into new crops. In some cases, this recycling of CO2 from plants to atmosphere and back into plants can even be CO2 negative, as a relatively large portion of the CO2 is moved to the soil during each cycle.

However, over the past few months it has become clear how a lot of biomass comes from trees, that were previously pristine forests in the USA or the Baltics.
While in the best case, the use of biomass could even be CO2 negative, burning biomass will result in excessive CO2 output locally as well as of particulate matter.
This is why almost overnight, due to negative public opinion, politicians changed their mind. Too late though, there are already few hundred biomass plants that are being constructed due to substantial subsidies that were handed out, so we can expect a substantial worsening of air quality in the upcoming decade(s) because of the increased amount of particulate matter.

How to cure a hangover

Quite a lot of people wake up the day after a major holiday like the recent King's Day or Liberation Day with a hangover due to imbibing too much alcohol.
The most widespread assumption is that a hangover is caused by not drinking enough water, and therefore those that aren't drunk enough to remember what to do, will drink a few litres of water before going to bed or at least will try to do so the next morning. Other very popular cures are to drink a lot of coffee and eat a hearty egg-based breakfast. Another advice was heard on the radio from a Dutch food blogger who exclaimed how eating toast with honey is a definite cure for hangovers. Around the world a myriad of folk remedies exist for this ancient 'disease'.

Do these remedies actually work and are there some others you didn't think of?

Before we dive into that, let's first discuss the hangover itself.

Breathe in, breathe out!

Did you ever notice you don't have equal air flow through each nostril? Most people alternate between breathing through the left and the right nostril. The only time you are vividly aware of the existence of such a cycle is when you have congestion in just one side of the nose, which results in only being able to breathe more easily every few hours and then feel congested in the other period.

When is drinking alcohol bad for your health?

In the past decade we were told indulging in one or two glasses of alcohol (just one for women) a day is healthy. This was even one of the many recommendations in the national (Dutch) health guidelines. In the past year though, a drastic change occurred: the recommendation changed into zero to perhaps to a most one glass of alcohol a day! So, what gives?

How to eliminate toxins?

A while ago, there was a major uproar in the Dutch media about an advice given by a celeb health enthusiast to drink a glass of water with clay in order to 'detox' the body.
Unfortunately, while it is true that clay can bind to toxins, clay is not the best choice for two reasons. The clay itself can be polluted, but moreso, clay isn't the best option.

recommended use
take 1 capsule 1 or 2 times per day or as directed by your qualified health care consultant.

contains per daily serving (1 capsule)
n-acetyl l-cysteine 500 mg †

† = Recommended Daily Intake not established

active ingredient (pharmaceutical grade n-acetyl l-cysteine), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicium dioxide), capsule (hydroxypropylmethylcellulose)

keep dry and closed at normal room temperature away from light
keep away from young children

contra-indications and warning
Prolonged or elevated intake may alter liver function tests without affecting actual liver function. Inform your physician that you are ingesting NAC if you undergo liver function tests.
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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