Melatonin Sustain 1mg 120 tablets - melatonin for a slow and gradual absorption | Jarrow Formulas

Melatonin Sustain 1mg 120 tablets - melatonin for a slow and gradual absorption | Jarrow Formulas

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Retail price: 16,00
You save: 4,00
Price in points: 1200 points
brand:Jarrow Formulas
best before:June 2022
appearance:time-released, tablets
diet:vegan, hypo-allergenic
availability:limited availability
shipping costs:€3,75+ (NL) - €7,50+ (EU) - €20+ (world)
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Jarrow Formulas Melatonin Sustain contains melatonin, the hormone that is secreted by the pineal gland that aids biorhythm regulation. Biorhythm is disturbed by stress, crossing time zones and changing work shifts or even just the transition into and out of daylight saving time. Melatonin production also declines with age.

who may benefit from taking melatonin?
those that work in shifts or travel across time zones

what distinguishes Melatonin Sustain from other similar products?
Melatonin Sustain has a safe dose of melatonin and also contains vitamin B6 and magnesium for an even higher effectivity.
It also is produced as a sustained release tablet, so will be released slowly over time after ingestion.

background reading
Millions of Americans suffer from sleep difficulties, spending a fortune on sleeping pills despite side effects. Yet sleep problems can often be traced to by-products of modern life. Caffeine, alcohol and sedentary lifestyles have an impact, but so do light and other forms of electromagnetic radiation.

The production of melatonin by the human body falls and rises with the light-dark cycle in the environment. In fact, melatonin acts like a metronome, keeping time with the sun and allowing “scheduling” of physiological processes. This timekeeper role is the reason why melatonin is often referred to as a “chronobiotic.” Jet-lag is the most common way of understanding this experientially. But the impact of melatonin on sleep is just one aspect of this amazing molecule.

First, although melatonin possesses excellent oral bioavailability, it has a very short half-life (15-45 minutes) once it reaches the bloodstream. Together, this leads to blood levels that can be hundreds or thousands of times higher than produced by natural secretion, even when consuming only a few milligrams, and then those spiked levels drop off quickly. Melatonin Sustain overcomes these limitations with timely, balanced melatonin release along with vitamin B 6 to support melatonin metabolism.

The Sleep Regulator
Supplementation with melatonin is known to reduce sleep latency, or the time required to fall asleep. In addition, some people report improvement in feelings of sleep quality when taking melatonin. Under normal circumstances consuming melatonin 30-90 minutes before bedtime advances sleep phase and promotes sleep.

But melatonin may also prove useful for occasional sleep difficulties secondary to other causes related to mood, mental-health, age, and hospitalization. In fact melatonin is one of the few dietary supplement ingredients that has been researched with some rigor in children experiencing sleep difficulties, including those experienced as side effects of attention-hyperactivity stimulant medication.

An Electromagnetic Transducer?
Anybody that has experienced jet-lag once too often or who has had to work 3rd shift for an extended period of time is probably familiar with the effects of light on sleep patterns and the relevant, researched benefits involved in adjusting the sleep phase with melatonin. But less well-known is the potentially effects caused by night-time illumination. Since melatonin levels are tied to the amount of light sensed by the retina, high-intensity light after sunset can impact melatonin levels. Even low level light during our sleep periods can also affect our melatonin production.

Melatonin Biochemistry
Melatonin is produced biosynthetically from tryptophan and is one of the reasons that tryptophan can help promote sleep and relaxation. Vitamin B 6 is cofactor in this enzymatic pathway, including the process of tryptophan decarboxylation. Although melatonin is synthesized in the pineal gland, a small endocrine gland shaped like a pine-cone that is found between the hemispheres above the brain- stem in vertebrates, it is also produced in the retina, bone-marrow, gall bladder, and gastrointestinal tract.

Melatonin possesses significant direct antioxidant activity scavenging hydroxyl, peroxyl, singlet oxygen, and nitric oxide species. Yet it also stimulates the body’s own antioxidant and Phase I protection systems.

Melatonin’s cyclic changes track and impact other physiological cycles, such as cortisol levels and body temperature. Body temperature seems to be modulated by direct action on the hypothalamus. Action on the hypothalamus is also implicated in effects on the cardiovascular system and blood pressure seen with melatonin. Melatonin is also intimately involved with the immune response, inflammatory cascades, and the health of the intestinal tract.

Melatonin Sustain provides melatonin and a key cofactor (vitamin B 6 ) essential for the biosynthesis of melatonin. Due to an extremely short half-life in blood, melatonin that is released over time in the intestines supports sustained melatonin levels and helps avoid melatonin spikes.

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brand :
Jarrow Formulas
best before:
June 2022
  • time-released
  • tablets
audience :
  • travellers
  • vegan
  • hypo-allergenic
quantity discount:
  • any 2+ = -2.5%!
  • any 3+ = -5%!
  • any 4+ = -7.5%!
  • any 5+ = -10%!
  • any 6+ = -12.5%!
  • any 7+ = -15%!
  • limited availability
shipping costs:
  • €3,75+ (NL) - €7,50+ (EU) - €20+ (world)
  • free shipping >€30 (NL) or €5 discount >€30 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

Hearing problems and COVID-19: tinnitus explained

Among people suffering from what is called 'long-COVID' a new ailment sprang up, tinnitus. Not one that is commonly reported, but it came to the headlines recently when a the founder of a restaurant chain committed suicide after suffering from severe tinnitus as a result of COVID-infection.
While tinnitus is not a symptom you'd expect from a virus, tinnitus is much more common than you'd expect as you rarely hear people complain about it. 
Turns out, there's not much known about tinnitus. You'd expect it is the same as for hearing loss after exposure to excessive noise from work, hobby or a singular event like a very loud concert, fireworks or explosions. While true, that's not the only reason why people contract tinnitus. 
Let's start with the relation between tinnitus and the virus. 

