Bone-Up 360 capsules - calcium (MCHA) , magnesium, vitamin C, D and K | Jarrow Formulas
Jarrow Formulas Bone-Up 360 capsules provides StimuCal™ ossein MicroCrystalline HydroxyApatite (MCHA) from free-range New Zealand calves), which includes the superior combination of the inorganic calcium lattice of MCHA within an organic protein milieu.
StimuCal™ is rich in native type I collagen—the predominant protein found in bone—and has been clinically demonstrated not to disproportionately spike calcium blood levels as do other forms of calcium, such as the carbonate and citrate salt forms.
StimuCal™ is combined with vitamin D3 and vitamin K2 (as MK-7 from natural fermentation [a more bioavailable form of vitamin K]) to support the proper deposition of calcium into the bone matrix, thereby maintaining skeletal integrity, as well as supporting cardiovascular and arterial health.
Potassium citrate is a systemic alkalizer added for optimal osteo support.
- Complete Multinutrient Bone-Health System
- Published clinical trial with Bone-Up® StimuCal™ MicroCrystalline HydroxyApatite Complex, a Source of Natural Bone-Growth Factors
- Often Imitated Bone Supplement
- Ossein Microcrystalline Hydroxyapatite Contains Active Bone-Growth Factors
- Bone-Up® is Always UP-FORMULATED® to Include the Latest Breakthroughs in Bone Health
HEALTH CLAIM: Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis later in life.
Jarrow Formulas Bone-Up is the most advanced and complete nutritional regimen for maintaining strong, healthy bones. Bone-Up has been a featured product of Jarrow Formulas for some time and has been updated through the years to reflect the latest scientific findings regarding skeletal health.
Bone Mass and Hydroxyapatite
In 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fifty-three post-menopausal women diagnosed to have seriously impaired calcium absorption and accelerated bone loss were separated into three groups and studied for over 14 months. At the conclusion of the study, only the women that received 1,000 mg of calcium from hydroxyapatite along with vitamin D showed a significant increase in bone thickness.
Hydroxyapatite produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue.
Furthermore, hydroxyapatite provides both the organic and inorganic constituents found in human bone: hydroxyapatite microcrystals consist of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.
Bone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility.
Hydroxyapatite composes 67% of the weight of bone, and the collagenous fibers make up the remaining 33%.
The average adult has 1,000 -1,200 grams of calcium in the body. Bones are the body’s largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable.
Between 2 - 4% of a person’s skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be “remodeled” or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost.
It has been estimated that post-menopausal women lose 0.7% to 2% of their bone per year while men lose 0.5%-0.7%. Between 45 and 75 years of age, women lose 30% of their skeletal structure and men lose 15%.
Calcium Plus It starts with the finest source of calcium available: Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used). Skeletal health, however, requires more than calcium. Scientific evidence conclusively demonstrates the need for other nutrients like vitamin D3, vitamin K, potassium, magnesium, boron, and trace minerals such as zinc, copper, and manganese.
Who Needs to Supplement Calcium? Research has indicated that 85% of women over the age of 20 and at least 50% of men from age 35 consume less than the RDI for calcium. Caffeine, alcohol, sugar, chocolate, high protein diets and soda pops – particularly colas that are high in phosphorous can deplete calcium.
In addition, calcium absorption has long been thought to be stomach acid dependent, but both stomach acid production and calcium absorption decline with age!
Bone-Up Clinical Trial
The results of a recent clinical trial published in the Journal of Nutritional & Environmental Medicine (Disilvestro RA et al. J Nutr Environ Med 2007; 16(1):26-32) found that exercise and supplementation of calcium, vitamin D3 and other micronutrients from Bone-Up significantly improved bone health in young adult women.
In an 8-week double-blind placebo-controlled study of 24 female students ages 18 to 24, supplementation with Bone-Up (not placebo) was found to produce statistically significant decreases in markers of bone degradation, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OH-vitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.
For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®
- gelatin caps
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- any 6+ = -12.5%!
- any 7+ = -15%!
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Vitamin K and heart healthExperts are recommending that people do what they can to boost their immune systems to work on their immunity and strengthen their defense mechanisms to better combat infection and spread of this virus.
According to a recent study conducted in partnership with the Cardiovascular Research Institute Maastricht, foods rich in vitamin K have been helpful in the battle, and a deficiency may worsen the symptoms of COVID-19.
This virus is known to cause degradation of elastic fibers in the lungs as well as blood clots, vitamin K has been shown to be helpful in the production of proteins that regulate clotting. As such experts have linked the consumption of foods that are rich in vitamin K to blood vessels, bones, and the lungs.
How to avoid lead poisoning
Although exposure to lead has decreased within the last two decades, it is still a concern and caution is advised, especially for children who have access to toys with lead-based paint or individuals who live in older homes. In some instances, lead can leach from the main water pipes and into the household water supply. If exposed to lead, eating a healthy diet can help reduce its absorption by the body.
When lead is consumed, research shows it can cause learning and behavior problems; as it accumulates, it can cause lasting problems with growth and development. Infants and children are at a higher risk because they absorb lead more quickly than adults, in addition to being more likely to put non-food items that might contain lead in their mouth.
Why are multivitamins important for your health?
Sometimes, when your only source of news is from mainstream media, it seems as if taking nutritional supplements is worse than taking medicines. Nothing could be further from the truth.
Especially multivitamins and fish oil can be your cheapest way to top health in addition to a healthy diet. People following healthy diets, are as rare as diamonds and it most certainly doesn't mean following the latest fad diet where you must buy expensive exotic ingredients to be doing it right.
Sadly this is possible when the general public is not being educated properly. Even our national nutritional council (Voedingscentrum) still keeps spouting how you should be consuming artificial margarine instead of real butter as it 'contains extra vitamin D' while butter from grass-fed cows will contain this naturally.
However, there is one truth that is universally embraced by almost everyone: in order to become healthier one has to consumer larger amounts of vegetables and fruits and less heavily processed foods. The sad truth is how most Dutch citizens don't even ingest 200 grams of vegetables and fruit on a given day, a far cry from the recommended 500 grams never mind the optimal 750 grams that is considered to be ideal when you're striving from longevity.
How to beat andropause, the condition that ails all elderly malesAndropause is a medical condition, similar to the female menopause, that can affect men between the ages of 40 and 65. Men do not have a clear-cut signpost to mark the transition. In women estrogen drops dramatically at menopause, but testosterone levels in men drop very gradually over many years and decades. The bodily changes in andropause occur very gradually in men and may be accompanied by changes in attitudes and moods, fatigue, a loss of energy, sex drive, stamina, and physical agility.
Andropause may be triggered not only by declines in testosterone, but in the "female" hormone estrogen as well.
There is a growing interest, as well as a booming industry, in the use of testosterone therapy for middle-aged and older men. This interest has led to the definition of a new condition, termed 'andropause' implying that this condition is due to falling levels of testosterone. This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence. Is testosterone therapy appropriate for men with symptoms of male menopause? There is no scientific agreement on this topic.
But it stands to reason that hormones should be used only as a last resort since they have serious risks if misused.
Can zinc deficiency cause depression?
The health benefits of zinc include a proper functioning of the immune and digestive systems, controlled diabetes, reduction in stress levels, improved metabolism, and an increased rate of healing for acne and wounds. Also, it is helpful in terms of pregnancy, hair care, eczema, weight loss, night blindness, cold, eye care, appetite loss, and many other conditions.
What is the importance of zinc?
Zinc plays a vital role in protein synthesis and helps regulate the cell production in the immune system of the human body. It is mostly found in the strongest muscles of the body and is found in especially high concentrations in the white and red blood cells, retina, skin, liver, kidneys, bones, and pancreas. The semen and the prostate gland in men also contain significant amounts of zinc.
In the human body, there are more than 300 different enzymes that require zinc to function normally. Researchers believe that 3,000 proteins (out of approximately 100,000) have this vital mineral.
A normal person has two to three grams of zinc at any given time. There are organs in the human body which secrete it, such as the salivary gland, the prostate gland, and the pancreas. Even cells involved in the activity of the immune system secrete zinc. It is used up in various metabolic processes and eliminated through normal excretory and urinary channels, so it needs to be replenished often. If it isn’t, you will begin to suffer from deficiency symptoms.
Can you be addicted to cheese?
A few days ago, a friend challenged me to go vegan for a day! While I've been a lax vegetarian (lax as in sometimes eating fish) for well over 15 years, I've never ever gone further and banned all animal-derived products from my diet. The most obvious ones being dairy and honey.
Of the two, giving up honey makes the most sense, knowing how much work these hard working bees that are in fact, even an endangered species put into making honey. Given how important these adorable little insects are for nearly every plant species that needs pollination, it makes sense to think about building a so-called 'bee hotel' for them when you happen to have a lot of flowers and trees in your garden and aren't afraid of bees.
By chance, this weekend will be devoted to the first 'National Bee counting Day' on which Dutch citizens aree encouraged to count the amount of bees in your garden and if possible, specify which of the 100+ species it may be.
My response to giving up dairy was a lot more visceral! It was more like "you will need to pry it out of my cold dead fingers!"
With 'it' I am referring to most dairy products, with cheese, yoghurt and ice cream as the main comfort foods.
But is addiction to cheese a real thing? Or bread for that matter?
Why is natto a superfood?When you think of Japanese cuisine, fresh, delicate flavours and intricately presented sushi food come to mind. Amidst all this loveliness, gooey, sticky and stinky fermented soybeans seem somewhat out of place.
Called natto, this stinky dish is lesser known in Europe, but some Japanese (sushi) restaurants offer it as part of their menu and some Asian supermarkets stock it as well.
Natto has a long history as a super food. This little-known Eastern health secret has been a staple in the Japanese diet for more than 1,000 years.
Nutritionally, natto does have a lot to offer. A serving provides the same amount of protein as a similar amount of beef, but with fewer calories.
Natto is a fermented soy food with a distinctive, powerful smell that has been described as similar in pungency to fermented ripe cheese. Or worse, like foot odour mixed with paint thinner.
While some love the taste and will eat it on its own, it's often served with condiments such as sliced green onions, wasabi or pickled ginger.
As a dish it often comes wrapped in rice and seaweed. In Japan, many eat natto at breakfast with rice and, sometimes, with mustard, soy sauce, broth, vegetables or a raw egg.
Natto is a food that divides Japan: half of the Japanese population hates it while the other half likes it.
Natto may not sound that appealing if you aren't a fan of funky flavours, but the growing body of research supporting its health benefits certainly is.
A multivitamin a day keeps the doctor awayWith so many supplements available, and a lot of supplement advertisements in sports magazines targeted at athletes, one is rarely seen: ads for a multivitamin and mineral.
When you think about supplements, what are the first thoughts that go through your mind? Whey protein, nitric oxide, creatine, fat burners, or maybe something else? These are the ones that consume the ads.
What if I told you though that the most important supplement that you must have in your arsenal is not on this list? That is your basic multivitamin. From the chewable ones you took as a kid to the ones you have now. Oh, you don't take them? If not, you better change that immediately if you want to meet your fitness goals.
For the human body to complete all the tasks it has in a normal day, it must be given a wide and complex variety of vital nutrients. Becoming deficient in any one of these essential vitamins or minerals causes breakdown of the metabolic pathway that produces optimum efficiency and performance goes down quick. Obviously, this is NOT what you want!
Timing of supplementsWe frequently receive the question whether it really matters when to use a particular supplement.
Most supplements come with instructions to ingest them with a meal. This is in the assumption that meal contain fat, as fat will aid with absorption through the gut wall. Whether or not this can be your first meal of the day, depends on how much fat it contains. Especially fat-soluble vitamins, such as A,D, E and K need fat for proper absorption.
A work-around is to ingest them together with a larger amount of fish or krill oil softgels if your first meal doesn't contain enough fat.
Another reason take supplements with a meal, is that taking it by itself, can cause nausea or discomfort.
Avoid this, or your bones will get weaker!It is often said vegetarianism is a healthy choice when you want to live a long life. But what about bone mineral density?
Apparently, scientists wondered the same thing, so there are several studies in which a vegetarian lifestyle was examined in comparison with a traditional non-vegetarian lifestyle. A higher dietary acid load (caused by greater consumption of acid-forming foods, such as cereals and meat, than of alkali-forming foods, such as fruit and vegetables) is believed to result in bone mineral dissolution and greater bone resorption, which results in the release of carbonate, citrate, calcium, sodium, and potassium.
Hormones and osteoporosisOver and over again, women are warned to start supplementing calcium and take up weight lifting once they are in their 40s as otherwise we will end up with frail bones at old age.
Bone loss in menopause
Osteoporosis is a naturally occurring phenomenon when bones decrease in density, resulting in weakness and a higher likelihood to break.
Anyone can develop osteoporosis, not just women over 50 years but also men (generally over 70) or anyone who's been bedridden for a long time. The scary part is that bone loss happens without noticable symptoms until a bone breaks spontaneously after a fall that normally would only leave bruises.
take 1 capsule three times a day with a meal or as recommended by your qualified healthcare professional.
adult women (especially during menopause)
take 2 capsules three times per day (for a total of 6) with meals to facilitate maximum absorption, or as directed by your qualified healthcare professional.
contains per daily serving (6 capsules)
Vitamin C (calcium ascorbate) 200mg (220% RDI)
vitamine D3 (cholecalciferol) 1000 iu (130% RDI)
vitramin K2 (as MK-7) 45 mcg (40% RDI)
calcium (elemental from StimuCal microcrystalline hydroxyapatite (MCHA) 1000 mg (80 % RDI)
magnesium oxide 500 mg (120% ADH)
zinc (as zinc-L-methionine sulfate) 10 mg (90% RDI)
copper gluconate 1mg (110% RDI)
manganese (as citrate) 1mg (40% RDI)
potassium (citrate) 99mg (2% RDI)
boron (as citrate) 3mg †
RDI = Recommended Daily Intake
† = RDI not established
active ingredients (Microcrystalline Hydroxyapatite, calcium, phosphorous, magnesium, ascorbate, citrate, zinc, boron, copper, manganese, cholecalciferol, menaquinone), filler (cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), capsule (BSE-free bovine gelatin)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, or taking medications (especially warfarin/Coumadin), consult your healthcare professional before using this product.
contains traces of soy
contains no other familiar allergens (wheat, gluten, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
contains gelatin and animal-derived calcium