D+K - K-Right 60 softgels - K1 + MK-4 + MK-7 + D3, optimized vitamin K-complex | Jarrow Formulas
Jarrow Formulas K-Right ™ is a synergistic combination of three forms of Vitamin K: MK-7, MK-4 and K1, plus vitamin D3 to promote bone and cardiovascular health.
Vitamin K is essential for the carboxylation of osteocalcin, which binds calcium in bones.
Vitamin D3 is essential for the production of osteocalcin.
Jarrow Formulas® MK-7 is a product of natural fermentation using Bacillus subtilis subsp. natto.
- promotes bone and cardiovascular health
- contains 3 forms of vitamin K, including MK-7 which work in synergy
- contains MK-7 (Menaquinone-7), an enhanced bioactive form of vitamin K2 from natto, 10x better absorbed than K1 from spinach
- synergistic vitamin D3 for production of vitamin K-dependent proteins and bone formation
- amount of each vitamin K form per serving clinically shown to individually support bone health
who can benefit from K-Right?
Adolescents up to the elderly seeking to improve and maintain vitamin K and D status in support of bone and cardiovascular health
how does each active ingredient function in K-Right?
vitamin K2 as MK-7 : superior “activation” of vitamin K-dependent proteins in peripheral tissues such as bone and blood vessels vs.
other forms of vitamin K
vitamin K2 as MK-4: unique, non-enzymatic functions among vitamin K forms to compliment traditional functions of vitamins K and D in
support of bone and cardiovascular health
vitamin K1: may be preferentially used by liver to spare vitamin K2 forms for peripheral functions of vitamin K outside the liver.
vitamin D3 : the active form of vitamin D in the body supports production of vitamin K-dependent proteins and bone
vitaMK7® is a registered trademark of Gnosis.
Naturally occurring forms of vitamin K include phylloquinone (vitamin K1) and a family of molecules called menaquinones (vitamin K2). Phylloquinone (K1) is made by plants and algae, and is the predominant form in typical Western diets, whereas menaquinones (K2) are made by bacteria and difficult to obtain meaningful amounts through the diet alone.
Both vitamin K1 and K2 function as an essential cofactor for the enzyme, gamma-glutamyl carboxylase (GGCX), which converts specific protein-bound glutamic acid (Glu) residues to gamma-carboxyglutamic acid (Gla) residues capable of binding calcium ions, a process known as carboxylation.
The carboxylation of calcium-regulating vitamin K-dependent proteins (VKDPs) is needed to convey functional activity in the body (“activate”). VKDPs have well recognized roles in blood coagulation, bone mineralization, and restriction of calcium deposition into soft tissues such as the arteries.
Vitamin D, another fat-soluble vitamin important for bone and cardiovascular health, works synergistically with vitamin K.
The active form of vitamin D in the body, calcitriol, positively regulates the gene expression of VKDPs. Thus, vitamin D supports the production of VKDPs and vitamin K is needed to “activate” those proteins.
Vitamin K2: Menaquinones
All forms of vitamin K are composed of a methylated naphthoquinone ring, the main functional group required for its function as an essential GGCX enzyme cofactor to carboxylate VKDPs. However, they differ in the structure of their side chains. Phylloquinone (K1) contains four isoprenoid residues in its side chain, with only one unsaturated, whereas menaquinones (K2) are comprised of unsaturated isoprenoid residues of varying lengths. The number of isoprenoid residues is indicated in the name of the particular menaquinone, designated menaquinone-n (MK-n), with n representing the number of unsaturated isoprenoid residues in the side chain. For example, menaquinone-7 (MK-7), has 7 isoprenoid residues in its side chain.
Beyond blood clotting: bone & cardiovascular health
Originally identified for its role in blood clot formation (“K” is derived from the German word “koagulation”), vitamin K is now recognized for its role in bone formation and the prevention of soft tissue calcification. A number of VKDPs have been identified in the organic matrix of bone including osteocalcin (OC), the most abundant non-collagen protein in bone. OC is made by boneforming cells (osteoblasts), which is positively regulated by the active form of vitamin D (calcitriol), and is indispensable for bone mineralization. Fully carboxylated OC (cOC) is positioned within bone and binds calcium strongly to consolidate calcification of the hydroxyapatite crystal lattice, but when undercarboxylated (ucOC), the calcium binding capacity of OC is greatly diminished.
Insufficient vitamin K availability impairs OC function and is associated with greater risk of bone fractures, whereas higher vitamin K status is associated with greater bone mineral density in both children and adults, along with reduced fracture risk.
The VKDP, matrix-Gla protein (MGP), operates predominantly in the extracellular matrix of soft tissues (e.g., blood vessels, heart, lungs, cartilage) to restrict calcium deposition. The gene promoter region of MGP has a vitamin D response element and vitamin D3 has been shown to increase MGP gene expression to support its production. MGP likely inhibits blood vessel calcification by binding calcium ions to sequester them and thereby restrict their incorporation into the extracellular matrix that can lead to hardening and compromise function.
MK-7: The Premier Form of Vitamin K
Clinical research has shown that supplementation with the longchain menaquinone, MK-7, results in significantly higher and more stable blood levels of vitamin K (7- to 8-fold), and greater efficacy in carboxylation of VKDPs in both the liver and peripheral tissues compared to vitamin K1.
MK-7 was also shown to be significantly more effective than equivalent dosing of MK-4 at increasing vitamin K levels in circulation and increasing tissue levels of MK-4 significantly better than MK-4 itself.
MK-4: unique, non-enzymatic functions
Because all forms of vitamin K can be converted to MK-4 in the body, MK-4 was thought to have unique functions other than as an essential GGCX cofactor. Indeed, MK-4 has been shown to bind the steroid and xenobiotic receptor (SXR) to increase the expression of genes that support the formation of bone and increased the accumulation of collagen in bone forming cells, whereas other forms of vitamin K do not activate this receptor.
This non-enzymatic function of vitamin K compliments functions of the active form of vitamin D at positively regulating the activity of bone forming cells. Treatment of bone forming cells with both vitamins D3 and K2 (as MK-7) enhanced bone forming activities including collagen production, and MK-7 augmented vitamin D3 induction of osteocalcin.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Can vitamin D help combat infectious diseases like COVID-19?
Vitamin K and heart healthExperts are recommending that people do what they can to boost their immune systems to work on their immunity and strengthen their defense mechanisms to better combat infection and spread of this virus.
According to a recent study conducted in partnership with the Cardiovascular Research Institute Maastricht, foods rich in vitamin K have been helpful in the battle, and a deficiency may worsen the symptoms of COVID-19.
This virus is known to cause degradation of elastic fibers in the lungs as well as blood clots, vitamin K has been shown to be helpful in the production of proteins that regulate clotting. As such experts have linked the consumption of foods that are rich in vitamin K to blood vessels, bones, and the lungs.
Zinc and HCQ
In the past few months, nearly everyone will have become familiar with the malaria drug hydroxychloroquine (HCQ) and how it has been welcomed as a miracle drug, only to be set aside as being too dangerous to expose sick patients with underlying cardiovascular diseases to it.
Upon learning how HCQ is supposed to be used in this crisis, I was flabbergasted to read how HCQ was put to use by itself, as a drug on its own. True enough, HCQ is a malaria drug, but it was not just meant to be used as a curative medicin on its own for COVID-19 but as a messenger to transport the true miracle mineral, zinc into cells.
The now famous Zelenko protocol which uses HCQ , azithromycin and zinc as well as a number of other essential vitamins and minerals, was never meant to be used in hospital either, but for use by doctors on patients who had just fallen ill.
Now the researchers who discredited HCQ in the Lancet article have been debunked as having used fraudulous data in order to promote a much more expensive drug in which one of the authors had a vested interested, we think it is about time to explain a thing or two on why and how HCQ is used in combination with zinc.
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
Why are multivitamins important for your health?
Sometimes, when your only source of news is from mainstream media, it seems as if taking nutritional supplements is worse than taking medicines. Nothing could be further from the truth.
Especially multivitamins and fish oil can be your cheapest way to top health in addition to a healthy diet. People following healthy diets, are as rare as diamonds and it most certainly doesn't mean following the latest fad diet where you must buy expensive exotic ingredients to be doing it right.
Sadly this is possible when the general public is not being educated properly. Even our national nutritional council (Voedingscentrum) still keeps spouting how you should be consuming artificial margarine instead of real butter as it 'contains extra vitamin D' while butter from grass-fed cows will contain this naturally.
However, there is one truth that is universally embraced by almost everyone: in order to become healthier one has to consumer larger amounts of vegetables and fruits and less heavily processed foods. The sad truth is how most Dutch citizens don't even ingest 200 grams of vegetables and fruit on a given day, a far cry from the recommended 500 grams never mind the optimal 750 grams that is considered to be ideal when you're striving from longevity.
How to prevent or treat varicose veins with natural remedies?Sometimes it seems like varicose veins come out of nowhere when you’re least expecting it. Most people over the age of 60 have some degree, and usually they’re not a big deal. But they could be, it depends on the general health of your veins.
Valves in your veins are supposed to work harmoniously to move blood in one direction, to the heart!
If your heart is weak, or your valves stop working, or your veins lose collagen and become weakened, then the blood stays in your legs and feet longer than it should. It pools faster if you’re standing for a long time or if you’re sitting for a long time like during a long plane flight. The pressure inside your veins makes them wider and after a while, micro amounts of blood leak out into the surrounding tissue.
Varicose veins form, that is what you see when you look at your legs and see those twisted, distended big blue veins. It causes venous insufficiency. You are not the only one suffering: a large amount of especially elderly people and those who have to stand for a long time in their jobs, have varicose veins. They mostly impact the legs and feet.
take 1 softgel per day or as directed by your qualified healthcare professional
contains per daily serving (1 softgel)
vitamin D3 (cholecalciferol) 50 mcg / 2000iu (250% RDI)
vitamin K1 (phylloquinon) 500 mcg (420% RDI)
MK-4 (vitamin K2 as menatetrenone or menaquinone-4) 1500 mcg (1250% RDI)
MK-7 (vitamin K2 as menaquinone-7) 180 mcg (150% RDI)
RDI = Recommended Daily Intake
active ingredients (cholecalciferol, phylloquinon, menaquinon), filler (extra virgin olive oil), softgel capsule (bovine gelatin, glycerin, purified water), light barrier (organic caramel)
store in a cool, dry place
keep out of reach of young children
warning and contra-indications
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18 or taking medications (especially anticoagulants such as warfarin/coumadin), consult your healthcare professional before using this product.
contrains traces of soy (from natto)
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)