B - Methyl B12 5mg & Methyl Folate 800mcg 60 lozenges | Jarrow Formulas
Jarrow Formulas Methyl-B12 /Methylfolate 5mg Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Methyl-B12 / Methyl folate 5 mg supports brain cells and nervous tissues.highlights
- convenient lozenge form
- Methylcobalamin (Methyl B-12) is the most bio-available and best utilized form of vitamin B-12. Vitamin B-12 helps maintain brain health, vitality, levels of restful sleep and an enhanced mood
- Folate is needed to support cardiovascular and neurologic health and proper cell division
- Pyridoxal 5-Phosphate (P-5-P) Is the co-enzyme form of itamin B6 and is necessary for the metabolism of proteins and amino acids
Methylfolate or 5-MTHF is the most biologically active form of folic acid.
QUATREFOLIC is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of folic acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier.
Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
In the US, folic acid is classified as vitamin B9, in the NLs it used to be classified as vitamin B11
Quatrefolic is a registered trademark of Gnosis S.p.A
An Enhanced B-12 & Methyl Folate Lozenge
The Jarrow Formulas lozenge of Methyl B-12 + Methyl Folate + B6 (P-5-P) combines the more bioavailable and biologically active forms of the vitamins B6, B-12 and folate in one easy-to-take format.
Why B-12 Is Important
Methylcobalamin (methyl B-12) is the most bioavailable and best utilized form of vitamin B-12. It is well retained and is active without the need for conversion by the body, unlike other forms. Clinical studies have documented methyl B-12 efficacy in slowing the effects of aging on nerve tissue. Methyl B-12 also appears to help balance brain chemicals and promote neurotransmitter synthesis to improve communication between nerve cells. Studies also demonstrate B-12’s ability to reduce blood homocysteine levels, a pro-oxidant marker that has been linked to arterial injury and other health concerns. Methyl B-12 may also help with irregular sleep patterns, immune function and promoting normal cell growth. Finally, Methyl B-12 plays a strategic role in the production of oxygen-carrying blood cells.
Enhanced Neurological Activity & Reduced Homocysteine Levels
Only methyl B-12 initiates methylation, a process in which methyl (CH3) groups are donated to the myelin sheath that insulates nerve fibers and regenerates neurons. Methyl B-12 also helps synthesize neurotransmitters (e.g., serotonin, dopamine, norepinephrine).
Via methylation, Methyl B-12 is a catalyst for the conversion of homocysteine to methionine, an essential amino acid. Similarly, it helps remove other toxins (e.g., arsenic) from the body.
Risk Factors for Vitamin B-12 Deficiency
Advancing age, medication, and diet are the primary risk factors for vitamin B-12 deficiency.
It is recommended that people over fifty consider supplements and vitamin B-12-fortified foods. Indeed, up to 40 percent of older individuals suffer from reduced stomach acid, which impairs absorption of protein-bound vitamin B-12. Medications for stomach ulcers, heartburn, or GERD inhibit gastric secretions, and impair vitamin B-12 absorption. Any disorder of the digestive tract may increase the risk for vitamin B-12 deficiency. The best sources of vitamin B-12 are animal products, such as meat, eggs, and fish. Therefore, strict vegetarians (those who eat no animal products) are at considerable risk. One study reported vitamin B-12 deficiency in 58% of vegetarians.
Folate (vitamin B9) deficiency leads to a type of anemia. In the 1960s, scientists further discovered that folate deficiency during pregnancy leads to neural tube defects, such as spina bifida and anencephaly, in newborns. In support of this finding, folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
However, taking folic acid only, especially in the synthetic form, may lead to a more pronounced B12-deficiency, which can lead to other birth defects of their own.
Similarly, folate is needed to support cardiovascular and neurologic health and proper cell division.
Folic Acid versus Folate
Folate is a generic name for a naturally occurring family of compounds containing a pteridine ring linked to p-aminobenzoic acid and containing a polyglutamate tail. The folates found in food consist of a partially bioactive mixture of folate polyglutamates, but these tend to readily degrade during harvesting, storage, and food processing. Up to three-quarters of initial folate activity may be lost. Synthetic folic acid, which is used for fortification, is much more stable because the pteridine ring is not reduced (is in the oxidized state); it also is devoid of the polyglutamate tail.
