Maxi-Boz II 90 capsules - Boswellia serrata, a herb with remarkable anti-inflammatory properties | AOR

Maxi-Boz II  90 capsules - Boswellia serrata, a herb with remarkable anti-inflammatory properties | AOR

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brand:Advanced Orthomolecular Research
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AOR Maxi•Boz II is standardized Boswellia serrata extract, a botanical with a long historical usage in traditional Ayurvedic medicine for support in inflammatory conditions. Boswellic acids are the key triterpene phytonutrients which are responsible for Boswellia's ability to help relieve inflammation and support good joint health.

Put Out the Fires
Boswellia functions in a similar way as non-steroidal anti-inflammatory drugs that are generally used in inflammatory conditions. However, boswellic acids are less toxic and even more potent. They are effective at blocking the production of pro-inflammatory signaling molecules which cause the constriction of airways in the lungs. One of these signaling molecules is elastase, which may be involved in emphysema and possibly in cystic fibrosis, chronic bronchitis and acute respiratory distress syndrome. Boswellic acids also block the recruitment of inflammatory cells, and the increased permeability of blood vessels, which allow inflammatory cells to reach tissues. Boswellic acids also specifically inhibit the enzyme that is responsible for producing a main category of pro-inflammatory molecules.

Anti-inflammatory Protection
Maxi Boz II contains standardized Boswellia serrata to prevent and alleviate the damages caused by excessive inflammation and reduce the symptoms of inflammatory disorders such as arthritis, ulcerative colitis, and many others

who can benefit from Maxi-Boz?
People who suffer from the disorders that Boswellia may relieve

key benefits of Maxi-Boz
• can be beneficial for asthma
• can be beneficial for skin disorders
• can be beneficial for inflammatory bowel disease
• is an anti-inflammatory supplement

Boswellia serrata is a branching tree generally found in dry, hilly areas of India

background reading
Anti-inflammatory Activity
Ethanolic extracts of the resin demonstrated reduced carrageenan-induced paw edema in normal rats and mice as well as in adrenalectomized rats. Further, extracts showed anti-arthritic activity in formaldehyde and adjuvant-induced arthritis in rats and BSA-induced arthritis in the rabbit. In addition, the researchers found the above extract to be more beneficial, less toxic and more potent than the standard drug of choice, Ketoprofen, a widely used prescriptive Non-steroidal Anti-inflammatory drug (NSAID). More recently, a number of researchers have identified the anti-inflammatory activity of the ethanolic extracts of the resin to be due to Boswellic Acids, in particular the alpha and beta isomers. Recently, a more purified compound standardized for 65% Boswellic Acids has shown potent anti-inflammatory and anti-arthritic activity without any of the adverse effects (e.g. gastro-intestinal, CNS and cardiovascular).

A study including 70 patients suffering from osteoarthritis of the knee has demonstrated the positive effects of Boswellic acids in humans. These patients received either 100mg or 250mg of boswellic acid containing extract, or a placebo, daily for 90 days. Patients receiving either dose of boswellic acids demonstrated significant improvements in both pain and functional ability of the knee joint. Even more impressive is that patients receiving the 250mg dose showed these improvements as early as 7 days following the start of treatment and required other pain medication 72% less often than patients taking placebos.

The mechanism of action of Boswellic Acids is similar to the action of NSAIDs. Prostaglandins and leukotrienes are two classes of arachidonic acid-derived mediators of inflammation. Leukotrienes, for which 5-lipooxygenase (5-LOx) is the key enzyme in synthesis, are considered to be involved in the initiation and maintenance of various inflammatory diseases, for example arthritis, Crohn's disease, ulcerative colitis, asthma etc. Boswellic Acids are potent inhibitors of 5-lipooxygenase product, including 5-hydroxyeiconatetraenoic acid (5HETE), and leukotriene B4 (LTB4), which cause: bronchoconstriction, chemotaxis, and increased vascular permeability. Other anti-inflammatory plant constituents, such as quercetin, also block this enzyme, but they do so in a more general fashion, as an antioxidant, whereas Boswellia seems to be a specific inhibitor of 5-LOx.

It is known that non-steroidal anti-inflammatory drugs can cause a disruption of glycosaminoglycan (GAG) synthesis that can accelerate the articular damage in arthritic conditions. A recent in-vivo study examined BSE and ketoprofen for their effects on glycosaminoglycan metabolism. BSE significantly reduced the degeneration of GAGs compared to controls, whereas ketoprofen caused a reduction in total tissue GAG content. Boswellic acids have also been shown to decrease the prevalence of matrix metalloproteinases in the synovial fluid. These enzymes are often over expressed in osteoarthritis patients, and have been implicated in the degredation of cartilage in the joints.

In addition, Boswellic Acids inhibited antibody production, as well as infiltration of polymorphonuclear leucocytes, thereby reducing inflammatory effect. In conclusion there is considerable research to support the highly beneficial properties of standardized Boswellic Acids in inflammatory conditions.

