AOR Peak K2 is menatetrenone (MK-4), a form of vitamin K2 made in the body from phylloquinone (vitamin K1) and distinct from the menaquinones made by probiotic bacteria. Available science indicates that vitamin K2 - and especially menatetrenone - is superior to Vitamin K1 in maintaining the health of the bones and vascular system. Clinical trials have proven that high-dose vitamin K2 does not cause excessive or abnormal blood clotting, although it will interfere with "blood thinning" medications
key benefits of Peak K2?
• bone health
• brain health
• cardiovascular function
Vitamin K is an essential component for health and deficiency can cause serious consequences in cardiovascular, bone and liver health. Even though vitamin K has been known since the early part of the last century, researchers and clinicians have only focused on its coagulation ability and there has been misunderstanding regarding its safety.
Vitamin K constitutes a family of compounds that exist as natural vitamin K1 (phylloquinone) and vitamin K2 (menaquinones) and the synthetic form vitamin K3 (menadionione). The chemical structure consist of a benzene ring (napthoquinone) and a side chain with various number of isopreny groups. The suffix numbers 4,7,8 and 9 refer to the position of these groups.
Vitamin K1 is the more prevalent form in our diet and is found in leafy green vegetables (lettuce, broccoli, cabbage, spinach etc) and vegetable oils. Vitamin K2 constitutes a family of compounds that include MK-4 and MK-7 forms that are rich in fermented foods like natto and various cheeses and the lesser available forms MK-8 and MK-9. Recent studies have suggested that vitamin K2 is better absorbed and persists longer in the plasma then vitamin K1 and may be more appropriate for supplementation.
The chief function of vitamin K is to act as a co-factor (an adjunct) for vitamin K-dependent proteins in the body and convert the glutamate residues of these proteins into gamma-carboxyglutamate group via an enzymatic process of carboxylation. Such proteins include coagulation factors (II,IV,VI and C), bone turnover molecules (osteocalcin and protein S), vascular repair proteins (Matrix GLA) and proteins responsible for cell-cycle arrest, signal transduction and cell-cell adhesion. The latter three proteins have implications in aberrant growth of cells e.g. tumorigenesis.
1. Bone Health
Bone is a living tissue that continually undergoes remodeling via synthesis and degradation of bone tissue by osteoblast and osteoclast cells respectively. In addition to other key nutrients for proper bone-remodeling e.g. calcium, vitamin D, vitamin C, zinc, magnesium and manganese, vitamin K plasma status is important for maintaining healthy bone. Osteocalcin is a small protein and the degree of its carboxylation (hence vitamin K status) is a measure of bone health. There is a direct correlation between carboxylation of osteocalcin and bone health. In human studies low serum vitamin K levels have been associated with increased incidence of osteopenia (pre-osteoporotic condition) and the full blown osteoporosis. Japanese studies have shown that in areas where there is high consumption of natto (Eastern Japan- Tokoyo) the incidence of osteoporosis and hip fractures is significantly low compared to Western Japan (Hiroshima) where the incidence of natto consumtion is low (hence low vitamin K levels).
2. Vascular Health
Arterial calcification shares many similarities with bone metabolism. Matrix GLA protein is found in vascular tissue. Under carboxylation of this protein (much like osteocalcin) is an indication of low plasma K levels and consequently the arterial tissue is less elastic due to increased calcium deposition resulting in increased incidence of cardiovascular mortality and ischemic heart disease. Studies have shown that vitamin K intake can have a protective effect and prevents loss of elasticity, a key indicator of vascular health. Furthermore, there is a recent clinical study from the UK which shows that vitamin K may protect not only against warfarin induced calcification but also may stabilize and help control anti coagulation levels. However, it is strongly advised that patients taking blood thinning medication like warfarin (Coumadin) should consult their physicians before taking vitamin K2.
3. Hepatocellular carcinoma
Studies have suggested that high levels of vitamin K intake may be associated with a lower incidence of one particular type of liver cancer (hepatocellular carcinoma). The mechanism is postulated to be an effect on inhibiting the cell-cycle, cell-cell adhesions (and possibly the ability to metastasize).
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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Vitamin K and heart healthExperts are recommending that people do what they can to boost their immune systems to work on their immunity and strengthen their defense mechanisms to better combat infection and spread of this virus.
