Curcumin Phytosome 120 capsules - Curcuma longa + phosphatidylcholine | Jarrow Formulas
Jarrow Formulas Curcumin Phytosome 120 capsules supports healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva®, a phytosome form of curcumin, is a patent-pending ingredient consisting of curcumin extract bound to phosphatidylcholine for increased absorption and bioavailability. Clinical studies show that it promotes joint health and flexibility.
Meriva® is a registered trademark of Indena S.p.A.
Turmeric (Curcuma longa) is a bright yellow spice and a traditional remedy that has been used as a medicine, condiment, and flavoring since 600 BC. The rhizome (underground stem) is the part of the plant that is harvested and ground to make the spice. The key bioactive constituents found in turmeric are three kinds of curcuminoids: curcumin, demethoxyl-curcumin, and bisdemethoxyl-curcumin. All three components are structurally similar, although curcumin seems to be the most effective constituent. Curcumin and these related curcuminoids appear to effect human health through antioxidant activity and possible modulation of 5-lipo-oxygenase (LOX) and cyclo-oxygenase (COX) enzymes.
The true health potential of curcumin always has been hindered by notoriously poor oral bioavailability. This has become generally accepted in recent years with numerous studies in humans demonstrating severe absorption shortcomings, even when curcumin is consumed in large quantities. As a result, researchers have sought ways to overcome this limitation of curcumin. One particularly useful strategy employs phospholipids to produce micelles, or curcumin phytosomes, that act as protective curcumin couriers.
The Phytosome Difference
Curcuminoids show a high affinity for biological membranes but are poorly soluble in water. However, when surrounded or “complexed,” with phospholipids such as phosphatidylcholine curcuminoids become dispersible in water. Phospholipids can have this sort of self-emulsifying effect for substances that are otherwise poorly soluble in water and the digestive tract.
But the phytosomes do more than just help overcome the poor water solubility of curcumin. They also appear to directly impact absorption by shuttling the curcuminoids inside enterocytes. This occurs because cellular membranes, including intestinal enterocytes, are largely composed of phospholipids, such as the phosphatidylcholine found in the phytosomes, allowing the phytosomes to act as vesicles that can be “folded” into the cell in a process called pinocytosis or cellular captation. The absorption technology found in Jarrow Formulas’ QH-absorb® works in a similar manner.
But that’s not all. The phytosome also appears to act as a barrier to the hydrolytic and enzymatic degradation known to affect curcuminoids in the digestive tract. As one example, curcuminoids are known to undergo retro-Claisen type reactions in the digestive tract, which converts them into their dihydro- counterparts altering their activity. Another example is glucuronidation reactions known to take place during the digestive process. Phytosomes are thought to be protective here as well.
Evidence of Success
Yet the evidence for the utility of curcumin phytosomes is not merely academic. In a human bioavailability study, healthy volunteers were randomly assigned to three groups and given either 1.0 g of Meriva, 1.9 g of Meriva, or 1.8 of regular curcumin powder. The overall increase of curcuminoid absorption from Meriva was ca. 29-fold (27-fold for the low 1.0 gram group and 31-fold for the 1.9 gram) on a curcuminoid equivalents basis. These results in humans are also corroborated by a pharmacokinetic study conducted with male Wistar rats that yielded comparable absorption increases.
Blood levels aside, the biggest question is do curcumin phytosomes work? In fact, multiple human clinical studies have demonstrated just that. In one study published in 2010, Meriva was given to 25 volunteers experiencing joint discomfort, while another 25 received a placebo. After three months of daily use, the Meriva group scored significantly better on the WOMAC scale (indicating joint comfort) and showed markers indicative of a more balanced inflammatory response. These results would appear to confirm the idea that increased stability and better absorption of curcumin induced by complexation with phospholipids, has clinical relevance.
Jarrow Formulas’ Curcumin Phytosome supports a healthy inflammatory response within the normal range and protects DNA against damage by free radicals and reactive oxygen species.
Meriva® is a patent-pending ingredient consisting of curcumin and phosphatidylcholine for increased absorption and bioavailability.
Clinical studies show that it promotes joint health and flexibility.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
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Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
PFAS pollutants causing turmoil
In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.
Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.
If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.
Why is glutathione so important for your health?
Glutathione is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, glutathione is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine.
There are a number of reasons why your body’s glutathione level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age.
Maintaining adequate levels of this antioxidant is incredibly important. Below are some of the best ways to increase your glutathione levels naturally.
What causes gall stones and how to get rid of them?Many people suffer from gallstones. While it's possible to have gallstones and not know it, severe cases can lead to rupturing of the gallbladder and even death. Understanding your gallbladder and naturally supporting it with the right nutrition is imperative for good health.
Should I worry about my cholesterol levels?Recently, new guidelines were introduced for what is deemed to be a healthy cholesterol level. While formerly, it was adviced to introduce cholesterol lowering drugs when your 'bad' cholesterol level amounted to over 2.5 mmol/litre, that number now dropped to 1.8.
This big drop will probably result in a vast increase of people that are being administered cholesterol lowering drugs.
But what if I told you, cholesterol is a poor marker for heart health?
For decades, cholesterol testing has served as that warning for many. An elevated level of "bad" LDL cholesterol has been just the warning people needed to change their ways. It has played that role for several reasons. People like tests because the results seem objective. Reliable measurement of cholesterol is easy and relatively inexpensive. It makes sense biologically. LDL cholesterol, a protein-wrapped package containing fat and cholesterol, tends to slip out of the bloodstream and lodge in blood vessel walls, forming the plaque that leads to clots and heart attacks.
And it makes sense statistically. The correlation between lowering your LDL and lowering your chances of having a heart attack or developing other forms of heart disease is well documented. Indeed, exercise and dietary changes are good for the heart partly because they lower LDL cholesterol levels.
Why is turmeric such a magical herb?
Recently, it became once again evident how mainstream media is being manipulated by Big Pharma to scare the public away from using well-known and empirically proven supplements towards using pharmaceutical medicine.
One such health scare tactic was aimed towards the use of curcumin, which has become one of the most popular health supplements , among which to support people recovering from breast cancer.
Apparently, one effect of curcumin is that it speeds up detoxification processes in the liver, which results in medicine being broken down more easily.
In this particular health scare, that's an undesirable side-effect because tamoxifen, a frequently used post-treatment drug, is also broken down more rapidly and hence, becomes less effective at lower dosages, when combined with high dosages of curcumin.
While this was touted as proof how dangerous it is to take unproven herbal supplements, this is nothing out of the ordinary. Many other products can speed up the liver detoxification process, with the most famous of them being the mood-enhancing herb St. John's Wort.
However, there are other products that do the contrary, among which grapefruit as well as green tea , which slow down the same detoxification liver enzyme.
Some of you may not be aware yet why both turmeric and curcumin have become such popular condiments as well as food supplements. Therefore we present you a breakdown on what curcumin is about.
Phospholipids as the foundation of a healthy mindThere are many components of brain health. That is why there is such a wide range of brain supplements, which run from amino acids like acetyl-L-carnitine or herbs such as Ginkgo biloba or Bacopa monniera to fish oil and omega-3 fatty acid DHA specifically, up to to vitamin B12, and vinpocetine.
Some cognitive supplements target stress and mood.
Others power brain cells with amino acids like acetyl-L-carnitine and glutamine.
Botanicals like ginkgo biloba and vinpocetine help promote circulation in the brain.
Still other cognitive supplements like curcumin or green tea address oxidation and inflammation.
Obviously, the brain’s structural health is key to such functions as memory and cognition, including mental energy, focus, and concentration. Maintaining structural integrity includes keeping brain cells healthy: ensuring cell walls remain fluid so that they can effectively regulate nutrients coming in and waste going out, and supporting signal-transmitting chemicals in the brain called neurotransmitters.
Lipids and more specifically phospholipids, are especially crucial to the health of both cell membranes and neurotransmitters.
History of conventional cancer treatmentsThere isn't a single person alive who hasn't experienced how a family member or loved one died because of cancer.
For myself this was most dramatically present in my mom and her sister who both developed breast tumors in the late 70s.
While my aunt chose to get treated conventionally, my mom chose the other path and went to a doctor who practiced an alternative diet-based therapy. In the end both died, my aunt of breast cancer, and my mom of a massive heart attack when her (then considered) atypical symptoms were unrecognized in hospital.
Since then I've been watching with both disgust and admiration how science has ben progressing. Disgust because conventional science kept ignoring the positive impact alternative medicine, along with diet and lifestyle can have on health. Admiration because of the major advances that have been made using ever less disruptive and dangerous approaches.
While it sometimes may seem as if cancer is a modern disease, nothing could be further from the truth. Cancer occurrences have been noted throughout history.
What are free radicals?The body is under constant attack from oxidative stress. Oxygen in the body splits into single atoms with unpaired electrons. Electrons like to be in pairs, so these atoms, called free radicals, scavenge the body to seek out other electrons so they can become a pair. This causes damage to cells, proteins and DNA.
Free radicals are associated with human disease, including cancer, atherosclerosis, Alzheimer's disease, Parkinson's disease and many others. They also may have a link to aging, which has been defined as a gradual accumulation of free-radical damage.
Substances that generate free radicals can be found in the food we eat, the medicines we take, the air we breathe and the water we drink. These substances include fried foods, alcohol, tobacco smoke, pesticides and air pollutants.
Free radicals are the natural byproducts of chemical processes, such as metabolism. Free radicals can be seen as as waste products from various chemical reactions in the cell that when built up, harm the cells of the body.
Yet, free radicals are essential to life. The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders.
Why do we get the flu in winter?Being cold doesn’t literally make you catch a cold, but it certainly seems likely how the coldest season is, as a matter of fact, the 'cold' season. Why is there a substantial increase in common colds and flus as soon as it gets cold outside?
The flu really does thrive in winterThere’s no doubt that the flu virus somehow thrives in the cold.
As it turns out, the virus is basically designed to jump from person to person when the air is cold and dry. Studies have shown that transmission rates are highest when temperature and humidity are both low. Because cold air naturally holds less water, low humidity levels are typical for winter.
Even when we make our homes comfortably warm, the air stays just as dry unless we use a humidifier.
But why do viruses thrive in cold air?Cold air may help the flu virus survive longer outside of a human host, making it easier to linger after a cough or sneeze. And apparently the virus does a better job of circulating in low humidity.
An infected individual exhales virus encased in tiny water droplets, and those droplets evaporate more quickly if the air is dry. If the flu droplet shrinks fast enough, it can become so light that it circulates around in the air instead of falling to the ground.
Magical turmericTurmeric (Curcuma longa) is a spice grown in India and other in tropical countries in Asia . This spice has been part of religious ceremonies in India for thousands of years. Turmeric is related to ginger with which it shares some of its active ingredients.
What causes muscle soreness?Delayed onset of muscle soreness (DOMS) is a type of pain that most will experience after doing unusual exercise for the first time. There have been several theories to as what causes muscle soreness. At first lactic acid was blamed, but lactic acids disappears quite rapidly and the time period between exercise and soreness too large.
Take 1 capsule per day with food.
For enhanced joint protection, take 1 capsule 2 times per day or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
Meriva 500mg †
curcumin phytosome phosphatidylcholine complex (Curcuma longa, rizome with 18-22% curcuminoids)
† = Recommended Daily Intake not established
active ingredient (curcumin phytosome phosphatidylcholine complex), filler (cellulose, magnesium stearate from palm oil), anticoagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans