K - Peak K2 90 capsules - menatetrenone MK4 | AOR

K - Peak K2 90 caps - menatetrenone MK4 | AOR

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brand:Advanced Orthomolecular Research
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AOR Peak K2 is menatetrenone (MK-4), a form of vitamin K2 made in the body from phylloquinone (vitamin K1) and distinct from the menaquinones made by probiotic bacteria. Available science indicates that vitamin K2 - and especially menatetrenone - is superior to Vitamin K1 in maintaining the health of the bones and vascular system. Clinical trials have proven that high-dose vitamin K2 does not cause excessive or abnormal blood clotting, although it will interfere with "blood thinning" medications

key benefits of Peak K2?
• bone health
• brain health
• cardiovascular function

background reading
Vitamin K is an essential component for health and deficiency can cause serious consequences in cardiovascular, bone and liver health. Even though vitamin K has been known since the early part of the last century, researchers and clinicians have only focused on its coagulation ability and there has been misunderstanding regarding its safety.


Vitamin K constitutes a family of compounds that exist as natural vitamin K1 (phylloquinone) and vitamin K2 (menaquinones) and the synthetic form vitamin K3 (menadionione). The chemical structure consist of a benzene ring (napthoquinone) and a side chain with various number of isopreny groups. The suffix numbers 4,7,8 and 9 refer to the position of these groups.

Vitamin K1 is the more prevalent form in our diet and is found in leafy green vegetables (lettuce, broccoli, cabbage, spinach etc) and vegetable oils. Vitamin K2 constitutes a family of compounds that include MK-4 and MK-7 forms that are rich in fermented foods like natto and various cheeses and the lesser available forms MK-8 and MK-9. Recent studies have suggested that vitamin K2 is better absorbed and persists longer in the plasma then vitamin K1 and may be more appropriate for supplementation.

Pharmacological functions:
The chief function of vitamin K is to act as a co-factor (an adjunct) for vitamin K-dependent proteins in the body and convert the glutamate residues of these proteins into gamma-carboxyglutamate group via an enzymatic process of carboxylation. Such proteins include coagulation factors (II,IV,VI and C), bone turnover molecules (osteocalcin and protein S), vascular repair proteins (Matrix GLA) and proteins responsible for cell-cycle arrest, signal transduction and cell-cell adhesion. The latter three proteins have implications in aberrant growth of cells e.g. tumorigenesis.

1. Bone Health
Bone is a living tissue that continually undergoes remodeling via synthesis and degradation of bone tissue by osteoblast and osteoclast cells respectively. In addition to other key nutrients for proper bone-remodeling e.g. calcium, vitamin D, vitamin C, zinc, magnesium and manganese, vitamin K plasma status is important for maintaining healthy bone. Osteocalcin is a small protein and the degree of its carboxylation (hence vitamin K status) is a measure of bone health. There is a direct correlation between carboxylation of osteocalcin and bone health. In human studies low serum vitamin K levels have been associated with increased incidence of osteopenia (pre-osteoporotic condition) and the full blown osteoporosis. Japanese studies have shown that in areas where there is high consumption of natto (Eastern Japan- Tokoyo) the incidence of osteoporosis and hip fractures is significantly low compared to Western Japan (Hiroshima) where the incidence of natto consumtion is low (hence low vitamin K levels).

2. Vascular Health
Arterial calcification shares many similarities with bone metabolism. Matrix GLA protein is found in vascular tissue. Under carboxylation of this protein (much like osteocalcin) is an indication of low plasma K levels and consequently the arterial tissue is less elastic due to increased calcium deposition resulting in increased incidence of cardiovascular mortality and ischemic heart disease. Studies have shown that vitamin K intake can have a protective effect and prevents loss of elasticity, a key indicator of vascular health. Furthermore, there is a recent clinical study from the UK which shows that vitamin K may protect not only against warfarin induced calcification but also may stabilize and help control anti coagulation levels. However, it is strongly advised that patients taking blood thinning medication like warfarin (Coumadin) should consult their physicians before taking vitamin K2.

3. Hepatocellular carcinoma
Studies have suggested that high levels of vitamin K intake may be associated with a lower incidence of one particular type of liver cancer (hepatocellular carcinoma). The mechanism is postulated to be an effect on inhibiting the cell-cycle, cell-cell adhesions (and possibly the ability to metastasize).

code MPN:
AOR08007
brand :
Advanced Orthomolecular Research
best before:
March 2022
appearance:
  • v-capsules
audience :
  • senior
  • adults
diet:
  • vegan
  • hypo-allergenic
details:
  • 12+ items = -25%
quantity discount:
  • any 2+ = -5%! (iDEAL/Bancontact/bank)
  • any 3+ = -7.5%!
  • any 4+ = -10%!
  • any 5+ = -12.5%!
  • any 6+ = -15%!
  • any 8+ = -20%!
  • any 12+ = -25%!
availability:
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information:
  • quantity discount is valid for any combination of products
  • free shipping >€30 (NL) or €5 discount >€30 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

Why are multivitamins important for your health?

Sometimes, when your only source of news is from mainstream media, it seems as if taking nutritional supplements is worse than taking medicines. Nothing could be further from the truth.
Especially multivitamins and fish oil can be your cheapest way to top health in addition to a healthy diet. People following healthy diets, are as rare as diamonds and it most certainly doesn't mean following the latest fad diet where you must buy expensive exotic ingredients to be doing it right.

Sadly this is possible when the general public is not being educated properly. Even our national nutritional council (Voedingscentrum) still keeps spouting how you should be consuming artificial margarine instead of real butter as it 'contains extra vitamin D' while butter from grass-fed cows will contain this naturally.

However, there is one truth that is universally embraced by almost everyone: in order to become healthier one has to consumer larger amounts of vegetables and fruits and less heavily processed foods. The sad truth is how most Dutch citizens don't even ingest 200 grams of vegetables and fruit on a given day, a far cry from the recommended 500 grams never mind the optimal 750 grams that is considered to be ideal when you're striving from longevity.

How to prevent or treat varicose veins with natural remedies?

Sometimes it seems like varicose veins come out of nowhere when you’re least expecting it. Most people over the age of 60 have some degree, and usually they’re not a big deal. But they could be, it depends on the general health of your veins.

Valves in your veins are supposed to work harmoniously to move blood in one direction, to the heart!
If your heart is weak, or your valves stop working, or your veins lose collagen and become weakened, then the blood stays in your legs and feet longer than it should. It pools faster if you’re standing for a long time or if you’re sitting for a long time like during a long plane flight. The pressure inside your veins makes them wider and after a while, micro amounts of blood leak out into the surrounding tissue.
Varicose veins form, that is what you see when you look at your legs and see those twisted, distended big blue veins. It causes venous insufficiency. You are not the only one suffering: a large amount of especially elderly people and those who have to stand for a long time in their jobs, have varicose veins. They mostly impact the legs and feet.

Why is natto a superfood?

When you think of Japanese cuisine, fresh, delicate flavours and intricately presented sushi food come to mind. Amidst all this loveliness, gooey, sticky and stinky fermented soybeans seem somewhat out of place.
Called natto, this stinky dish is lesser known in Europe, but some Japanese (sushi) restaurants offer it as part of their menu and some Asian supermarkets stock it as well.

Natto has a long history as a super food. This little-known Eastern health secret has been a staple in the Japanese diet for more than 1,000 years.
Nutritionally, natto does have a lot to offer. A serving provides the same amount of protein as a similar amount of beef, but with fewer calories.

Natto is a fermented soy food with a distinctive, powerful smell that has been described as similar in pungency to fermented ripe cheese. Or worse, like foot odour mixed with paint thinner.
While some love the taste and will eat it on its own, it's often served with condiments such as sliced green onions, wasabi or pickled ginger.
As a dish it often comes wrapped in rice and seaweed. In Japan, many eat natto at breakfast with rice and, sometimes, with mustard, soy sauce, broth, vegetables or a raw egg.

Natto is a food that divides Japan: half of the Japanese population hates it while the other half likes it.
Natto may not sound that appealing if you aren't a fan of funky flavours, but the growing body of research supporting its health benefits certainly is.

Vitamin K or the forgotten vitamin

Vitamin K is often called "the forgotten vitamin" as most will know the function from other vitamins and don't know too much on what role vitamin K plays for our health and as consequence forget to supplement with it.

recommended use
take 1 capsule with meals or as suggeted by your qualified health care consultant

contains per daily serving (1 capsule)
menatetrenone (MK-4) 15mg (12500% RDI)

RDI = Recommended Daily Intake

ingredients
active ingrediient (menatetrenone), filler (microcrystalline cellulose) , active ingredient (menatetrenone), capsule (hydroxypropylmethylcellulose)

storage
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children

contra-indication
Clinical trials have documented that menatetrenone does not induce hemostatic activation. However, it will interfere with the activity warfarin (Coumadin®) and possibly other anticoagulant ("blood thinning") medications. Patients prescribed anticoagulants must not take this supplement.
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product.

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

vegetarians/vegans
suitable for vegetarians and vegans

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