B12 - Hydroxycobalamin 1mg 60 lozenges | AOR

B12 -  Hydroxycobalamin 1mg 60 lozenges | AORB12 -  Hydroxycobalamin 1mg 60 lozenges | AOR

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Retail price: 39,00
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brand:Advanced Orthomolecular Research
best before:March 2024
diet:vegan, hypo-allergenic
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AOR Hydroxy-B12 1mg - hydroxocobalamin is a unique form of vitamin B12, which is more readily converted into the coenzyme forms than conventional cyanocobalamin. Hydroxocobalamin also readily binds body stores of cyanide, unlike conventional cyanocobalamin., which already includes cyanide in its structure. Hydroxocobalamin can be converted into both adenosyl- or methylcobalamine, which are the two versions of B12 made in the body. This makes hydroxy-B12 an interesting option if you hesitate between the various forms of B12.

who benefits from using B-12?
The largest group that will benefit from supplementing with B12 are vegans and vegetarians who consume no or very small amounts of animal-derived protein.
Furthermore there's a group of people who lack adequate amounts of the so-called 'intrinsic factor' which is essential for B12-absorption in the intestines. This intrinsic factor is made by the stomach. People who produce very little stomach acid or who take medicin that reduce stomach acid production like antacids, which reduces B12-uptake.
Another group are those that are gluten-intolerant but who consume too much gluten, which damages the villi in the gut where B12-absorption takes place.
The major advantage of sublingual tablets is that absorption takes place in the mouth through the mucus of the cheek into the blood vessels, so a lack of intrinsic factor is bypassed, just like with B12-injections.

key benefits
• promotes cardiovascular health
• promotes brain function
• helps rid the body of cyanide
• supports the brain and nervous system
• required for methylation cycles
• readily converted into the coenzyme form

background reading
The Roles of B12
Hydroxy B12 is hydroxocobalamin, an unusual form of vitamin B12. This vitamin is essential for the health of the brain and nervous system, and protects nerves from degeneration. Vitamin B12 is also an important part of the crucial biological pathways known as methylation cycles. The active coenzyme form of B12 that is used by the body is methylcobalamin. The conventional form of supplemental B12 is cyanocobalamin, but this form must be converted into methylcobalamin before the body can use it. Hydroxocobalamin bypasses a step of this conversion, and is therefore more readily turned into an active and useful form.

When cyanide is present
While the majority of people will benefit most from taking methylcobalamin itself, hydroxocobalamin offers unique benefits to individuals who may have cyanide toxicity. Hydroxocobalamin binds cyanide to make it easier for the body to get rid of it, and it also enhances the chemical’s detoxification.

A unique supplement
AOR’s Hydroxocobalamin delivers the essential functions of standard vitamin B12 while at the same time ridding the body of cyanide, all in a convenient and reliable lozenge form.

Better Than Regular B12
Hydroxocobalamin is a unique form of vitamin B12, which is more readily converted into the active coenzyme form than conventional cyanocobalamin. Many vitamins, including B12, are not biologically active in the form in which they are normally found in food. In these cases, the body has to convert a vitamin into its coenzyme form in order for the vitamin to exert its biological function.

The Different Forms of B12
The body uses vitamin B12 in the form of two different coenzymes, each of which plays a different role in the body. Adenosylcobalamin was discovered earlier, and is the better-known of these coenzymes. Methylcobalamin is the other coenzyme form of B12. Methylcobalamin prevents the creeping numbness, dementia, and spongy degeneration of the nerve cells seen in B12 deficiency. Adenosylcobalamin helps the body to process some amino acids, and to form substances used in the body’s energy cycle. One coenzyme can’t substitute for the other, any more than you can use your house keys to start your car.

Different Functions
While a good diet and supplement program usually guarantees the body a generous supply of adenosylcobalamin (unless you have a deadly genetic defect), the same cannot be said of methylcobalamin. While adenosylcobalamin is readily stored up in the liver, methylcobalamin’s job requires that it be free to circulate in body fluids. Because of this, methylcobalamin doesn’t hang around in the body for very long.

Thus, while a person getting enough of the basic vitamin (cobalamin) will always have plenty of adenosylcobalamin, the nervous system has no special store of protective methylcobalamin on which to rely. In fact, the body’s methylcobalamin “fuel tanks” can easily be brought below optimal levels, and the supply is quickly depleted if it is not constantly replenished.

An Easier Conversion
When you take a regular B12 (cyanocobalamin) supplement, the body must first convert its B12 into hydroxocobalamin in order to form the B12 coenzymes. This involves the removal and detoxification of the cyanide molecule, followed by biochemical reduction, and then the enzymatic conversion of the reduced cobalamin into one of two metabolically active coenzyme forms.
By taking a preformed hydroxocobalamin supplement, you can skip over this first biochemical stumbling block, allowing for unhampered formation of adenosylcobalamin and methylcobalamin.

Methylcobalamin or Hydroxocobalamin?
Because the body can interconvert the two B12 coenzymes, and because the body stores adenosylcobalamin but not methylcobalamin, an adequate supply of methylcobalamin usually ensures that you’ll have plenty of adenosylcobalamin, too - but not vice-versa. Because of this fact, and because of the powerful neuroprotective effects of methylcobalamin, a fully-formed methylcobalamin supplement is the best choice for most people.

Hydroxocobalamin and Cyanide Toxicity
One key exception is persons with known or suspected cyanide toxicity, where hydroxocobalamin has a unique role to play. Hydroxocobalamin helps the body to rid itself of cyanide, both by reacting with the toxin to form cyanocobalamin (which can then be excreted) and by enhancing the detoxification of cyanide through its conversion into the less toxic thiocyanate.
In isolated human cells, hydroxocobalamin penetrates cyanide-laden cells and detoxifies the toxin directly. Hydroxocobalamin has a long history of intravenous use for acute, life-threatening cyanide toxicity (such as during industrial disasters) and is approved for this use in many European countries. At lower doses, oral hydroxocobalamin increases the urinary excretion of thiocyanate in laboratory animals fed cyanide-containing diets.
Sublingual hydroxocobalamin, complexed with betacyclodextrin, is an ideal choice for a B12 supplement in persons concerned with chronic, low-level cyanide toxicity.

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brand :
Advanced Orthomolecular Research
best before:
March 2024
  • lozenges
audience :
  • adults
  • vegetarians
  • pets
  • vegan
  • hypo-allergenic
  • 7+ items = -15%
quantity discount:
  • any 2+ = -2.5%!
  • any 3+ = -5%!
  • any 4+ = -7.5%!
  • any 5+ = -10%!
  • any 6+ = -12.5%!
  • any 7+ = -15%!
  • in stock
shipping costs:
  • €4+ (NL) - €7,50+ (EU) - €20+ (world)
  • quantity discount is valid for any combination of products
  • free shipping >€30 (NL) or €5 discount >€30 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

recommended use
Dissolve one lozenge under the tongue daily or as directed by a qualified health care practitioner.

contains per daily serving (1 lozenge)
hydroxycobalamin (hydroxy-B12) 1000 mcg

active ingredient (hydroxycobalamin), anticoagulant (silicon dioxide), sweetener (sorbitol), filler (magnesium stearate)

keep dry and closed at normal room temperature
keep out of reach of young children

safe for pregnant or lactating women

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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