According to a recent study conducted in partnership with the Cardiovascular Research Institute Maastricht, foods rich in vitamin K have been helpful in the battle, and a deficiency may worsen the symptoms of COVID-19.
This virus is known to cause degradation of elastic fibers in the lungs as well as blood clots, vitamin K has been shown to be helpful in the production of proteins that regulate clotting. As such experts have linked the consumption of foods that are rich in vitamin K to blood vessels, bones, and the lungs.
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
Why are multivitamins important for your health?
Sometimes, when your only source of news is from mainstream media, it seems as if taking nutritional supplements is worse than taking medicines. Nothing could be further from the truth.
Especially multivitamins and fish oil can be your cheapest way to top health in addition to a healthy diet. People following healthy diets, are as rare as diamonds and it most certainly doesn't mean following the latest fad diet where you must buy expensive exotic ingredients to be doing it right.
Sadly this is possible when the general public is not being educated properly. Even our national nutritional council (Voedingscentrum) still keeps spouting how you should be consuming artificial margarine instead of real butter as it 'contains extra vitamin D' while butter from grass-fed cows will contain this naturally.
However, there is one truth that is universally embraced by almost everyone: in order to become healthier one has to consumer larger amounts of vegetables and fruits and less heavily processed foods. The sad truth is how most Dutch citizens don't even ingest 200 grams of vegetables and fruit on a given day, a far cry from the recommended 500 grams never mind the optimal 750 grams that is considered to be ideal when you're striving from longevity.
How to prevent or treat varicose veins with natural remedies?Sometimes it seems like varicose veins come out of nowhere when you’re least expecting it. Most people over the age of 60 have some degree, and usually they’re not a big deal. But they could be, it depends on the general health of your veins.
Valves in your veins are supposed to work harmoniously to move blood in one direction, to the heart!
If your heart is weak, or your valves stop working, or your veins lose collagen and become weakened, then the blood stays in your legs and feet longer than it should. It pools faster if you’re standing for a long time or if you’re sitting for a long time like during a long plane flight. The pressure inside your veins makes them wider and after a while, micro amounts of blood leak out into the surrounding tissue.
Varicose veins form, that is what you see when you look at your legs and see those twisted, distended big blue veins. It causes venous insufficiency. You are not the only one suffering: a large amount of especially elderly people and those who have to stand for a long time in their jobs, have varicose veins. They mostly impact the legs and feet.
Why is natto a superfood?When you think of Japanese cuisine, fresh, delicate flavours and intricately presented sushi food come to mind. Amidst all this loveliness, gooey, sticky and stinky fermented soybeans seem somewhat out of place.
Called natto, this stinky dish is lesser known in Europe, but some Japanese (sushi) restaurants offer it as part of their menu and some Asian supermarkets stock it as well.
Natto has a long history as a super food. This little-known Eastern health secret has been a staple in the Japanese diet for more than 1,000 years.
Nutritionally, natto does have a lot to offer. A serving provides the same amount of protein as a similar amount of beef, but with fewer calories.
Natto is a fermented soy food with a distinctive, powerful smell that has been described as similar in pungency to fermented ripe cheese. Or worse, like foot odour mixed with paint thinner.
While some love the taste and will eat it on its own, it's often served with condiments such as sliced green onions, wasabi or pickled ginger.
As a dish it often comes wrapped in rice and seaweed. In Japan, many eat natto at breakfast with rice and, sometimes, with mustard, soy sauce, broth, vegetables or a raw egg.
Natto is a food that divides Japan: half of the Japanese population hates it while the other half likes it.
Natto may not sound that appealing if you aren't a fan of funky flavours, but the growing body of research supporting its health benefits certainly is.
take 1 capsule with meals or as suggeted by your qualified health care consultant
contains per daily serving (1 capsule)
menatetrenone (MK-4) 15mg (12500% RDI)
RDI = Recommended Daily Intake
active ingrediient (menatetrenone), filler (microcrystalline cellulose) , active ingredient (menatetrenone), capsule (hydroxypropylmethylcellulose)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
Clinical trials have documented that menatetrenone does not induce hemostatic activation. However, it will interfere with the activity warfarin (Coumadin®) and possibly other anticoagulant ("blood thinning") medications. Patients prescribed anticoagulants must not take this supplement.
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans