Citicoline 250mg 120 capsules value-size - CDP Choline improves long-term memory | Jarrow Formulas

Citicoline 250mg 120 capsules value-size - CDP Choline improves long-term memory | Jarrow Formulas

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brand:Jarrow Formulas
brand ingredient:Cognizin®
best before:Feb 2023
appearance:gelatin caps
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Jarrow Formulas Citicoline 120 capsules which is stabilized CDP Choline (cytidine 5’diphosphocholine) and a naturally occurring, water soluble, biological compound that is an intermediate for the synthesis of phosphatidylcholine, a major constituent of the grey matter of brain tissue (30%). Supports memory recall and learning among a host of other cognitive support.

Scientific research demonstrates that Citicoline consumption promotes brain metabolism by enhancing the synthesis of acetyl-choline, restoring phospholipid content in the brain and affecting neuronal membrane excitability and osmolarity (by its effect on the ATP-dependent sodium and potassium pump).

who can benefit from cicitoline?
Although anyone can benefit from citicoline, it is primarily a supplement used to improve thinking, learning and memory for older people.
While safe, citicoline is so effective, it has been placed on the list of banned substances for athletes.

key benefits
• improves cognitive ability (learning)
• helps with long term memory

background reading
Nutrition for the brain
The basic building blocks for important neurochemicals, especially acetylcholine, are less available and less efficiently used by the aging brain. One reason is that the same age-related changes of the vascular system which diminish heart function can negatively affect the blood supply to the brain. Moreover, even the ability of the blood to carry and release oxygen is subject to decline.

Other factors involved in mental decline reflect undesirable general changes within the body. For instance, the body’s ability to produce the basic energy unit which powers metabolism, adenosine triphosphate (ATP), declines over time. Similarly, the brain’s capacity to metabolize glucose for energy goes down with age.

Although the causes of mental decline are diverse, a few basic changes are common to most forms of deterioration which affect the brain. Reduced synthesis of necessary neurotransmitters, decreased circulation and diminished cellular efficiency are the enemies of sound memory and mental clarity. Somewhat surprisingly, phospholipids can influence all of these areas responsible for brain health

Citicoline for learning and memory
Phospholipids are the principal components of all cell membranes. These membranes might be envisioned as internal and external walls which are permeable, yet relatively solid and stable in comparison with their more fluid core. Within this semifluid core float proteins which act as switching and control mechanisms for cellular processes. The membrane consists of a single layer of cholesterol with a layer of phospholipids, and their attached polyunsaturated fatty acids. These supply the building blocks for prostaglandins, immune components, regulatory signals and other physiologically important processes. Some phospholipids, primarily the inositols are especially active in cell signal regulation. The cholines are preferentially involved in the functioning of various neurotransmitters and in the production of acetylcholine, although they influence other brain mechanisms as well.

Citicoline: clinically supported
Citicoline (cytidine 5’-diphosphocholine, also called citicoline) is a donor of choline for use in the synthesis of phosphatidylcholine and the neurotransmitter acetylcholine in the brain. Clinical experiments have shown a reactivation of brain mitochondrial ATPases and the Na+/K+ ATPases when this compound is orally administered. There may also be improvements in the regulation of blood flow and neuroimmune responses in the brain.

The compound has been tested extensively in clinical trials in the areas of memory, verbal memory, recognition, recall, and cognitive abilities. These are all areas in which membrane permeability, choline and other neurotransmitters are known to be important. Cholinergic compounds and the brain neurons which make use of them play especially significant roles in learning and memory. Recent studies have indicated improved visual acuity as well.

Citicoline is a molecule that consists of cytidine and choline joined together. It is almost completely absorbed and equally bioavailable whether given orally or by injection. Once Citicoline is ingested, it is broken down into its component parts, and these readily cross into the brain and central nervous system. Both components are incorporated into the phospholipid fraction of the membrane and microsomes. Citicoline activates the biosynthesis of structural phospholipids e.g. phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine in the neuronal membranes, increases cerebral metabolism and acts on the concentration of various neurotransmitters.
Increased levels of phosphatidylcholine, noradrenaline, acetylcholine and dopamine have been demonstrated in animal trials with the administration of Citicoline.

Why citicoline?
Researchers have theorized that Citicoline may also be effective in helping brain cells prevent the buildup of different toxins, as well as enhancing neuronal functions and promoting the production of proper levels of neurotransmitters. These effects reflect not just the impact of Citicoline upon the synthesis of acetylcholine, dopamine and noradrenaline, but also its indirect impact upon membrane health and transport through the improved production of phosphatidylcholine and phosphatidylserine (PS).

It might seem that the obvious way to increase phosphatidylcholine levels in the brain would be to supplement with phosphatidylcholine itself. Phosphatidylcholine is a good supplement, but it may not be absorbed as fully as is Citicoline

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best before:
Feb 2023
  • gelatin caps
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Feeling sad and stressed due to COVID-lockdown?

Depression in winter time is quite normal, because we aren't exposed to the vitamin D-generating sunrays, which also enhances immunity levels. Fortunately, we can take vitamin D supplements to combat seasonal depression as well as enhance immunity levels.

Another way to chase sadness away is by celebrating, no matter whether that's Sinterklaas, Winter Solstice, Hanukkah, Christmas or New Year. We will decorate our houses, exchange gifts and overeat , get a bit tipsy and enjoy ourselves.
This year is different: restaurants, shops and even gyms need to close down and we are not allowed to gather together in groups. Lack of entertainment, retail therapy and exercise will make it much more difficult to overcome feelings of depression.
It gets worse when you are among those who work in the tourism or entertainment industry and have lost your job as well as most of your income.

For now it is probably best to just accept the current state of affairs and try to console yourself with non-edible goods, such as nice music with a good book, entertaining movie, and aromatherapy (perfume/room fragrances).
And, weather permitting, put on your walking shoes and go for a long walk in the forests or local park.

But perhaps you have been feeling too stressed to enjoy whatever you still can do to relax? Or you were already feeling sad before COVID-19 came along? In that case, DHEA might help.

Are eggs good or bad for diabetes?

Outside COVID-19 very little health news catches the attention of newspapers, unless it is something out of the ordinary.

One such news item was the result from an observational study among Chinese citizens of whom it was reported how those eating more eggs had a higher risk of diabetes 2.

Oh boy, here we go again was my first thought. First eggs were vilified due to their cholesterol content, and now that nonsense has been put to rest [link], they try to come up with another BS research. Yes, calling it BS.
Imagine, you are a notorious smoker and decide to give up smoking because your lungs are suffering and have developed COPD. Yet, it is too late and a lung tumour has been detected. Guess what? The clickbait headlines would go like "people that give up smoking, will develop lung cancer!".

That's how it works! Time and again we have to repeat: correlation is NOT the same as causation. This was an observational study, in which people were asked about their habits.
A much better research method is a clinical study in which people are meticulously followed after treatment.
Or a meta study in which several studies are lumped together and analysed.

Skin hunger: why we crave touch

As we are in the midst of the Easter Holiday, we can't help but feel sad. While Mother Nature is showing abundant signs of spring during a period of incredibly sunny weather, we are barely allowed to go outside other than to do what is absolutely necessary. Our gyms have been closed for almost a month now while in some countries, people aren't even allowed to exercise. Not just group exercise, but also to just jump on a bike and go for long rides. 

While couples and families get grumpy from living together in a cramped space, others face different problems: they are living without any companion whatsoever. Therefore it's not a miracle how all of a sudden, pet asylums have been able to 'clear out' their list of unwanted pets. Not just because people have more time at hand to walk a dog (just about the only thing some are allowed to do) but also because they crave the ability to touch a living being, for lack of being able to touch another human.

Somehow, just like the sense of smell is overlooked, this also is true for the sense of touch. Only when we lose it, we crave it. This craving also is called 'touch hunger' or 'skin hunger'.

How to beat andropause, the condition that ails all elderly males

Andropause is a medical condition, similar to the female menopause, that can affect men between the ages of 40 and 65. Men do not have a clear-cut signpost to mark the transition. In women estrogen drops dramatically at menopause, but testosterone levels in men drop very gradually over many years and decades. The bodily changes in andropause occur very gradually in men and may be accompanied by changes in attitudes and moods, fatigue, a loss of energy, sex drive, stamina, and physical agility.
Andropause may be triggered not only by declines in testosterone, but in the "female" hormone estrogen as well.

There is a growing interest, as well as a booming industry, in the use of testosterone therapy for middle-aged and older men. This interest has led to the definition of a new condition, termed 'andropause' implying that this condition is due to falling levels of testosterone. This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence. Is testosterone therapy appropriate for men with symptoms of male menopause? There is no scientific agreement on this topic.
But it stands to reason that hormones should be used only as a last resort since they have serious risks if misused.

Six reasons why eggs are awesome superfoods

Eggs are so nutritious they can be nicknamed nature's oldest superfood.
Eggs are abundant in essential vitamins and minerals as well as unique antioxidants and brain nutrients many people are lacking in their nutrition when they don't eat eggs regularly.

Here is a breakdown of the six reasons why eggs are such an awesome food choice

Phospholipids as the foundation of a healthy mind

There are many components of brain health. That is why there is such a wide range of brain supplements, which run from amino acids like acetyl-L-carnitine or herbs such as Ginkgo biloba or Bacopa monniera to fish oil and omega-3 fatty acid DHA specifically, up to to vitamin B12, and vinpocetine.

Some cognitive supplements target stress and mood.
Others power brain cells with amino acids like acetyl-L-carnitine and glutamine.
Botanicals like ginkgo biloba and vinpocetine help promote circulation in the brain.
Still other cognitive supplements like curcumin or green tea address oxidation and inflammation.

Obviously, the brain’s structural health is key to such functions as memory and cognition, including mental energy, focus, and concentration. Maintaining structural integrity includes keeping brain cells healthy: ensuring cell walls remain fluid so that they can effectively regulate nutrients coming in and waste going out, and supporting signal-transmitting chemicals in the brain called neurotransmitters.

Lipids and more specifically phospholipids, are especially crucial to the health of both cell membranes and neurotransmitters.

Nootropics, what are they and how do they work?

Nootropics is the accepted term for substances that enhance learning and memory function.
Nootropics work in various ways depending on the characteristic of the substance.
Some work by enhancing oxygen transport to the brain, an improved energy turnover in the brain, better neurotransmitter availability, or enhancing the creation of other substances that influence brain activity.

Uridine for a healthy brain and liver

Uridine supports formation of brain synapses and neuronal membranes 

Uridine is a nucleotide that acts as a precursor of brain synapses and membrane phospholipids in conjunction with the omega-3 fatty acid docosahexaenoic acid (DHA) and choline sources. It may enhance some brain cholinergic functions.
Uridine also supports the health and function of liver mitochondria.

Why do you look so familiar?

A common characteristic of most succesful politicians is their ability to remember people's names and faces very well. They have to, as networking is very important to them.

Seize the day, crack an egg?

In the past week, a discussion started between a dietician-foodie and a paleo/fitness-foodie, who embraced eating eggs without really giving a lot of arguments. The dietician wrote a critical article (in Dutch) to show the flaws of that bold statement.

Memory training

Do you tend to forget details more easily than before? Here are tips to stay ahead of the memory game.
Believe in yourself: if you believe to have a poor memory, you will unconsciously not make enough effort and as a result, fulfill the prophecy.

"Please pass my smart drugs ..."

Years ago, when I had just stopped with a study Nutrition and Dietetics" and started an enterprise, but needed another job to finance it, I made a new friend whose life was devoted to study smart drugs.

recommended use
take 1 capsule with a meal once or twice a day

contains per daily serving (1 capsule)
Citicoline (Cognizin® Brand) from stabilized cytidine 5'diphosphocholine) 250 mg†

RDI = Recommended Daily Intake
† = RDI not established

active ingredient (cytidine 5’diphosphocholine), anticoagulant (silicon dioxide), filler (vegetable magnesium stearate, cellulose), softgel capsule (BSE-free bovine gelatin)

store in a cool, dry place
keep out of reach of young children

allergy information
contains lecithin derived from soy
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

contains gelatin

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