Jarro-Dophilus Mood 10 Billion 30 capsules - digestive probiotic with GABA | Jarrow Formulas
Jarro-Dophilus Mood contains documented probiotic strains plus clinically tested, natural PharmaGABA® in a unique formula that supports the Gut-Brain Axis, promotes mood balance, and reduces the digestive discomfort associated with occasional stress.
GABA is a neurotransmitter that helps balance mood, improves adaptability to stress and supports relaxation and calmness. GABA occurs naturally in various foods.
The Gut-Brain Axis is a bidirectional communication “highway” between the brain and digestive tract that can influence mood.
Coated with EnteroGuard®, a proprietary food-grade, pH-sensitive enteric coating that resists stomach acid.
Jarro-Dophilus® Mood contains clinically documented probiotic strains, and is an efficacious combination at 10 billion cells per day.
PharmaGABA® is a trademark of Pharma Foods International of Japan.
There is a well-established link between stress, mood disorders, and gastrointestinal (GI) conditions and growing scientific evidence shows a link between the gut microflora and the gut-brain axis, which is a bidirectional communication system that exists between the central nervous system and the GI tract. The GI tract contains an enteric nervous system composed of an interconnected network of neurons. The brain sends signals to the gut and receives visceral information from the gut. Signals from the brain can influence the motor, sensory and secretory activities of the gut and messages from the gut can influence brain activity and behavior. The bidirectional signaling is regulated at neural, hormonal and immunological levels. This complex communication system not only ensures proper maintenance and coordination of the intestinal functions but also permits feedback from the gut that can exert effects on mood and behavior. It has become quite evident in recent years that alterations in gut-brain interactions are associated with gut inflammation, chronic abdominal pain, and stress responses and behavior.
Role of the microbiota
The gut microbiota is known to play an important role in our general well-being by contributing to various metabolic, structural and protective functions of the gut. Research conducted over the past decade has shown that alterations in the gut microbiota alters brain function and behavior patterns. Thus, this emerging microbiota-gut-brain axis suggests that the modulation of the gut microbiota may be a potentially effective strategy to influence activities within the gut-brain axis. Probiotic strains’ ability to support intestinal health and function, and especially maintaining intestinal barrier, is the foundation for potentially impacting the functioning of the brain-gut axis.
Animal studies examples using strains in Jarro-Dophilus® Mood
Strains in Jarro-Dophilus® Mood were evaluated in several animal studies for their ability to modulate brain-gut axis activities. In one study, L. rhamnosus R0011 and L. helveticus R0052 were administered to rats to determine if the strains prevent intestinal abnormalities induced by water avoidance test. The strains displayed the ability to improve intestinal barrier function and prevented intestinal abnormalities when subjected to chronic stress.
In another study, using a maternal separation stress, the same two strains were shown to be effective in reducing stress, in the stressed first-generation rats, but also in the second-generation rats. The strains L. helveticus R0052 and B. longum R0175 anxiolytic-like activity in rats were evaluated using the conditioned defensive burying test. The probiotic strains showed a significant effect on the global stress anxiety score and the effect was comparable to that of diazepam.
Human clinical trials with strain in Jarro-Dophilus® Mood
A double-blind, placebo-controlled, randomized clinical study was conducted on 75 healthy volunteers subject to chronic stress. The severity of stress-induced physiological signs was evaluated by self-assessment, using a 62 items questionnaire. The subjects received 3 billion viable cells per serving of L. helveticus R0052 and B. longum R0175 daily, or a placebo, over a 3-week period. At the end of this period, it was found that two stress-induced gastrointestinal discomforts, nausea/vomiting and abdominal pain, were significantly reduced as compared to placebo.
Bloating/flatulence also tended to diminish. It was concluded from this study, the first to test the effects of a probiotic on some stress-induced symptoms, that specific probiotic strains may provide beneficial effects on gastrointestinal functions for people subjected to chronic stress.
A second double-blind, placebo-controlled, randomized clinical study was performed on 55 healthy stressed subjects. The aim of this 30 days duration study, was to determine the effects of L. helveticus R0052 and B. longum R0175, 3 billion viable cells per serving, on psychological criteria associated with stress. Psychological signs of stress were evaluated, using a range of validated psychological assessment scales for anxiety, depression, stress and coping strategies that are normally used to evaluate anxiolytic drugs.
A 24-hour urinary free cortisol level, a biomarker of stress, was also evaluated. This was an unprecedented trial in the field of probiotics. The probiotic group reported an overall reduction in psychological distress, with an improved ability to cope with the stress of everyday life events.
Furthermore, the results of the self-assessment tests were correlated with a decrease of urinary free cortisol levels in the probiotic treated group.
GABA or Gamma-Aminobutyric Acid is the principal inhibitory amino acid transmitter of the central nervous system and is present in some 25-50% of all neurons.
As an inhibitory neurotransmitter, it plays an important role in regulating the neuronal excitability throughout the nervous system.
It acts by reducing the activity of neurons such as those involved in heightened state of excitability.
When nerve signals fire too quickly and carry anxiety-inducing signals, GABA acts to slow the signals down, reducing overwhelming feelings of anxiety and induce relaxation.
- resists stomach acid
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
- cow's milk
- 12+ items = -25%
- any 2+ = -5%! (iDEAL/Bancontact/bank)
- any 3+ = -7.5%!
- any 4+ = -10%!
- any 5+ = -12.5%!
- any 6+ = -15%!
- any 8+ = -20%!
- any 12+ = -25%!
- in stock
- €30+: €0 (NL) - €2+ (EU)
- quantity discount is valid for any combination of products
- free shipping above €30 (NL) or €5 discount above €30 (EU)
- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
How to reduce stress with ASMROur brain is programmed to stress us. It does that a lot and on just about any subject. Like a lot of behavioral reactions, stress used to be and still is a survival mechanism that our brain used in order to inject alertness when needed. It’s there so we could harness internal resources and spring into action in a matter of seconds when hunted or hunting.
Fortunately for us, we rarely need to spring into action nowadays to avoid a prowling lion. Today, stress is not helpful and is often counter-productive. When stressed, most of us lose focus and are immersed in unpleasant feelings.
In the past, we needed all that “potential energy” when we faced fight or flight situations. It probably saved our lives more than once. Today, this energy still exists in each of us in certain situations; if it is not discharged via some sort of conduit (either physical or of a more neural nature), it slows us down.
That’s why we need to get creative in the way we release stress. We don’t have time to go on a vacation every week; often we even can’t step away from the almighty computer, tablet, or cell phone.
Can artificial sweeteners harm gut health and make you gain weight?Early September we published an overview of various natural and artificial sweeteners that are currently available and possible avantages or disadvantages associated to them.
Until very recently the clear-cut explanation of all official governmental dietary agencies as well as most mainstream dieticians was that artificial sweeteners are harmless and not a single iota of proof was available to the contrary.
Even your humble writer still believed sweeteners are relatively harmless as by definition, rats and mice aren't human so evidence about harmfulness for those laboratory animals doesn't prove too much.
However, over time more and more evidence has come up that artificial sweeteners are truly not as good for your waistline as you think they are, in ways that wasn't looked at before. Our gut microbes, which have a bigger influence on your weight and insulin sensitivity than we realize, are negatively inflenced by the artificial sweeteners we ingest.
A healthy gut, a healthy brain
Few people realize how the amount of microbes residing in our gut between the mouth and the end of the large intestine outnumber the amount of human eukaryotic cells by ten to one. This complex ecosystem is formed mainly by bacteria, but also viruses, archae, protozoa and fungi.
Even less known is how gut microbes lays a major role in host health by shaping the development of the immune system, metabolizing dietary nutrients (such as fatty acids, glucose and bile acids) and drugs, digesting complex indigestible polysaccharides and synthesizing vitamins and bioactive molecules.
Throughout different life stages, various changes occur in the microbial diversity of humans.
While babies are massively 'inoculated' with microbes from their mother during birth, smaller amounts enter the baby's gut via the bloodstream and placenta.
After birth, the composition of the gut microbes in the infant changes slowly with age, and stays mostly the same until old age.
While the composition of the gut microbes don't change much in a healthy adult, that is not to say that they aren't vulnerable to outside factors, such as lifestyle, use of antibiotics or even vaccinations, and overall health.
However, outside those factors, diet is one of the most important factors for gut health.
A change in a diet, especially by eating more or less fiber can change the composition of the gut microbitics within a few days. When this change is negative, a dysbiosis can result, characterized by an overgrowth of potentially pathogenic organisms.
This change in the delicate balance between 'good' and 'bad' organisms will result in a 'leaky' gut because of a more porous gut lining and cause chronic inflammation, which can even influence our brain because it also affects our central nervous system. So, as incredible as it sounds, an unhealthy diet can cause you to have an unhealthy brain as well.
This makes it easier to understand why an increasing amount of people try to improve gut health.
take 1 capsule per day, preferably on an empty stomach, or as directed by your qualified physician
contains per daily serving (1 capsule)
probiotic bacteria blend (4 strains, 10 billion organisms) †
Lactobacillus helveticus R0052
Lactobacillus rhamnosus R0011
Bifidobacterium longum R0175
Bifidobacterium longum BB536
Gamma-amminobutyric Acid (PharmaGABA) 100mg †
† = Recommended Daily Intake not established
active ingredients (probiotics with 4 different lactobacillus and bifidus cultures, GABA), fillers (tapioca starch as nutrition for bacteria, magnesium stearate from vegetable source), anticoagulant (silicon dioxide), preservative (ascorbic acid), capsule (hydroxypropyl methylcellulose) with pH-sensitive enteric coating (modified cellulose, magnesium silicate, triethyl citrate, sodium alginate and cellulose gum)
Jarro-Dophilus Mood is room temperature stable and does not require refrigeration. Refrigerating is optional and will further extend the shelf-life by safeguarding the product from heat, especially during the hot summer months.
Keep out of reach of young children
contains milk and soy
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, egg, fish/shellfish or mollusks)
contains traces of milk