Curcumin Phytosome 60 capsules - Curcuma longa + phosphatidylcholine | Jarrow Formulas
Jarrow Formulas Curcumin Phytosome 60 capsules supports healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva®, a phytosome form of curcumin, is a patent-pending ingredient consisting of curcumin extract bound to phosphatidylcholine for increased absorption and bioavailability. Clinical studies show that it promotes joint health and flexibility.
Meriva® is a registered trademark of Indena S.p.A.
Turmeric (Curcuma longa) is a bright yellow spice and a traditional remedy that has been used as a medicine, condiment, and flavoring since 600 BC. The rhizome (underground stem) is the part of the plant that is harvested and ground to make the spice. The key bioactive constituents found in turmeric are three kinds of curcuminoids: curcumin, demethoxyl-curcumin, and bisdemethoxyl-curcumin. All three components are structurally similar, although curcumin seems to be the most effective constituent. Curcumin and these related curcuminoids appear to effect human health through antioxidant activity and possible modulation of 5-lipo-oxygenase (LOX) and cyclo-oxygenase (COX) enzymes.
The true health potential of curcumin always has been hindered by notoriously poor oral bioavailability. This has become generally accepted in recent years with numerous studies in humans demonstrating severe absorption shortcomings, even when curcumin is consumed in large quantities. As a result, researchers have sought ways to overcome this limitation of curcumin. One particularly useful strategy employs phospholipids to produce micelles, or curcumin phytosomes, that act as protective curcumin couriers.
The Phytosome Difference
Curcuminoids show a high affinity for biological membranes but are poorly soluble in water. However, when surrounded or “complexed,” with phospholipids such as phosphatidylcholine curcuminoids become dispersible in water. Phospholipids can have this sort of self-emulsifying effect for substances that are otherwise poorly soluble in water and the digestive tract.
But the phytosomes do more than just help overcome the poor water solubility of curcumin. They also appear to directly impact absorption by shuttling the curcuminoids inside enterocytes. This occurs because cellular membranes, including intestinal enterocytes, are largely composed of phospholipids, such as the phosphatidylcholine found in the phytosomes, allowing the phytosomes to act as vesicles that can be “folded” into the cell in a process called pinocytosis or cellular captation. The absorption technology found in Jarrow Formulas’ QH-absorb® works in a similar manner.
But that’s not all. The phytosome also appears to act as a barrier to the hydrolytic and enzymatic degradation known to affect curcuminoids in the digestive tract. As one example, curcuminoids are known to undergo retro-Claisen type reactions in the digestive tract, which converts them into their dihydro- counterparts altering their activity. Another example is glucuronidation reactions known to take place during the digestive process. Phytosomes are thought to be protective here as well.
Evidence of Success
Yet the evidence for the utility of curcumin phytosomes is not merely academic. In a human bioavailability study, healthy volunteers were randomly assigned to three groups and given either 1.0 g of Meriva, 1.9 g of Meriva, or 1.8 of regular curcumin powder. The overall increase of curcuminoid absorption from Meriva was ca. 29-fold (27-fold for the low 1.0 gram group and 31-fold for the 1.9 gram) on a curcuminoid equivalents basis. These results in humans are also corroborated by a pharmacokinetic study conducted with male Wistar rats that yielded comparable absorption increases.
Blood levels aside, the biggest question is do curcumin phytosomes work? In fact, multiple human clinical studies have demonstrated just that. In one study published in 2010, Meriva was given to 25 volunteers experiencing joint discomfort, while another 25 received a placebo. After three months of daily use, the Meriva group scored significantly better on the WOMAC scale (indicating joint comfort) and showed markers indicative of a more balanced inflammatory response. These results would appear to confirm the idea that increased stability and better absorption of curcumin induced by complexation with phospholipids, has clinical relevance.
Jarrow Formulas’ Curcumin Phytosome supports a healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva® is a patent-pending ingredient consisting of curcumin and phosphatidylcholine for increased absorption and bioavailability.
Clinical studies show that it promotes joint health and flexibility.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Are eggs good or bad for diabetes?
Outside COVID-19 very little health news catches the attention of newspapers, unless it is something out of the ordinary.
One such news item was the result from an observational study among Chinese citizens of whom it was reported how those eating more eggs had a higher risk of diabetes 2.
Oh boy, here we go again was my first thought. First eggs were vilified due to their cholesterol content, and now that nonsense has been put to rest [link], they try to come up with another BS research. Yes, calling it BS.
Imagine, you are a notorious smoker and decide to give up smoking because your lungs are suffering and have developed COPD. Yet, it is too late and a lung tumour has been detected. Guess what? The clickbait headlines would go like "people that give up smoking, will develop lung cancer!".
That's how it works! Time and again we have to repeat: correlation is NOT the same as causation. This was an observational study, in which people were asked about their habits.
A much better research method is a clinical study in which people are meticulously followed after treatment.
Or a meta study in which several studies are lumped together and analysed.
Plastics in our bodyOnly fairly recently we have become aware of the dangers of plastics in our environment.
For a long time we thought these plastics would not be of any concern to us. However, invariably, most plastics end up somewhere in the environment: they sit at the bottom of the sea, mix into beach sand, and blow in the wind. They’re also inside us.
It's possible that humans may be consuming anywhere from 39 to 52 thousand microplastic particles a year. With added estimates of how much microplastic might be inhaled, that number is more than 74 thousand.
People who drink only bottled water ingest an additional 90 thousand particles.
When researchers from Johns Hopkins looked at the impact of eating seafood contaminated with microplastics, they too found the accumulated plastic could damage the immune system and upset a gut's balance.
Scientists are scrambling to understand the dose at which microplastics start to have noticeable health effects. Like air pollution or harmful construction materials, those who have more exposure or pre-existing conditions may be less able to tolerate plastic.
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
Why is turmeric such a magical herb?
Recently, it became once again evident how mainstream media is being manipulated by Big Pharma to scare the public away from using well-known and empirically proven supplements towards using pharmaceutical medicine.
One such health scare tactic was aimed towards the use of curcumin, which has become one of the most popular health supplements , among which to support people recovering from breast cancer.
Apparently, one effect of curcumin is that it speeds up detoxification processes in the liver, which results in medicine being broken down more easily.
In this particular health scare, that's an undesirable side-effect because tamoxifen, a frequently used post-treatment drug, is also broken down more rapidly and hence, becomes less effective at lower dosages, when combined with high dosages of curcumin.
While this was touted as proof how dangerous it is to take unproven herbal supplements, this is nothing out of the ordinary. Many other products can speed up the liver detoxification process, with the most famous of them being the mood-enhancing herb St. John's Wort.
However, there are other products that do the contrary, among which grapefruit as well as green tea , which slow down the same detoxification liver enzyme.
Some of you may not be aware yet why both turmeric and curcumin have become such popular condiments as well as food supplements. Therefore we present you a breakdown on what curcumin is about.
Magical turmericTurmeric (Curcuma longa) is a spice grown in India and other in tropical countries in Asia . This spice has been part of religious ceremonies in India for thousands of years. Turmeric is related to ginger with which it shares some of its active ingredients.
Take 1 capsule per day with food.
For enhanced joint protection, take 1 capsule 2 times per day or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
Meriva 500mg †
curcumin phytosome phosphatidylcholine complex (Curcuma longa, rizome with 18-22% curcuminoids)
† = Recommended Daily Intake not established
active ingredient (curcumin phytosome phosphatidylcholine complex), filler (cellulose), anticoagulant (silicon dioxide), filler (magnesium silicate and vegetable magnesium stearate), capsule (hydroxypropylmethylcellulose)
store in a cool, dry place
keep out of reach of young children
contains no familiar allergens (wheat, gluten, soy lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans