Curcumin Phytosome 120 capsules value-size - Curcuma longa + phosphatidylcholine | Jarrow Formulas
Jarrow Formulas Curcumin Phytosome 120 capsules supports healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva®, a phytosome form of curcumin, is a patent-pending ingredient consisting of curcumin extract bound to phosphatidylcholine for increased absorption and bioavailability. Clinical studies show that it promotes joint health and flexibility.
Meriva® is a registered trademark of Indena S.p.A.
Turmeric (Curcuma longa) is a bright yellow spice and a traditional remedy that has been used as a medicine, condiment, and flavoring since 600 BC. The rhizome (underground stem) is the part of the plant that is harvested and ground to make the spice. The key bioactive constituents found in turmeric are three kinds of curcuminoids: curcumin, demethoxyl-curcumin, and bisdemethoxyl-curcumin. All three components are structurally similar, although curcumin seems to be the most effective constituent. Curcumin and these related curcuminoids appear to effect human health through antioxidant activity and possible modulation of 5-lipo-oxygenase (LOX) and cyclo-oxygenase (COX) enzymes.
The true health potential of curcumin always has been hindered by notoriously poor oral bioavailability. This has become generally accepted in recent years with numerous studies in humans demonstrating severe absorption shortcomings, even when curcumin is consumed in large quantities. As a result, researchers have sought ways to overcome this limitation of curcumin. One particularly useful strategy employs phospholipids to produce micelles, or curcumin phytosomes, that act as protective curcumin couriers.
The Phytosome Difference
Curcuminoids show a high affinity for biological membranes but are poorly soluble in water. However, when surrounded or “complexed,” with phospholipids such as phosphatidylcholine curcuminoids become dispersible in water. Phospholipids can have this sort of self-emulsifying effect for substances that are otherwise poorly soluble in water and the digestive tract.
But the phytosomes do more than just help overcome the poor water solubility of curcumin. They also appear to directly impact absorption by shuttling the curcuminoids inside enterocytes. This occurs because cellular membranes, including intestinal enterocytes, are largely composed of phospholipids, such as the phosphatidylcholine found in the phytosomes, allowing the phytosomes to act as vesicles that can be “folded” into the cell in a process called pinocytosis or cellular captation. The absorption technology found in Jarrow Formulas’ QH-absorb® works in a similar manner.
But that’s not all. The phytosome also appears to act as a barrier to the hydrolytic and enzymatic degradation known to affect curcuminoids in the digestive tract. As one example, curcuminoids are known to undergo retro-Claisen type reactions in the digestive tract, which converts them into their dihydro- counterparts altering their activity. Another example is glucuronidation reactions known to take place during the digestive process. Phytosomes are thought to be protective here as well.
Evidence of Success
Yet the evidence for the utility of curcumin phytosomes is not merely academic. In a human bioavailability study, healthy volunteers were randomly assigned to three groups and given either 1.0 g of Meriva, 1.9 g of Meriva, or 1.8 of regular curcumin powder. The overall increase of curcuminoid absorption from Meriva was ca. 29-fold (27-fold for the low 1.0 gram group and 31-fold for the 1.9 gram) on a curcuminoid equivalents basis. These results in humans are also corroborated by a pharmacokinetic study conducted with male Wistar rats that yielded comparable absorption increases.
Blood levels aside, the biggest question is do curcumin phytosomes work? In fact, multiple human clinical studies have demonstrated just that. In one study published in 2010, Meriva was given to 25 volunteers experiencing joint discomfort, while another 25 received a placebo. After three months of daily use, the Meriva group scored significantly better on the WOMAC scale (indicating joint comfort) and showed markers indicative of a more balanced inflammatory response. These results would appear to confirm the idea that increased stability and better absorption of curcumin induced by complexation with phospholipids, has clinical relevance.
Jarrow Formulas’ Curcumin Phytosome supports a healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva® is a patent-pending ingredient consisting of curcumin and phosphatidylcholine for increased absorption and bioavailability.
Clinical studies show that it promotes joint health and flexibility.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Take 1 capsule per day with food.
For enhanced joint protection, take 1 capsule 2 times per day or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
Meriva 500mg †
curcumin phytosome phosphatidylcholine complex (Curcuma longa, rizome with 18-22% curcuminoids)
† = Recommended Daily Intake not established
active ingredient (curcumin phytosome phosphatidylcholine complex), filler (cellulose), anticoagulant (silicon dioxide), filler (magnesium silicate and vegetable magnesium stearate), capsule (hydroxypropylmethylcellulose)
store in a cool, dry place
keep out of reach of young children
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans