Carnosine 90 capsules - dipeptide alanine-histidine | Jarrow Formulas

Carnosine 90 capsules - dipeptide alanine-histidine | Jarrow Formulas

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Jarrow Formulas L-Carnosine is a dipeptide that is found in the brain, heart, skin, muscles, kidneys and stomach.

who can benefit from L-Carnosine?
Vegetarians and anyone interested in anti-aging can benefit from L-carnosine.

how does L-carnosine function?
L-Carnosine supports healthy aging and cellular rejuvenation by its effects on two mechanisms: Glycation and Free Radical Damage.

Glycation is the uncontrolled crosslinking of sugar molecules to proteins and is implicated in loss of cell function, genome integrity and accelerated aging. L-Carnosine also protects against accelerated brain aging by reducing lipid peroxidation and stabilizing cell membranes.

what distinguishes L-Carnosine?
Jarrow Formulas L-Carnosine provides the highest quality L-carnosine available

background reading
L-Carnosine: the little dipeptide that could
Good things sometimes come in small packages. The amino acid derivative L-Carnosine is one of these. Chemically, it is a dipeptide (a molecule consisting of two amino acids) constructed from beta-alanine and L-histidine, hence its chemical name alanylhistidine.

L-Carnosine is found throughout the body, but it is particularly abundant in those cells which are long-lived, such as the nerve cells (neurons) and the cells of the muscles (myocytes). Similarly, L-Carnosine, as is true of the antioxidant enzyme superoxide dismutase (SOD), is one of a handful of compounds that are present in tissues at levels that correlate strongly with the maximum life spans of animal species. Research interest in L-Carnosine is focused on a number of issues arising from the ability of the compound to rejuvenate cells approaching senescence (failure due to advancing age).

Muscle levels of L-Carnosine decline approximately 63% between the ages of 10 and 70. Brain levels of L-Carnosine begin high and remain high in comparison with the levels found in most other tissues. Scientists have speculated that this may be one reason that brain functioning is stable into old age despite the brain’s dependence upon glucose for energy metabolism and the unusually high ratio of fructose to glucose in the brain. L-Carnosine supports healthy aging and cellular rejuvenation by its effects on two important mechanisms: glycation and free radical damage. It also detoxifi es aldehydes and chelates metal ions which otherwise might be free to cause damage by generating free radicals

Protecting against free radicals and more
Tests prove that L-Carnosine provides protection against a wide range of reactive oxygen species including the hydroxyl, superoxide, and peroxyl radicals as well as singlet oxygen. Such a breadth of protection makes L-Carnosine one of the most efficient of free radical scavengers and antioxidants available to the body.

Metal ions, such as copper and zinc, are closely linked to free radical generation. Indeed, changes in the brain’s copper-zinc metabolism are implicated in many age-related cognitive problems. L-Carnosine counteracts these effects not only by scavenging the radicals directly, but also by chelating excess metals and by buffering the pH (acid-base) of brain tissues.

Stopping the formation of AGEs & brain protein carbonylation
The proteins which make up the tissues of the body can readily be damaged as a result of oxidation and interactions with sugars or aldehydes.

The major forms of undesirable protein modifications include free radical damage, carbonylation (attachment of carbonyl groups to proteins), cross-linking, glycation and advanced glycation end product (AGE) formation. All of these changes damage a protein’s ability to function normally.

Glycation refers to the oxidation of protein by glucose. In chemistry, these are sometimes called “browning” reactions, and, in fact, they are seen every time meats are “browned” by cooking. The result is a cross-linking of glucose or another sugar molecule to the protein, an action which effectively prevents the protein from acting properly.

Another and closely related type of damage to proteins is the formation of extraneous carbonyl (CO, carbon/oxygen) groups. Some authorities estimate that in older adults, one third of all proteins may become carbonylated, with a resulting decline in a variety of cellular functions. Glycation, the actions of aldehydes and peroxidation agents, etc., can all lead to protein carbonylation. L-Carnosine has been shown to “sacrifice” itself as a substitute victim to glycating agents, thus sparing the proteins and membranes which otherwise would have been the targets of glycation. Furthermore, there is evidence that L-Carnosine reacts with and removes the carbonyl groups of glycated proteins.

Promoting cellular rejuvenation
The ultimate test of cellular rejuvenation is the way in which an animal ages. A Russian study tested the effect of carnosine on life span and indicators of senescence in age-accelerated mice by giving half the mice carnosine in their drinking water starting at two months of age. At the conclusion of the study, the mice given carnosine were about twice as likely to reach the “ripe old age” of 12 months as were untreated mice.

code GTIN:
0790011150527
code MPN:
LCAR-115052
brand :
Jarrow Formulas
best before:
Feb 2022
appearance:
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audience :
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  • vegetarians
diet:
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  • hypo-allergenic
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  • 12+ items = -25%
quantity discount:
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  • any 3+ = -5%!
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  • keep out of reach of young children
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Forget about exercising to lose weight: you can't outrun a bad diet! 

A few days ago, an article showed up in my newsfood about a remarkable result of research done on the Hadza tribe in Tanzania, which still leads a traditional hunter-gatherer lifestyle. 
Despite walking an average of a multiple of ten thousands of steps every day, they barely need more calories than the average couch potato in a Western country. 
That same day I discussed with an old friend who had read the same news story. He told me how he had trained for a marathon in the past, but barely dropped any weight while doing so. Only when he spent a week on liquid foods at a spa, he succeeded in losing weight which he mostly thanks to the relaxed environment. Otherwise it was next to impossible. Apparently his body really clung to its precious body fat! 
 
But how was this possible? We didn't really know though we had our suspicions. I I could tell much about the same story. Yes, I'd drop weight pretty fast in the first few weeks of the cycling season or on a longer cycling holiday, but would get stuck at my regular (still too heavy) summer weight while I wasn't really inhaling tons of food. Except then for the Route des Cent Cols during which I could barely eat enough to stay fit and sleep well for all those mountains. 
 
Let's find out more about this particular research!
 
When Herman Pontzer set off for the rugged savannah of Tanzania to spend a summer with the local Hadza people, he thought he knew what he would find. As an evolutionary biologist, his aim was to measure how the Hadza’s hunter-gatherer lifestyle causes them to burn more energy. Because we all know the more exercise you do, the more calories you burn and the slimmer you become, right? Well no, not exactly.
Don’t expect any meaningful weight change in the long term from exercise alone.”
 
What Pontzer and his fellow researchers discovered flew in the face of received wisdom about how our metabolism works. Although the Hadza lead far more active lives than ours – routinely walking long distances, they undertake more physical activity daily than the typical American does in a week – their energy expenditure was no greater. They were burning the same number of calories as men and women from industrialised populations. Our bodies, concluded Pontzer, seem to maintain daily energy expenditure within a narrow window, no matter what lifestyle we lead. While obesity is largely caused by overconsumption, it appears there’s little we can do to change the calories we burn.
 

What causes night blindness?

People with night blindness experience poor vision at night or in dimly lit environments, for which the medical term nyctalopia is used.

Although the term “night blindness” implies that you can’t see at night, this isn’t the case. You may just have more difficulty seeing or driving in darkness.

Some types of night blindness are treatable while other types aren’t. Once you know the cause of the problem, you can take steps to correct your vision.

PFAS pollutants causing turmoil

In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.

Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.

If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.

Glycation and aging

Glycation refers to the oxidation of protein by glucose. In chemistry (and cooking), these are called “browning” reactions, and, in fact, they are seen when meats are “browned” by frying. The result is a cross-linking of glucose or another sugar molecule to the protein, an action which effectively prevents the protein from acting properly.
Glycation is a major cause of the aging process and especially devastating to diabetics.

Memory training

Do you tend to forget details more easily than before? Here are tips to stay ahead of the memory game.
Believe in yourself: if you believe to have a poor memory, you will unconsciously not make enough effort and as a result, fulfill the prophecy.

recommended use
Take 1 capsule, 1 to 3 times per day with juice or water on an empty stomach, or as directed by your qualified health care consultant.

contains per daily serving (1 capsule)
L-carnosine (beta-alanyl-L-histidine) 500mg†

† = Recommended Daily Intake not established

ingredients
active ingredient (beta-alanyl-L-histidine), filler (cellulose, vegetable magnesium stearate) , anti-coagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)

storage
store in a cool, dry place
keep out of reach of young children

contra-indication
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product.

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

vegetarians/vegans
suitable for vegetarians and vegans

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