Anti-complement Activity
BSE also demonstrated a marked inhibitory effect on both the classical and alternate complement systems.

Analgesic Activity
An investigation of BSE's analgesic and psychopharmacologic effects noted that it "was found to exhibit marked sedative and analgesic effects" in animals.

Inflammatory Bowel Syndrome (IBS)
Leukotrienes are suggested to play a role in the inflammatory process of ulcerative colitis (UC). BSE 350mg three times a day was comparable to sulfasalazine (at 1g three times a day), a standard prescriptive drug in UC.

Other biological activities
BSE has also been observed to inhibit human leukocyte elastase (HLE), which may be involved in the pathogenesis of emphysema. HLE also stimulates mucus secretion and thus may play a role in cystic fibrosis, chronic bronchitis, and acute respiratory distress syndrome.

code GTIN:
0624917042450
code MPN:
AOR04245
brand :
Advanced Orthomolecular Research
best before:
Feb 2024
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  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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The true danger of COVID-19 vaccines : why we should avoid leaky vaccines

Two weeks ago I wrote in my blog on how I did not want a vaccine out of madness because governments won't allow the use of HCQ or ivermectin, both of which are both safe and cheap treatments against COVID-19.
However, I said to not see anything wrong in the vaccine itself. By now I've changed my mind. No, I don't actually deem mRNA vaccines to be unsafe, nor am I too worried about the very rare side-effects of clotting.

What truly spooked me is the fact these are 'leaky' vaccines, which allows viruses to still infect people despite being vaccinated. They just won't get sick, but can become hosts of viruses that may still infect unvaccinated people. Who , in the end no longer will have any other choice but to get vaccinated when a virus has mutated into a too dangerous variant.

At least this is the theory from dr Geert Vanden Bossche, a prominent virologist who spoke out against massive vaccination.

Why is the fact those vaccines are leaky so scary? Let me explain with an article on Marek's disease in chickens.

Should I get the vaccin against COVID-19 or not? On vaccines, ivermectin, paracetamol and fever 

By late April most older adults in the Netherlands will have received an invitation from the government or their physicians to get vaccinated. My own invitation came in this past week, quite a bit earlier than expected. 
 
To be honest, it took me much longer to decide than anticipated. And no, it wasn't just because of all the health scares around the AstraZeneca vaccin due to rare thrombosis incidences. 
 
In general, I'm a fan of vaccinations. As a child I received all of the vaccins that were given to us, with no questions asked.
When travelling to Brazil in 2002, I also followed the guidelines to get vaccinated against yellow fever and hepatitis B. 
 
Like most people, I've also been in awe about the speed at which vaccines were developed for COVID-19. Unlike some, I'm also not as concerned about the use of new mRNA technology to develop the Moderna and Pfizer vaccins. What does appal me though is the high cost for these vaccins, that run in to almost €20 for those high tech vaccins as opposed to just about €2 for a traditional vaccin like Oxford AstraZeneca.
What's worse is that those vaccins don't even offer absolute protection and people may be reinfected with a newer virus strain. Or they may require yearly booster vaccins. 
 
As I was pondering whether or not to get vaccinated, a Youtube video passed by in which dr. John Campbell interviewed dr. Pierre Kory. 
 

Forget about exercising to lose weight: you can't outrun a bad diet! 

A few days ago, an article showed up in my newsfood about a remarkable result of research done on the Hadza tribe in Tanzania, which still leads a traditional hunter-gatherer lifestyle. 
Despite walking an average of a multiple of ten thousands of steps every day, they barely need more calories than the average couch potato in a Western country. 
That same day I discussed with an old friend who had read the same news story. He told me how he had trained for a marathon in the past, but barely dropped any weight while doing so. Only when he spent a week on liquid foods at a spa, he succeeded in losing weight which he mostly thanks to the relaxed environment. Otherwise it was next to impossible. Apparently his body really clung to its precious body fat! 
 
But how was this possible? We didn't really know though we had our suspicions. I I could tell much about the same story. Yes, I'd drop weight pretty fast in the first few weeks of the cycling season or on a longer cycling holiday, but would get stuck at my regular (still too heavy) summer weight while I wasn't really inhaling tons of food. Except then for the Route des Cent Cols during which I could barely eat enough to stay fit and sleep well for all those mountains. 
 
Let's find out more about this particular research!
 
When Herman Pontzer set off for the rugged savannah of Tanzania to spend a summer with the local Hadza people, he thought he knew what he would find. As an evolutionary biologist, his aim was to measure how the Hadza’s hunter-gatherer lifestyle causes them to burn more energy. Because we all know the more exercise you do, the more calories you burn and the slimmer you become, right? Well no, not exactly.
Don’t expect any meaningful weight change in the long term from exercise alone.”
 
What Pontzer and his fellow researchers discovered flew in the face of received wisdom about how our metabolism works. Although the Hadza lead far more active lives than ours – routinely walking long distances, they undertake more physical activity daily than the typical American does in a week – their energy expenditure was no greater. They were burning the same number of calories as men and women from industrialised populations. Our bodies, concluded Pontzer, seem to maintain daily energy expenditure within a narrow window, no matter what lifestyle we lead. While obesity is largely caused by overconsumption, it appears there’s little we can do to change the calories we burn.
 

What's the relation between histamine and gluten intolerance?

A short while ago, I was alerted to research that is being conducted on histamine intolerance. The reason it piqued my interest was the remark on how perceived gluten intolerance may in reality be a case of histamine intolerance. The researchers that were interviewed spoke about probiotics being developed to 'cure' histamine intolerance.

Therefore, without further ado, an explanation on what histamine intolerance really is.

What is histamine?

Histamine is an extremely important bioactive chemical that is indispensable in the efficient functioning of many body systems. It is a neurotransmitter and is involved in the regulation of stomach acid, the permeability of blood vessels, muscle contraction, and brain function.
In humans, the highest histamine concentrations are found in the skin, lung, and stomach, with smaller amounts in the brain and heart.

Histamine is also essential in defending the body against invasion by potentially disease-causing agents such as bacteria, viruses and other foreign bodies.

Histamine is made and stored within white blood cells such as mast cells.
When the immune system is activated in response to foreign material entering the body, histamine is the first "defense chemical", or more correctly, inflammatory mediator released in the process called inflammation. Inflammation is the clinical evidence that the immune system is responding to a potential threat to the body. Histamine is always present when inflammation occurs, and excess histamine will result in symptoms that resemble inflammation.

In addition to its role in controlling vital body processes and defending against foreign invaders, histamine is a key mediator in the symptoms of an allergic reaction. Since allergy is essentially an inflammatory reaction, histamine, together with other protective inflammatory mediators is released in response to the allergen.
Allergens are components of living cells that in themselves are harmless, such as plant pollens, animal dander, mould spores, dust particles, dust mites, and foods. An allergic reaction to these "foreign but harmless" substances occurs when the immune system mistakes these innocuous materials for a potential threat.

Plastics in our body

Only fairly recently we have become aware of the dangers of plastics in our environment.
For a long time we thought these plastics would not be of any concern to us. However, invariably, most plastics end up somewhere in the environment: they sit at the bottom of the sea, mix into beach sand, and blow in the wind. They’re also inside us.

It's possible that humans may be consuming anywhere from 39 to 52 thousand microplastic particles a year. With added estimates of how much microplastic might be inhaled, that number is more than 74 thousand.
People who drink only bottled water ingest an additional 90 thousand particles.

When researchers from Johns Hopkins looked at the impact of eating seafood contaminated with microplastics, they too found the accumulated plastic could damage the immune system and upset a gut's balance.

Scientists are scrambling to understand the dose at which microplastics start to have noticeable health effects. Like air pollution or harmful construction materials, those who have more exposure or pre-existing conditions may be less able to tolerate plastic.

Zinc and HCQ

In the past few months, nearly everyone will have become familiar with the malaria drug hydroxychloroquine (HCQ) and how it has been welcomed as a miracle drug, only to be set aside as being too dangerous to expose sick patients with underlying cardiovascular diseases to it.

Upon learning how HCQ is supposed to be used in this crisis, I was flabbergasted to read how HCQ was put to use by itself, as a drug on its own. True enough, HCQ is a malaria drug, but it was not just meant to be used as a curative medicin on its own for COVID-19 but as a messenger to transport the true miracle mineral, zinc into cells.
The now famous Zelenko protocol which uses HCQ , azithromycin and zinc as well as a number of other essential vitamins and minerals, was never meant to be used in hospital either, but for use by doctors on patients who had just fallen ill.

Now the researchers who discredited HCQ in the Lancet article have been debunked as having used fraudulous data in order to promote a much more expensive drug in which one of the authors had a vested interested, we think it is about time to explain a thing or two on why and how HCQ is used in combination with zinc.

How can allergies be avoided in children?

Children who are exposed to more allergens and bacteria in their homes during the first year of life may be less likely to suffer from allergies, wheezing and asthma later on.

Researchers found that 3-year-olds who were exposed to mouse dander, cat dander and cockroach droppings before they turned 1 were three times less likely to suffer from wheezing, allergies and asthma than those who lived in homes without these allergens.

recommended use
take 1 capsule or as recommended with meals or as recommended by your qualified health care consultant

contains per daily serving (1 capsule)
Boswellia serrata extract (boswellic acids 40%) 333 mg†

† = Recommended Daily Intake not established

ingredients
active ingredients (Boswellia serrata extract), filler (potato starch, microcrystalline cellulose) , capsule (hydroxypropylmethylcellulose)

storage
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children

contra-indication
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product.
Some people may experience mild gastrointestinal effects such as diarrhea, abdominal pain/cramps and nausea. Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

vegetarians/vegans
suitable for vegetarians and vegans

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