Fem Jarro-Dophilus Women 10 billion 60 capsules - female probiotic with 4 strains found in the vaginal tract | Jarrow Formulas

Jarro-Dophilus Women 10 billion 60 capsules combines the most prevalent vaginal lactobacilli species and has been clinically shown to be effective at 5 - 10 billion to help restore healthy vaginal flora. 
4 Clinically Documented, Beneficial Lactobacilli Strains From the Vagina

• Lactobacillus crispatus LbV 88
• Lactobacillus jensenii LbV 116
• Lactobacillus gasseri LbV 150N
• Lactobacillus rhamnosus LbV 96

background reading 

When women desire a probiotic specifically designed to match women’s needs, it is important to look beyond probiotics that are intended to address other issues. Simply put, most probiotic formulas calling themselves a “Women’s Formula” are not one.
They are the same strains these companies use in their other probiotic formulas and have no clinical data for women’s vaginal and urinary tract health.

Jarro-Dophilus® Women contains four clinically documented probiotic Lactobacilli strains:
L. crispatus LbV 88,
L. jensenii LbV 116,
L. gasseri LbV 150N and
L. rhamnosus LbV 96 that have been clinically tested and are covered by European and US patents (EP 2,509,610; US Patent 8,846,027).
The strains were originally isolated from the vaginal tracts of healthy women and clinically tested for efficacy in helping to maintain
protective, native vaginal flora.
They are the prevalent and dominant species of lactobacilli found in healthy vaginal microbiota.
This patented product is manufactured in Good Manufacturing Practices (GMP) facilities under strict quality control to ensure potency and
consistency.

Documented Strains Matter®
Clinical trials have examined whether probiotics taken orally can influence vaginal floral balance and urinary tract health and, likewise, whether all probiotics have such benefits. The answer to the first issue is that, yes, an intake of probiotics as an oral supplement
can significantly and beneficially affect the balance of vaginal flora.
The answer to the second is that only certain probiotics can provide this benefit. Direct comparisons have demonstrated that the probiotic species and strains must be carefully selected in order to significantly and beneficially influence vaginal health.

Lactobacilli For Vaginal Health
Lactobacilli are essential for keeping the vaginal flora healthy. Under certain circumstances, normal resident lactobacilli may be lost. Because the intestinal tract functions as a reservoir for vaginal probiotic lactobacilli, oral supplementation of lactobacilli helps to maintain proper vaginal flora and promote urinary tract health.
The normal vaginal milieu of adult women has a pH of 3.8 to 4.4, and this environment is maintained by the vaginal microbiota predominantly consisting of
lactobacilli and of transient and commensal anaerobic and aerobic bacteria and species common with skin and intestinal microbiota. The documented
lactobacilli found in Jarro-Dophilus® Women help acidify the vagina by producing lactic acid, which lowers vaginal pH and H2O2, and together promotes the normal vaginal flora. Diminished lactobacilli, elevated vaginal pH, reduced H2O2, antibiotic use, and a weakened immune systems can cause recurrent microbial imbalance.

In a study in 319 women visiting an adolescent medicine clinic and 2 other clinics, most women’s normal vaginal bacterial residents included
Lactobacillus (L.) crispatus (32%), followed by L. jensenii (23%), L. 1086V (15%), L. gasseri (5%), L. fermentum (0.3%), L. oris(0.3%),
L. reuteri (0.3%), L. ruminis (0.3%), and L. vaginalis (0.3%).
Colonization by L. crispatus or L. jensenii was associated with a lower frequency of vaginal complaints (P < .001) in US American women.
L. crispatus was also the predominant vaginal lactobacillus, followed by L. gasseri , in 49 healthy Japanese mothers and 64 pregnant women who visited a prenatal clinic in Gifu.
In 132 pregnant women at 35-37 weeks of gestation attending Ghent University Hospital, Belgium, L. crispatus was the most frequently isolated Lactobacillus species from the vagina (40% of the subjects were positive), followed by L. jensenii (32%) and L. gasseri (30%).
Out of 200 Austrian women in the late first trimester of pregnancy without clinical signs of vaginal infection, 126 women were found to have a normal vaginal microbiota based on Gram stain. In these women the most frequently occurring species were Lactobacillus crispatus and Lactobacillus gasseri, followed by Lactobacillus jensenii and Lactobacillus rhamnosus.

Thus there is epidemiological evidence that dominance of L. crispatus, L. jensenii, L. gasseri and L. rhamnosus is characteristic of the vaginal microbiota of healthy women.
The vaginal flora lactobacilli are referred to as the Döderlein bacilli, which is the category of the Astarte® strains in Jarro-Dophilus® Women. The Döderlein bacilli are well known to maintain the acidic vaginal milieu to produce H2O2. The lactobacillus strains in Astarte® were isolated from healthy pregnant women in late first trimester of pregnancy.
This combination of lactobacillus strains has been tested in a double-blind randomized trial in 60 subjects. Oral supplementation with these strains resulted in improvement of vaginal lactobacilli microbiota. Similar positive results have been found in other trials.

The Jarro-Dophilus® Women Difference
Jarro-Dophilus® Women provides the clinically tested Astarte® strains which are protected by European Patent 2,509,610 and and U.S. Patent 8,846,027. Astarte® is owned by HSO Health Care GmbH, Vienna, Austria, and licensed in the U.S. to Jarrow Formulas, Inc. Other international patents pending. (Sold worldwide as Astarte.) Oral ingestion of the strains of Astarte® increased lactobacilli and supported measures of vaginal health in clinical trials.