Estro Adapt 60 capsules - broccoli (DIM), hops, calcium glucarate and choline | AOR

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Retail price: 57,00
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brand:Advanced Orthomolecular Research
best before:Nov 2022
diet:vegan, hypo-allergenic
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AOR Estro Adapt promotes healthy and regular menstruation and balances estrogen.

• supports liver health
• promotes detoxification of toxins, carcinogens and excess estrogen
• reduces the risk of abnormal cellular growth related to excess extrogen in breast and cervical tissues
• balances levels of “bad" and “good" estrogens
• promotes healthy and regular menstruation

background reading
Good vs Bad Estrogens
Estrogen has long been considered a risk factor for a variety of women’s cancers, especially breast cancer. In fact, the risk of breast cancer has been shown to increase with the number of premenopausal years, when estrogen levels are highest. Research has shown that natural estrogens can also be classified as “good” or “bad”. For example, 16α-hydroxylated (“bad”)estrogen metabolites have stronger estrogen activity and are associated with an increased risk of breast cancer, while 2-hydroxylated (“good”)estrogen metabolites are weaker and are not associated with increased risk of estrogen positive cancers.

Estro Adapt to the Rescue
Fortunately, there are natural solutions available that can help tip the balance towards the “good” estrogens, and to help detoxify and eliminate “bad” estrogens and xenoestrogens. The ingredients in Estro Adapt work together to promote a healthy estrogen balance and to promote the detoxification of harmful substances, thereby helping to reduce the risk of women’s cancers.

Estrogens are very important hormones. Although they are present in both men and women, their best known role is as the primary female sex hormones, and they are thus involved in the development of female characteristics and in the regulation of the menstrual cycle. Estrogens have over 400 different functions in the body, some of which include the maintenance of tissue strength, cardiovascular health, mood, bone health and vision.

Different Types of Estrogen
There are many different kinds of estrogens, which can be confusing. The general term “estrogen” tends to be used to describe all types of estrogens, including naturally occurring estrogen produced in the body, estrogens produced by plants (phytoestrogens) and environmental estrogens (xenoestrogens). What is important to note is that while some estrogens are healthy and beneficial, other types can have negative effects. The differences between so-called “good” and “bad” estrogens have already been discussed briefly. There are also compounds called xenoestrogens that can have negative biological effects.

For example, xenoestrogens, which are synthetic estrogens encountered in the environment, are particularly dangerous. These compounds can be present in synthetic hormones, pesticides and plastics. They do not react in our body the same way as natural estrogens, and can be difficult to eliminate from the body. Xenoestrogens have been associated with disrupted reproductive processes and an increased risk of cancer.

How do the ingredients in Estro Adapt help?

D-glucarate is a naturally occurring compound that is produced by the body in small amounts and is also found in many fruits and vegetables. D-glucarate plays a very important role in the detoxification of toxins and carcinogens. One very important detoxification pathway in the body is the glucuronidation pathway. Through glucuronidation toxic substances, environmental carcinogens and even excess levels of estrogen are neutralized, and then eliminated from the body.

Unfortunately, this important detoxification process can be disrupted by the enzyme beta-glucuronidase, which acts to reactivate the neutralized toxins. Elevated levels of this enzyme have been associated with an increased incidence of breast, prostate and colon cancers. This is where D-glucarate comes in. The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification.

Research has shown that D-glucarate can inhibit breast cancer development in mice by as much as 70%. Calcium-D-glucarate’s inhibition of beta-glucuronidase also allows the body to excrete estrogen before it is reabsorbed by the body. In this way D-glucarate can help to encourage healthy estrogen metabolism, and prevent elevated estrogen levels. D-glucarate has been shown to lower serum estrogen levels in rats by 23%. Preliminary studies in humans show that D-Glucarate supplements are safe, and have the same effects on beta-glucuronidase in people that they do in animals. Studies on D-glucarate supplements in women at risk for breast cancer are underway, and it has been suggested that D-glucarate may provide a safe, effective and side-effect free alternative to the drug tamoxifen.

3,3’-Diindolymethane (DIM)
DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM has been shown to promote the formation of 2-hydroxylated estrogen metabolites instead of 16α-hydroxylated estrogen metabolites. This means that DIM helps to push the balance of estrogen in the body towards the production of “good” estrogens and reduces the production of “bad” estrogens. In cell culture studies DIM has powerful anti-cancer effects, and has been shown to stop breast and cervical cancer cell growth in vitro. It has also been shown to block the activation of genes that promote cancer cell growth while activating genes that help prevent cancer.

Human studies also show promising results. DIM is currently used to treat Recurring Respiratory Papillomatosis caused by the Human Papilloma Virus and is in Phase III clinical trials for Cervical Dysplasia. Cervical Dysplasia is a precancerous condition also caused by the Human Papilloma Virus, and is highly correlated to the development of cervical cancer. Preliminary open-label testing has shown that treatment with DIM successfully resolved moderate to severe cervical dysplasia.

Sulforaphane is another naturally occurring substance found in the brassica family of vegetables, such as broccoli. Sulforaphane has been shown to stimulate the natural defenses of the body to prevent or improve chronic disease. It is a natural anti-oxidant and a potent inducer of phase II liver detoxification enzymes. The phase II detoxification enzymes are responsible for eliminating harmful toxins and carcinogens from the body. Additionally, research has shown that sulforaphane acts directly to inhibit cancer cell growth and to initiate apoptosis, or death, of cancer cells through a variety of mechanisms.

In regards to women’s health, sulforaphane has been shown to inhibit the proliferation of breast cancer cells, and to reduce their expression of the estrogen receptor, thereby interfering with the ability of estrogen to bind the receptor and initiate cellular proliferation and growth.

Hops Extract – 8-prenylnarigenin
8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen, or plant estrogen. It has been shown to be of equal or greater potency as soy-derived phytoestrogens like genistein. In vitro 8PN has been shown to inhibit breast cancer cell proliferation by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogensis (the formation of new blood vessels to feed tumors) both in test tube and animal studies.

Furthermore, 8PN has benefits for women with menopause. One double blind randomized cross over study (specifically designed to take into account the high degree of "placebo" effect common with menopausal studies) showed that 8PN reduced hot flashes, night sweats and other menopausal symptoms significantly. In animal studies, it has also been shown to help reduce atherosclerosis and reduce cholesterol levels. It has been proposed that 8PN may help to prevent the incidence of cardiovascular disease associated with low estrogen levels. Lifenol®’s hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.

A population-based analysis published in 2008 found that those who consumed the most choline had the lowest risk for breast cancer. Upon finding certain genetic polymorphisms, the authors concluded that choline may reduce cancer cell progression, but the mechanisms are not yet clear.

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brand :
Advanced Orthomolecular Research
best before:
Nov 2022
  • v-capsules
audience :
  • senior
  • women
  • vegan
  • hypo-allergenic
  • 7+ items = -15%
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  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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recommended use
Take 2 capsules daily with breakfast or as recommened by a qualified health practioner.

contains per daily serving (2 capsules)
calcium d-glucarate 150mg
LIFENOL® Hops extract (0.12% 8-prenylnaringenin) 120mg
broccoli extract (300mg) with
- DIM (3,3'-Diindolymethane) 108mg
choline (bitartrate) 27.6mg

active ingredients (broccoli extract with DIM, calcium glucarate, hops extract, choline bitartrate), filler (microcrystalline cellulose, maltodextrin), anticoagulant (silica), veggie-capsule (hypromellose, water)

keep out of reach of young children

Consult a health care practitioner if you are attempting to conceive, taking hormone replacement therapy or birth control pills or other medications, if symptoms persist or worsen, for use beyond 3 weeks, if you have or are predisposed to cancer or a liver disorder, or develop liver-related symptoms (e.g. abdominal pain, jaundice), depression and/or related diseases.
Consumption of Hops with alcohol, other medications and/or natural health products with sedative properties is not recommended.
Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness.
Discontinue use if you experience joint pain or hot flashes. Discontinue use and consult a health care practitioner if you experience irregular menstruation. May temporarily alter urine colour.
Consult a health care practitioner if urine does not normalize upon discontinued use.

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks) or any other animal byproduct.

suitable for vegetarians and vegans

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