Hearing problems and COVID-19


Influence of the moon on our behaviour

For the longest time, people have felt the influence of the (full) moon on their behaviour.
Especially on cloudless nights, many of us feel an urge to go outside and enjoy watching the full moon. Some will even go so far that they will go on a nightly hike or bike ride.
If this urge still persists today, how influential must the moon it have been in the past when we only could rely on light of the sun, moon and fire?

This is why so many people believe how lunar cycles can and do influence many other aspects of our behaviour and health.
The most persistent one is about its influence on menstruation cycles, fertility and even on the gender of babies. It's not too difficult to understand where this belief comes from: after all, a lunar cycle is almost as long as the average menstruation cycle.

However, until recently, scientists haven't been able to confirm most of the claims.
Only a short while ago it was confirmed how indeed, the full moon does have an impact on the length of our sleep. Even those who live in an urbanized environment, feel the effect of the full moon on their sleep cycle, even though it is far less pronounced than for indigenous people living without artificial light.

About time to explore whether the moon cycle really affects other aspects of our health and/or behaviour.

Can you ever get used to working night shifts?

Last Sunday the Daylight Saving Time ended, and if your reaction was similar to mine, it felt like we plunged right into the darkest time of year. Only a few days earlier, I'd be out and about in broad daylight to get your parcels delivered to you on time, then all of a sudden dusk had set in already.
Maybe your reaction was similar, or if you are someone who rises early, you're happy to see the sun back for a short while when waking up.

Or, perhaps you aren't seeing the sun much at all, because you belong to the almost 20% of people who habitually work at weird hours. Some of you may only work night shifts, while others will have rotating shifts.

For those of you, who may for one reason or another will have to work in shifts soon, we have gathered more background information on how shift work affects your life and how to adapt to it.
Almost everyone has hard time adapting to night shifts, but most people can adapt to it within a few months.

DHEA, what is it and why is it so popular?

DHEA is an abbreviation for dehydroepiandrosterone, which is a steroid hormone available in dietary supplement form. Inside the body, it is made in the adrenal glands.

In the body, DHEA is converted into male and female sex hormones, such as estrogen and testosterone.
DHEA is also responsible for developing “androgenic effects” that are referred to as masculinization. Examples of such changes include production of oilier skin, changes in body odor and growth of armpit and pubic hair.

On the other hand, DHEA can play a part in physiological pathways, since it is believed to bind to certain receptor types and act as a neurosteroid that directly affects neuronal excitability.

DHEA production peaks around age 25. Afterwards DHEA levels decline steadily.

Misconceptions about drug abuse

"Did you hear the news already? Rich Piana died last week!" exclaimed a good friend of ours. "Rich who??" was my response. Then it dawned on me he was speaking of the same person about whom I had been reading the other day and of which I only remembered his face and enormous physique.
Rich Piana, who had a large group of followers on Youtube and Instagram, as he had a most bizarre amount of muscles and was famous for his grueling workouts. 
Almost immediately everyone assumed he probably died due to overuse of steroids and associated muscle-building products.
It is not so weird to assume this as the amount of bodybuilders, who haven't lived past 50 years is staggering, because of the ever more dangerous means of attaining a muscular physique that is bigger than that of other competitors in bodybuilding demand more lives every decade.
The burning desire to create even more muscle mass wins from common sense. When discussing his death people referred a very good documentary called:Bigger, Stronger and Faster. Yet, at a lower level, the sports of recreational bodybuilders, apparently is one of the safest sports around.

How to deal with sleeplessness

Sleep problems are as old as mankind, but it has become more problematic than ever with the advent of modern technology resulting in "poor sleep hygiene". Exposure to bright light late at night results in falling asleep too late and sleeping too little, because it disturbs the body clock that is regulated by melatonin.

recommended use
take 1 or 1/2 tablet 20 to 30 minutes prior to bedtime or as directed by your qualified health care consultant.

contains per daily serving (1 tablet/capsule/lozenge)
vitamin B6 (as pyridoxine HCl) 2mg 100% RDI
melatonin 1mg †

RDI = Recommended Daily Intake
† = RDI not established

active ingredients (pyridoxine HCl, melatonin), filler (cellulose , glycerol behenate, calcium phosphate, stearic acid and magnesium stearate from vegetable source), food grade coating

store in a cool, dry place
keep out of reach of young children

warning and contra-indication
warning: Do not drive or operate machinery immediately following use of this product.
If you have a medical condition (especially asthma, MS, lymphoma, leukemia, diabetes, epilepsy, or autoimmune disease), are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially MAO inhibitors such as iproniazid), consult your health care practitioner before using this product

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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