Concerns have been raised about the potential side effects associated with too much synthetic folic acid intake. In contrast, it is not generally believed that natural folates present such risk even at high levels of intake.
Folate → Dihydrofolate → Tetrahydrofolate ↔ Methylene-THF → Methylfolate (5-MTHF) Bioactive Form
The difference may stem from the biochemical conversion of folic acid to the bioactive form. In humans, the initial reaction is unusually sluggish. It takes place at < 2% the rate as in rats. And just as surprising, the activity of this enzyme can vary amongst humans by 500%. Natural folates, largely avoid this bottleneck since they are already partially on their way toward the bioactive form.
Quatrefolic®- 4th Generation Advantages
Dietary folate easily deteriorates and folic acid is susceptible to bottlenecks and impasses in the conversion to the bioactive form, especially in individuals with certain common genetic variations in metabolism. 5-MTHF itself overcomes one shortcoming by providing the bioactive form. Stabilizing 5-MTHF as the glucosamine salt leads to gains in both stability and bioavailability. Methyl Folate (5-MTHF) is the most biologically active form of folate. Quatrefolic® ((6S)-5-methyltetrahydrofolate glucosamine salt) is the 4th generation development in folate delivery.
Pyridoxal 5-Phosphate (P-5-P)
Pyridoxal 5-Phosphate (P-5-P) is the coenzyme form of vitamin B6 and is necessary for the metabolism of proteins and amino acids. Vitamin B6 is a cofactor in multiple enzyme systems in the body.
P-5-P) assists the reduction of homocysteine to methionine through the cystathionine pathway.
Jarrow Formulas’ Methyl B-12 / Methyl Folate Lozenge
Jarrow Formulas’ Methyl B-12 / Methyl Folate Lozenge provides Methyl B-12, Methyl Folate and Pyridoxal 5-Phosphate in a convenient lozenge form. Methyl B-12 is a readily-absorbed, highly bioavailable form of vitamin B-12 that helps maintain brain-health, vitality, levels of restful sleep and an enhanced mood. It also helps to detoxify homocysteine and other oxidants associated with aging. Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division, especially in those with common genetic variations that limit its biosynthesis. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Feeling sad and stressed due to COVID-lockdown?
Depression in winter time is quite normal, because we aren't exposed to the vitamin D-generating sunrays, which also enhances immunity levels. Fortunately, we can take vitamin D supplements to combat seasonal depression as well as enhance immunity levels.
Another way to chase sadness away is by celebrating, no matter whether that's Sinterklaas, Winter Solstice, Hanukkah, Christmas or New Year. We will decorate our houses, exchange gifts and overeat , get a bit tipsy and enjoy ourselves.
This year is different: restaurants, shops and even gyms need to close down and we are not allowed to gather together in groups. Lack of entertainment, retail therapy and exercise will make it much more difficult to overcome feelings of depression.
It gets worse when you are among those who work in the tourism or entertainment industry and have lost your job as well as most of your income.
For now it is probably best to just accept the current state of affairs and try to console yourself with non-edible goods, such as nice music with a good book, entertaining movie, and aromatherapy (perfume/room fragrances).
And, weather permitting, put on your walking shoes and go for a long walk in the forests or local park.
But perhaps you have been feeling too stressed to enjoy whatever you still can do to relax? Or you were already feeling sad before COVID-19 came along? In that case, DHEA might help.
Set point and holiday weight gain
Low-dose radiation therapyLast week I listened to a Dutch podcast, which in general discusses news and politics, but for once, talked about low-dose radiatian therapy as a way to treat COVID-19. This made me curious enough that I wanted to find out more about this particular treatment method.
Most of us know at least one person, whos's been treated with high-dose radiation order to get rid of a malignant tumor. It is less well known that low dosages can be used as well and is used in some countries to treat inflammation disorders such as arthritis.
In general, this is met with disbelief as the official point of view is "all radiation is harmful" .
Proof to the contrary
Yet, over 3000 scientific research papers show that low dose irradiation is stimulatory and/or beneficial in a wide variety of microbes, plants, invertebrates, and vertebrates.
What causes grey hair? Can it be prevented or treated?
One of the results of a lockdown during the current COVID-19 pandemic was that all hair parlours were closed down and those of us, why rely on their hair being dyed by professional hair stylists, were confronted with their grey hair again.
Which made me want to uncover the various reasons why people get grey hair (in my case it was mostly B12-deficiency and stress) and whether grey hair can be prevented and/or treated.
Hair gets its colour from a type of pigment called melanin. The formation of melanin begins in the fetus. Hair gets two types of pigments: the dark pigments are called eumelanin, and light pigments are called pheomelanin. These two types of melanin pigments blend together to form different types of hair colour. Again, these pigments are positioned properly in the hair follicles. So, when hair starts growing, these pigments are absorbed in the hair to give it a particular colour.
Hair colouration is a systematized process. So, if there is a slight difference in the bodily system, the hair loses its colour which is then called as grey hair. Over the decades, the researchers are working hard to find a real solution for grey hair. Unfortunately, there is no specific remedy yet come out that can provide the ultimate solution against grey hair. On the other hand, people must have a clear understanding on why they get grey hair. It will help them to find out the reasons specific to grey hair. Here are some of the causes of grey hair:
Skin hunger: why we crave touch
As we are in the midst of the Easter Holiday, we can't help but feel sad. While Mother Nature is showing abundant signs of spring during a period of incredibly sunny weather, we are barely allowed to go outside other than to do what is absolutely necessary. Our gyms have been closed for almost a month now while in some countries, people aren't even allowed to exercise. Not just group exercise, but also to just jump on a bike and go for long rides.
While couples and families get grumpy from living together in a cramped space, others face different problems: they are living without any companion whatsoever. Therefore it's not a miracle how all of a sudden, pet asylums have been able to 'clear out' their list of unwanted pets. Not just because people have more time at hand to walk a dog (just about the only thing some are allowed to do) but also because they crave the ability to touch a living being, for lack of being able to touch another human.
Somehow, just like the sense of smell is overlooked, this also is true for the sense of touch. Only when we lose it, we crave it. This craving also is called 'touch hunger' or 'skin hunger'.
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
How do you recognize vitamin B deficiency?
Traditional media often run stories about how supplements may cause problems. One of the problems with studies highlighting supplements is they typically use synthetic vitamins, and not whole food supplements. Your body was not made to process unnatural agents, often posing as equivalents to the real thing. The reality is they are frequently not the same and do not provide you with the same health benefits.
Vitamin deficiencies may lead to illness and disease, and contribute to chronic issues such as high blood pressure, dementia and cancer. One nutritional deficiency having the potential to wreak havoc on your health, your cognition and even your respiratory system is a deficiency in vitamin B complex. B vitamins also help your body to detoxify from chronic exposure to pollutants and chemicals.
Pigmentation spots : why do we get them when we age?Do you sometimes look down onto your arms and notice they are covered with white spots that resemble freckles in reverse?
Especially when arms get tanned in summer, these white spots tend to stand out more than ever.
This led me to the idea to look up what can be a cause of this weird pigmentation.
Mine turns out to be one called idiopathic guttate hypomelanosis (IGH), in other words, an unexplained teardrop-shaped lack of pigmentation, which is apparently very common among most people of over 40 years , but may also happen at a younger age. These white spots appear on the shins, legs, arms, and other sun-exposed areas of the body like the face, neck, and shoulders.
Apparently the body experiences a gradual reduction of melanoyctes and skin cells no longer produce pigment, a similar process that causes the graying of hair. The condition is also increasingly being seen in both sexes and darker skinned individuals with a history of long-term sun exposure, which has lead scientists to believe that excessive sun exposure and sun damage is another cause of these white spots.
They are generally 1 to 3 mm in size and commonly show up on the legs before progressing to other parts of the body.
These white spots are not caused by trauma or infection, nor do they indicate an increased risk of skin cancer.
Hereditary factors may be involved because this skin problem seems to run in families.
IGH is not related to vitiligo, in which melanin-producing cells called melanocytes die or are unable to function properly and no longer form melanin.
Other common causes of skin discolorations are
What determines attractiveness?
It is generally accepted as common knowledge how women will feel more sexually attracted to masculin men, but will take far more factors into account when they select future spouses, for which they prefer reliable men who will help raise her offspring.
Another assumption is how women will feel most attracted to masculin-looking men at the most fertile phase of their cycle.
