Bone-Up 360 capsules value-size - calcium (MCHA) , magnesium, vitamin C, D and K | Jarrow Formulas
Jarrow Formulas Bone-Up 360 capsules provides StimuCal™ ossein MicroCrystalline HydroxyApatite (MCHA) from free-range New Zealand calves), which includes the superior combination of the inorganic calcium lattice of MCHA within an organic protein milieu.
StimuCal™ is rich in native type I collagen—the predominant protein found in bone—and has been clinically demonstrated not to disproportionately spike calcium blood levels as do other forms of calcium, such as the carbonate and citrate salt forms.
StimuCal™ is combined with vitamin D3 and vitamin K2 (as MK-7 from natural fermentation [a more bioavailable form of vitamin K]) to support the proper deposition of calcium into the bone matrix, thereby maintaining skeletal integrity, as well as supporting cardiovascular and arterial health.
Potassium citrate is a systemic alkalizer added for optimal osteo support.
- Complete Multinutrient Bone-Health System
- Published clinical trial with Bone-Up® StimuCal™ MicroCrystalline HydroxyApatite Complex, a Source of Natural Bone-Growth Factors
- Often Imitated Bone Supplement
- Ossein Microcrystalline Hydroxyapatite Contains Active Bone-Growth Factors
- Bone-Up® is Always UP-FORMULATED® to Include the Latest Breakthroughs in Bone Health
HEALTH CLAIM: Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis later in life.
Jarrow Formulas Bone-Up is the most advanced and complete nutritional regimen for maintaining strong, healthy bones. Bone-Up has been a featured product of Jarrow Formulas for some time and has been updated through the years to reflect the latest scientific findings regarding skeletal health.
Bone Mass and Hydroxyapatite
In 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fifty-three post-menopausal women diagnosed to have seriously impaired calcium absorption and accelerated bone loss were separated into three groups and studied for over 14 months. At the conclusion of the study, only the women that received 1,000 mg of calcium from hydroxyapatite along with vitamin D showed a significant increase in bone thickness.
Hydroxyapatite produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue.
Furthermore, hydroxyapatite provides both the organic and inorganic constituents found in human bone: hydroxyapatite microcrystals consist of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.
Bone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility.
Hydroxyapatite composes 67% of the weight of bone, and the collagenous fibers make up the remaining 33%.
The average adult has 1,000 -1,200 grams of calcium in the body. Bones are the body’s largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable.
Between 2 - 4% of a person’s skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be “remodeled” or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost.
It has been estimated that post-menopausal women lose 0.7% to 2% of their bone per year while men lose 0.5%-0.7%. Between 45 and 75 years of age, women lose 30% of their skeletal structure and men lose 15%.
Calcium Plus It starts with the finest source of calcium available: Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used). Skeletal health, however, requires more than calcium. Scientific evidence conclusively demonstrates the need for other nutrients like vitamin D3, vitamin K, potassium, magnesium, boron, and trace minerals such as zinc, copper, and manganese.
Who Needs to Supplement Calcium? Research has indicated that 85% of women over the age of 20 and at least 50% of men from age 35 consume less than the RDI for calcium. Caffeine, alcohol, sugar, chocolate, high protein diets and soda pops – particularly colas that are high in phosphorous can deplete calcium.
In addition, calcium absorption has long been thought to be stomach acid dependent, but both stomach acid production and calcium absorption decline with age!
Bone-Up Clinical Trial
The results of a recent clinical trial published in the Journal of Nutritional & Environmental Medicine (Disilvestro RA et al. J Nutr Environ Med 2007; 16(1):26-32) found that exercise and supplementation of calcium, vitamin D3 and other micronutrients from Bone-Up significantly improved bone health in young adult women.
In an 8-week double-blind placebo-controlled study of 24 female students ages 18 to 24, supplementation with Bone-Up (not placebo) was found to produce statistically significant decreases in markers of bone degradation, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OH-vitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.
For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®
- gelatin capsules
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- any 6+ = -12.5%!
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
take 1 capsule three times a day with a meal or as recommended by your qualified healthcare professional.
adult women (especially during menopause)
take 2 capsules three times per day (for a total of 6) with meals to facilitate maximum absorption, or as directed by your qualified healthcare professional.
contains per daily serving (6 capsules)
Vitamin C (calcium ascorbate) 200mg (220% RDI)
vitamine D3 (cholecalciferol) 1000 iu (130% RDI)
vitramin K2 (as MK-7) 45 mcg (40% RDI)
calcium (elemental from StimuCal microcrystalline hydroxyapatite (MCHA) 1000 mg (80 % RDI)
magnesium oxide 500 mg (120% ADH)
zinc (as zinc-L-methionine sulfate) 10 mg (90% RDI)
copper gluconate 1mg (110% RDI)
manganese (as citrate) 1mg (40% RDI)
potassium (citrate) 99mg (2% RDI)
boron (as citrate) 3mg †
RDI = Recommended Daily Intake
† = RDI not established
active ingredients (Microcrystalline Hydroxyapatite, calcium, phosphorous, magnesium, ascorbate, citrate, zinc, boron, copper, manganese, cholecalciferol, menaquinone), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), capsule (BSE-free bovine gelatin)
store in a cool, dry place
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, or taking medications (especially warfarin/Coumadin), consult your healthcare professional before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
contains gelatin and animal-derived calcium