Jarrow Formulas L-Citrulline is a substrate in the cycle that includes L-arginine and L-ornithine. L-Citrulline supports nitric oxide production, which is important for blood pressure regulation, immune function, healing, as well as helping the liver detoxify ammonia.
Quatrefolic® (Methyl Folate) is the 4th generation of methyl folate which can cross the blood-brain barrier. Methyl Folate is needed to support cardiovascular and neurological health as well as proper cell division.
Gamma tocopherol provides protective capacity from reactive nitrogen species, including nitric oxide beyond its immediate area of utility, that can damage lipids, proteins, and DNA.
Folate and gamma tocopherol work with L-Citrulline to support the production of nitric oxide. Quatrefolic® is a registered trademark of Gnosis
Nitric oxide (NO) is a very simple molecule--composed of one atom of both nitrogen and oxygen--that plays a number of complex biochemical roles. It is a gas and has an extremely short half-life (i.e. seconds) in blood, which allows it to be an effective, transient, short- range signaling molecule.
NO is most prominently known for its effects on blood vessel vasodilation—or relaxation. In fact, the 1998 Nobel Prize in Physiology or Medicine was awarded to a trio of researchers for “for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system.”
Jarrow Formulas’ L-Citrulline with 5-methyltetrahydrofolate (5-MTHF) and gamma-tocopherol is designed to support NO production and signaling through complementary modes while balancing related nitrogen cycles.
Maxing & Relaxing Citrulline
L-citrulline is a non-essential alpha amino acid that is a precursor to L-arginine and derives its name from watermelon, Citrullus lanatus. Watermelon is one of the best food sources of citrulline, but is only present in small quantities (0.7-3.6 mg per gram fruit). L-citrulline is also produced from glutamine and ornithine in the intestinal mucosa. This is one reason why bowel problems, such as celiac disease, can lead to depressed levels of citrulline and arginine. In fact, citrulline levels are used as a biomarker of proper bowel function.
Once absorbed, citrulline passes through the liver unchanged and reaches the kidneys where it is converted into arginine and circulated throughout the body. About 75% of the citrulline that reaches the kidneys is converted to arginine. Arginine is a precursor to nitric oxide; but, interestingly, citrulline increases blood levels of arginine more than consuming arginine itself. In contrast to citrulline, ingested arginine is metabolized to urea to a large degree. Contrary to common supplement sense, L-arginine may not support positive nitrogen balance quite as well as is believed due to this conversion to urea.
Many sports and gym enthusiasts seek to increase NO production in an effort to widen blood vessels via endothelium-dependent nitric oxide mediated vasodilation. The rationale is that better gas exchange and nutrient delivery, including amino acids to regenerate muscle, that result from increased blood flow through widened vessels will lead to increased performance and quicker recovery. L-citrulline is a better means to support nitric oxide levels than consuming large quantities of arginine. Animal data also suggests that L-citrulline can improve endothelium-dependent vasodilation, relaxing arterial smooth muscle by an effect on cyclic-GMP.
Methylfolate & Nitric Oxide Synthase
Folate is a generic name for a naturally occurring family of compounds containing a pteridine ring linked to p-aminobenzoic acid and containing a polyglutamate tail. Folic acid is simply the pteridine ring without the polyglutamate tail. The production of the active form of folate in the body, 5-methyltetrahydrofolate (5- MTHF, a.k.a. methylfolate), requires two hydrogenation steps and a methylation reaction. However, the final conversion step from methylene-THF to 5-MTHF is lacking in 10% of the population. Another 40% convert only a limited amount. For these people, folic acid utility at questionable levels and elevated homocysteine levels may be observable.
The connection to cardiovascular and blood pressure health may be more intimately related to another critical biomolecule, tetrahydrobiopterin (BH4), than to homocysteine per se . BH4 is an essential cofactor for nitric oxide synthase (NOS) and possesses the same structure as the head-group of methylfolate minus the methyl group. Since methylfolate is structurally similar to BH4, it looks and acts the same in some areas of the body. As such methylfolate can fit into the active sites of native BH4 enzymes and send similar messages. This is the case with a form of NOS expressed in the vicinity of blood vessels, endothelium dependent nitric oxide synthase (eNOS). In fact, methylfolate has been found to exert beneficial effects on blood pressure regulation by modulating endothelial function and vascular superoxide production, preventing peroxynitrite-mediated BH4 oxidation, and improving eNOS coupling.
Jarrow Formulas’ L-Citrulline supports nitric oxide production, which is important for blood pressure regulation, immune function, healing, as well as helping the liver detoxify ammonia. Quatrefolic® (Methylfolate) is a biologically active form of folate needed to support cardiovascular and neurological health. Gamma tocopherol works with L-citrulline and methylfolate to support the production and function of nitric oxide.
Forget about exercising to lose weight: you can't outrun a bad diet!
Set point and holiday weight gain
Tips and tricks to keep your house cool without airconditioning
After having survived the hottest two weeks of the past century, and hearing about the deliberate choice to switch of the power in some areas of California as it became impossible to match the demand for electricity, due to the massive use of airconditioning, this week's topic had to be about how to keep your house and yourself cool without needing to rely on energy-guzzling airconditioning.
How to make better food and lifestyle choices
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
Everything really started with an advertisement in an American muscle magazine with the name MM2K (Muscle Media 2000) for a product called DHEA
At the time, MM2K was a revolutionary magazine because they didn't tell you lies about doping use in sports and bodybuilding and strength sports in particular, unlike other magazines that were solely focused on inspirational stories and faking how bodyubuilding was a doping-free sports.
By contrast, MM2K wrote openly about doping, supplements, nutrition, training, and other gossip stories about health, sports and politics.
MM2K had great contributing authors, such as Bill Philips himself, Dan Duchaine who was seen as the 'mad scientist' and Charles Poliquin, a well-respected personal trainer. Dan Duchaine wrote extensively about diet drugs, which he wrote down in his booklet 'Dirty Dieting', which would become the starting point for more diet books written by Lyle McDonald.
Can training with just weight machines make you stronger?
Whomever has been a member of a gym in the past 15 years, will have noticed how slowly but surely, machines have taken a back seat and more and more space is given to 3-dimensional weight equipment, like suspension (TRX-)trainers, gym balls, kettle bells and even fun stuff that was formerly unheard of like pole dances and climbing walls.
A very popular trend is the development of Cross-Fit in which both strength and endurance is equally valued and in which Olympic weightlifting exercises are also incorporated.
As someone who has dabbled both in Olympic and power lifting as well as endurance cycling, I've been very happy about this development even though I keep using machines myself too. Recently, Christian Finn, a coach who specialized in rehab training, pointed out how machines have a more important role than most of us realize. It's well worth sharing it in our blog, too.
How to make a habit out of good intentions
Sometimes you stumble on articles, that are too good to pass up on. For those who have started the year with good intentions, we are sharing an article on how to make a habit out of good intentions. It's written by a guy who changed his habits after he became a father and wanted to be a good parent by setting an example.
“Your net worth to the world is usually determined by what remains after your bad habits are subtracted from your good ones.”
You probably agree with that statement.
But, for you (and everyone else) the problem is that good habits are hard to form and bad habits are easy to keep.
It is certainly true for me. Like most of us, I meant to start exercising for about six years after I started my career.
But it never happened. I’d do it for two or three weeks here and there, but nothing that ever stuck.
Then, all of a sudden, it did.
And it did because something changed for me. I had a son that was old enough to mimic me and that I wanted to be able to keep up with for the next twenty years. That scared me straight essentially.
In a number of areas in my life, including fitness, I realized he was going to base a significant portion of his view of how to live life and what habits were important off of what he watched me do.
So I stopped acting like I was going start exercising and I actually did it.
To create my new habit, I used a combination of the techniques below. You can use them to firm up your new habit and get your good habit quotient up.
Keto diets for endurance athletesMany of us will have heard of the advantages of very low carb diets for obese patients and more specifically for diabetics. Going very low carb results in not having as much hunger and much healthier blood glucose levels. Another group that often goes on a keto diet are those who want to prevent tumour growth.
Don't sabotage your virility!
Plasticizers are additives of which phtalates are the most abundant ones (and bisphenol-A or BPA the best known) that are used to increase the flexibility or plasticity of the material to which they are added, normally rigid plastic and as additives in paint and adhesives.
Phtalates are not just found in obvious plastic packaging, building materials and toys, but also in fragrances, cosmetics, shampoo, shaving cream, and other cleaning detergents.
Blood flow and vasodilationVasodilation is the process by which the blood vessels in the body relax and widen, allowing for greater blood flow. One of the main triggers of vasodilation is nitric oxide (NO).
Therefore, anything that increases nitric oxide production in the body will also increase vasodilation.
Wat is citrulline?Citrulline dat verkwikkend werkt op de spieren, lichamelijk welbevinden en dus op het prestatievermogen. Citrulline is zowel een precursor voor de essentiële aminozuren arginine en ornithine en daardoor een precursor voor stikstof (NO), wat inwerkt op zowel de geslachtsorganen als op die spieren, waar het helpt bij de afvoer van melkzuur en de spieren gevoeliger maakt voor het spieropbouwende / spierherstellende hormoon testosteron.
Take 1 tablet per day with food or as directed by your qualified healthcare professional.
contains per daily serving (1 tablet)
L- citrulline (free form) 1000mg †
folate (as Quatrefolic®) (6S)-5-methyltetrahydrofolic acid glucosamine salt) 30mcg 8% RDI
gamma tocopherol 10mg †
(from natural mixed tocopherol complex)
† = Recommended Daily Intake not established
active ingredient (L-citrulline,gamma tocopherol and folate), filler (cellulose, vegetable stearic acid, modified food starch) , anti-coagulant (silicon dioxide), filler (vegetable magnesium stearate) and food-grade coating
store in a cool, dry place
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially blood pressure medications), consult your healthcare professional before using this product.
The elderly should frequently check B12 status; folic acid may mask pernicious anemia.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians/vegans