In a recent study where women were shown masculinized and feminized faces of the same men, it was concluded that apparently there is no distinct phase in a women's cycle when they feel less or more attracted, but a bigger influence was whether or not they were in a phase of their life in which they desired to have kids.
When hearing about this study, I immediately wondered why they didn't mention attractiveness of body odour?
Would masculin men not also smell differently from feminine men? In a similar vein, they could have modulated a man's own smell by adding perfume that is perceived as masculin or feminine.
Whomever has followed threads on any perfume forum or has watched popular perfume reviews on Youtube will know that one of the most often asked questions by young and inexperienced men is, "what fragrance is a 'panty dropper'?" In other words, will this fragrance make me so irresistible that women will want to have sex with me?"
The power of positive thinking
Why is stress so hard on the body?When we are stressed, our bodies produce higher levels of cortisol, a hormone that shuts down the thinking center of our brains and activates conflict aversion and protection behaviors. We become more reactive and sensitive. We often perceive even greater judgment and negativity than actually exists. And these effects can last for 26 hours or more, imprinting the interaction on our memories and magnifying the impact it has on our future behavior. Cortisol can be self-inforcing, the more we think about a stressful event, the bigger and longer the impact.
Positive comments produce a chemical reaction too. They spur the production of oxytocin, a feel-good hormone that elevates our ability to communicate, collaborate and trust others by activating networks in our prefrontal cortex. But oxytocin metabolizes more quickly than cortisol, so its effects are less dramatic and long-lasting.
In order to counterbalance the effect of stress, a much higher amount of positive events must happen, which in the real world, is not so easy to achieve.
Another factor which makes it harder to achieve happiness, is that every individual has a 'happiness set point'.
A happiness set point is the point on a continuum of happiness with which we are born.
In early research it was concluded that positive events (such as winning the lottery) and negative events (such as an accident) change our happiness levels for a short period of time, until after a while, we return to the baseline, our happiness set point.
Lately though it has been shown that we *can* change our setpoint. This however, is not very easy and requires hard work!
So let's look at the factors that can help influence happiness!
Why you should combine B12 with BiofolateJarrow Formulas Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Natural family planningIn the past week another birth control method came under fire for a brief moment: even the intrauterine device (IUD or coil) with the lowest amount of hormones when compared to the birth control PILL, has an oftentimes negative effect all over the body and is not 'just' effective locally. I was like, "duh, what else were you expecting?" .
Afterwards, the news disasppeared rapidly out of the headlines as of course, what else is to the disposition of a fertile woman, who likes to have sex, but doesn't like to get pregnant? A condom!
Indeed, a condom. But what if you have a steady and reliable partner, who isn't likely to get a STD, then it is quite something to always be using 'that' contraption.
Stronger with folic acidFor a very long time already, women that want to get pregnant, are advised to start taking folic acid or biofolate (the preferred form). Like-wise, seniors have started to take it as well, especially in combination with vitamin B12 in order to reduce homocystein levels.
In a new study it was concluded, folates give seniors stronger muscles too!
Big Pharma prevented research into homocysteinMoney-hungry pharmaceutical companies prevented ongoing research into the impoortance of the amino acid homocystein for the development of cardiovascular diseases. The vitamins that can lower homocystein levels are so cheap that it is not possible to make a profit on them. This is what the scientific journalist Emily Yoffe wrote in an older article (2002)
Homocysteine: the real culpritFor the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats and cholesterol in the mid-1950s Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Dissolve in mouth or chew 1 lozenge per day or as directed by your qualified healthcare professional
contains per daily serving (1 lozenge)
vitamin B6 (as pyridoxal 5-phosphate 2.5mg (150% RDI)
methylfolate (QUATREFOLIC® ) 800mcg (200% RDI)
- as (6S)-5-methyltetrahydrofolic acid glucosamine salt
vitamin B12 (as methylcobalamin) 5mg (208 330% RDI)
RDI = Recommended Daily Intake
active ingredients (methylcobalamin, pyridoxal 5-phosphate, methylfolate), sweetener(Xylitol), filler (cellulose, stearic acid from vegetable source), flavour (natural cherry flavor), acidifier (citric acid), sweetener (rebiana stevia extract), filler (magnesium stearate from vegetable source)
keep dry and closed at normal room temperature
keep out of reach of young children
If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans