B5 - Pantethine 60 softgels - metabolite of pantothenic acid | Jarrow Formulas
Jarrow Formulas Pantethine is the stable form of pantetheine, the active form of the vitamin Pantothenic acid (B5). This is the fundamental component of Coenzyme A (CoA) which transports fatty acids into the mitochondria of cells. CoA combines with acetyl groups to form Acetyl CoA, a participant in energy production. It is one of the most important enzymes in the body and is also critical for many other functions ranging from antibody synthesis to maintaining blood sugar levels. The pathway of pantethine is much shorter than pantothenic acid.
Studies show a favourable effect of supplemental pantethine on cholesterol ratio's and levels. Pantethine's primary use is in lowering high cholesterol and triglyceride levels in the blood while increasing the good HDL cholesterol. Pantothenic acid has no such activity.
Pantethine acts by inhibiting cholesterol synthesis and accelerating the use of fat as an energy source. Several studies have shown impressive lipid lowering effects in diabetics, without side effects. Some physicians may recommend Niacin but Niacin impairs insulin action and is unsuitable for diabetics.
• promotes healthy cholesterol levels
• lowers triglycerides and LDL
• as a pantethenic acid (B5) family member it also promotes hair repair and growth
Pantethine is a derivative of vitamin B5 and the stable disulfate form of pantetheine, which provides the active portion of coenzyme A (CoA), a central “carrier” protein in cellular metabolism. The actions of vitamin B5, also known as pantothenic acid, require that a cysteamine molecule containing a free sulfhydryl (SH) group be conjugated to pantothenic acid to create the active form. Pantethine comes ready-made with cysteamine attached and, therefore, is more metabolically active than pantothenic acid.
Pantethine is important in the production of CoA, a necessary cofactor in more than 70 distinct biochemical pathways in the body. These pathways include fatty acid oxidation, carbohydrate metabolism, the synthesis of acetylcholine, and detoxification in the liver. As an immediate precursor to CoA, pantethine may provide benefits not found with pantothenic acid, which requires enzymatic activation.
Coenzyme-A & Lipid Metabolism
The actions of pantethine in promoting proper lipid metabolism have not been fully explained, but influence is clearly exerted upon the enzymes involved in cholesterol synthesis and carbohydrate metabolism, since each coenzyme-A molecule is composed of one- half of a panthethine molecule. Coenzyme-A acts as an acceptor of acetyl groups produced via pyruvate decarboxylation in the mitochondria forming acetyl-CoA. Acetyl-CoA then enters the Krebs Cycle, where it provides the substrate for energy production. Due to this role, acetyl-CoA is essential to the balance between carbohydrate and fat metabolism.
Pantethine also may direct the primary precursor of cholesterol toward beta-oxidation (in which fats are “burned” to produce energy) or into other catabolic, energy-producing cycles. In fact, one theory holds that the catabolic product of pantethine, cystamine, modulates the activity of hepatic acetyl-CoA carboxylase, leading to increased hepatic oxidation of lipids.
Supplementation with pantethine often progressively supports the metabolism of cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol and apolipoprotein B (Apo-B) while leading to support for healthy levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A (Apo-A). In fact, a placebo-controlled study of pantethine in healthy North American subjects published in 2011 found that after 16 weeks of daily use (weeks 1-8 = 600 mg/ day, weeks 9-16 = 900 mg/day) there were significant benefits to cholesterol parameters, including apolipoprotein B.
Detoxification & the Liver
Acetylation reactions and acetyl-CoA play important biochemical roles beyond energy production in the body. As one example, acetylation is a common tool of detoxification machinery that helps metabolize toxins, pollutants, and drug metabolites (collectively: “xenobiotics”) so they can be more readily excreted from the body. Acetylation is often involved in post Phase II detoxification, allowing further modification of the metabolite for ready disposal. One example of this is the fate of glutathione conjugates (common phase II products) that become acetylcysteine conjugates prior to elimination. First, the glycine and glutamate amino acid residues are removed from what was the glutathione molecule, leaving the cysteine residue exposed. At this point, the cysteine residue is acetylated and only then can the whole molecule be excreted.
Adrenals & Stress
Pantothenic acid has long been touted as an “anti-stress” vitamin necessary for proper adrenal functioning. This claim for pantothenic acid rests primarily upon its role in adrenal hormone production, but unfortunately has little clinical trial evidence in support. However, human trials have shown a positive influence on some indicators of adrenal function. For example, when 20 subjects with elevated stress were given pantethine in a specially designed test, analysis of their urine indicated an improvement in adrenal response.
Pantethine is a derivative of vitamin B5. Pantethine supports lipid metabolism through its ability to raise levels of CoA, a cofactor involved in several metabolic pathways including carbohydrate and lipid metabolism. CoA combines with acetyl groups to form Acetyl CoA, a participant in energy production. Pantesin® is a scientifically validated brand of pantethine made by Daiichi Pharmaceutical Co., Ltd. of Japan.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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What causes grey hair? Can it be prevented or treated?
One of the results of a lockdown during the current COVID-19 pandemic was that all hair parlours were closed down and those of us, why rely on their hair being dyed by professional hair stylists, were confronted with their grey hair again.
Which made me want to uncover the various reasons why people get grey hair (in my case it was mostly B12-deficiency and stress) and whether grey hair can be prevented and/or treated.
Hair gets its colour from a type of pigment called melanin. The formation of melanin begins in the fetus. Hair gets two types of pigments: the dark pigments are called eumelanin, and light pigments are called pheomelanin. These two types of melanin pigments blend together to form different types of hair colour. Again, these pigments are positioned properly in the hair follicles. So, when hair starts growing, these pigments are absorbed in the hair to give it a particular colour.
Hair colouration is a systematized process. So, if there is a slight difference in the bodily system, the hair loses its colour which is then called as grey hair. Over the decades, the researchers are working hard to find a real solution for grey hair. Unfortunately, there is no specific remedy yet come out that can provide the ultimate solution against grey hair. On the other hand, people must have a clear understanding on why they get grey hair. It will help them to find out the reasons specific to grey hair. Here are some of the causes of grey hair:
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
take 1 capsule twice a day with with water or acidic fruit juice during a meal or as directed by a qualified physician
contains per daily serving (1 capsule)
pantethine 450 mg †
† = Recommended Daily Intake not established
active ingredient (pantethine), softgel capsule (bovine gelatin, glycerin, purified water), light barrier (natural annatto)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
do not use as a replacement of regular prescription cholesterol lowering drugs unless under supervision of a qualified physician
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)