B - maxMethyl 90 capsules - B6, methyl-B12, folic acid & betaine (TMG) | AOR
AOR maxMethyl contains methyl group (CH3) donors from Methyl B12, TMG and Folic Acid (B11), plus vitamin B6 for additional reduction of homocysteine.
Methyl groups convert homocysteine, a toxic amino acid, into methionine, which is an essential amino acid. Methylation is inhibited by a lack of vitamin B6, B11 (folic acid) and B12 and other factors such as poor diet, smoking and genetic predisposition. Impaired methylation elevates homocysteine levels.
Too high homocystein levels can lead to aggregation of blood platelets to blood clots, which in return damages blood vessels and causes thrombosis.
Methylcobalamin (Methyl B12) is better absorbed, retained and utilized than cyanocobalamin, the typical form of vitamin B12. Methylfolate transfers a methyl group to cobalamin to form Methylcobalamin via the enzyme methionine synthetase. Therefore, Methyl B12 is the most active and most important form of B12.
Methylating agents and co-factors
- Decreases dangerous levels of homocysteine
- Lowers the risk of cardiovascular disease
- Protects against damaged blood vessels
- Slows the aging process
Protect yourself against elevated homocysteine levels
Homocysteine is a toxic amino acid. It is naturally produced in the body as a byproduct of several metabolic pathways, such as the metabolism of the amino acid methionine to produce essential nucleic acids, fats and high-energy bonds. When methionine loses a methyl group, homocysteine is produced. If homocysteine levels increase, blood vessels are damaged and collagen formation is impeded. There are two pathways in the human body that can lead to the elimination of homocysteine: it can be methylated to methionine or condensed into cysteine. The former process requires folate and vitamin B12, while the latter is vitamin B6 dependant.
Why is Homocysteine Harmful?
Elevated blood levels of homocysteine (Hyperhomocysteinemia) have been associated with higher incidences of coronary artery disease and increased risk of mortality from cardiovascular diseases. Hyperhomocysteinemia is an independent factor for peripheral vascular, cerebrovascular and coronary heart disease. High homocysteine levels have a variety of injurious effects and are thought to damage blood vessel walls and lead to cardiovascular complications. Impairment in the conversion of homocysteine to cysteine might also lead to higher blood cholesterol levels because cysteine is required for the metabolism of cholesterol. It is also possible that the amino acid affects blood coagulation.
What causes elevated homocysteine levels?
Elevations can arise from genetic defects, or from poor consumption of nutritional factors involved in homocysteine metabolism, particularly vitamins B12, B6 and folic acid. Insufficient intake of folate, vitamin B12 and B6 are common in the elderly. However, even young, healthy adults who exercise have been found to have elevated levels of homocysteine.
A study of over 1000 people showed that as dietary folate intake decreases, homocysteine level, narrowing of arteries, heart attacks and death due to cardiac disease increase.
- It is estimated that over 40% of the population is not consuming enough folate to keep homocysteine levels low.
- Hyperhomocysteinemia is believed to cause 60% of peripheral vascular disease.
- The Physician’s Health Study showed that men with higher homocysteine levels had a threefold risk of coronary events.
- Elevated homocysteine levels lead to structural defects in collagen and may play a role in osteoporosis. In vitro studies have demonstrated that homocysteine increases the activity of bone breaking cells, leading to bone resorption.
- Folic acid supplementation reduces homocysteine levels even if the individual is not folate deficient. Simple supplementation can reduce mild homocysteine elevation in virtually all cases. Folic acid supplementation is more effective than dietary folate at lowering homocysteine levels.
The ingredient combination included in AOR’s MaxMethyl was tested in a randomized, double-blind, controlled study from the University of East London.
Participants who took this combination had a significant decrease in their homocysteine levels regardless of their initial levels. Those whose initial levels of homocysteine were high enough to put them in the “at risk” category experienced a dramatic homocysteine drop, indicating that these participants reduced their risk of cardiovascular disease in only 6 weeks of supplementation.
How can homocysteine levels be reduced?
The enzymes that metabolize homocysteine into methionine and cysteine use folate, vitamin B12, and vitamin B6 as cofactors. Trimethylglycine is a methyl group donor and has been shown to reduce plasma homocysteine levels by as much as 30%! Trimethylglycine is the most effective homocysteine lowering substance known. AOR’s MaxMethyl has been formulated to include the cofactors and methyl donors necessary for the methylation of homocysteine into other harmless amino acids, and is therefore an effective supplement for the support of cardiovascular health.
For many consumers, methylation products are not well understood in terms of their importance. Methylation is not a process that is talked about in the media or in health circles. However, proper methylation processes are the basis for health in so many areas including joint health, mood, heart disease, and more! Without adequately functioning methylation, aging and disease arrive quickly.
MaxMethyl is formulated to include all the cofactors and methyl donors needed to convert homocysteine into useful amino acids, thereby helping to reduce the risk of heart disease.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
- 9+ items = -20%
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- any 4+ = -7.5%!
- any 5+ = -10%!
- any 6+ = -12.5%!
- any 7+ = -15%!
- any 9+ = -20%!
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Hearing problems and COVID-19: tinnitus explained
Hearing problems and COVID-19
Set point and holiday weight gain
What causes grey hair? Can it be prevented or treated?
One of the results of a lockdown during the current COVID-19 pandemic was that all hair parlours were closed down and those of us, why rely on their hair being dyed by professional hair stylists, were confronted with their grey hair again.
Which made me want to uncover the various reasons why people get grey hair (in my case it was mostly B12-deficiency and stress) and whether grey hair can be prevented and/or treated.
Hair gets its colour from a type of pigment called melanin. The formation of melanin begins in the fetus. Hair gets two types of pigments: the dark pigments are called eumelanin, and light pigments are called pheomelanin. These two types of melanin pigments blend together to form different types of hair colour. Again, these pigments are positioned properly in the hair follicles. So, when hair starts growing, these pigments are absorbed in the hair to give it a particular colour.
Hair colouration is a systematized process. So, if there is a slight difference in the bodily system, the hair loses its colour which is then called as grey hair. Over the decades, the researchers are working hard to find a real solution for grey hair. Unfortunately, there is no specific remedy yet come out that can provide the ultimate solution against grey hair. On the other hand, people must have a clear understanding on why they get grey hair. It will help them to find out the reasons specific to grey hair. Here are some of the causes of grey hair:
Heart disease: what are the differences between men and women?
Past week there was attention for new documentary called "De slag om het vrouwenhart", made by Hella de Jong, in which she relates about her quest for heart health. She suspected health problems, but wasn't sure why. After having been told her problems were psychosomatic, caused by her parents' traumatic WWII experiences, she wasn't satisfied and kept pushing for more research. Finally she got a massive heart attack while perfoming a stress test in the hospital.
This interview sent me on an immediate flashback to 1985, when my mom felt ill enough to visit the hopital after what was probably a minor heart attack. Her complaints weren't taken very seriously, yet they admitted her to hospital, though without being tied to a heart monitor. It was here she died that same day in the presence of my brother. When listening to Hella's story it seems there hasn't changed much in 35 years.
For a very long time, women were not taken into consideration when research was conducted on heart diseasae. Nor were they taken seriously when they went to their doctors with health complaints. Yet, among women, heart disease has also become the leading cause of death.
Determining heart disease risk in women
Women and men share many heart disease risk factors, but recent studies are showing what previous male-focused studies have not shown: Women also have their own unique heart disease risk factors.
Traditional risk factors common to both women and men:
- high blood pressure
- family history
- metabolic syndrome – the co-existence of high blood pressure, obesity, and high glucose and triglyceride levels
- high levels of C-reactive protein – a sign of inflammatory disease that can occur along with other cardiovascular risk factors
Some risk factors that relate specifically to women or that can affect women disproportionately include:
- relatively high testosterone levels prior to menopause
- increasing hypertension during menopause
- autoimmune diseases such as rheumatoid arthritis – more common in women than in men
- stress and depression are more common among women
- low risk factor awareness: lack of recognition of many of the above conditions as risk factors for heart disease is a risk factor in itself
How do you recognize vitamin B deficiency?
Traditional media often run stories about how supplements may cause problems. One of the problems with studies highlighting supplements is they typically use synthetic vitamins, and not whole food supplements. Your body was not made to process unnatural agents, often posing as equivalents to the real thing. The reality is they are frequently not the same and do not provide you with the same health benefits.
Vitamin deficiencies may lead to illness and disease, and contribute to chronic issues such as high blood pressure, dementia and cancer. One nutritional deficiency having the potential to wreak havoc on your health, your cognition and even your respiratory system is a deficiency in vitamin B complex. B vitamins also help your body to detoxify from chronic exposure to pollutants and chemicals.
How to reduce stress with ASMROur brain is programmed to stress us. It does that a lot and on just about any subject. Like a lot of behavioral reactions, stress used to be and still is a survival mechanism that our brain used in order to inject alertness when needed. It’s there so we could harness internal resources and spring into action in a matter of seconds when hunted or hunting.
Fortunately for us, we rarely need to spring into action nowadays to avoid a prowling lion. Today, stress is not helpful and is often counter-productive. When stressed, most of us lose focus and are immersed in unpleasant feelings.
In the past, we needed all that “potential energy” when we faced fight or flight situations. It probably saved our lives more than once. Today, this energy still exists in each of us in certain situations; if it is not discharged via some sort of conduit (either physical or of a more neural nature), it slows us down.
That’s why we need to get creative in the way we release stress. We don’t have time to go on a vacation every week; often we even can’t step away from the almighty computer, tablet, or cell phone.
What determines attractiveness?
It is generally accepted as common knowledge how women will feel more sexually attracted to masculin men, but will take far more factors into account when they select future spouses, for which they prefer reliable men who will help raise her offspring.
Another assumption is how women will feel most attracted to masculin-looking men at the most fertile phase of their cycle.
In a recent study where women were shown masculinized and feminized faces of the same men, it was concluded that apparently there is no distinct phase in a women's cycle when they feel less or more attracted, but a bigger influence was whether or not they were in a phase of their life in which they desired to have kids.
When hearing about this study, I immediately wondered why they didn't mention attractiveness of body odour?
Would masculin men not also smell differently from feminine men? In a similar vein, they could have modulated a man's own smell by adding perfume that is perceived as masculin or feminine.
Whomever has followed threads on any perfume forum or has watched popular perfume reviews on Youtube will know that one of the most often asked questions by young and inexperienced men is, "what fragrance is a 'panty dropper'?" In other words, will this fragrance make me so irresistible that women will want to have sex with me?"
How to cure a hangover
Quite a lot of people wake up the day after a major holiday like the recent King's Day or Liberation Day with a hangover due to imbibing too much alcohol.
The most widespread assumption is that a hangover is caused by not drinking enough water, and therefore those that aren't drunk enough to remember what to do, will drink a few litres of water before going to bed or at least will try to do so the next morning. Other very popular cures are to drink a lot of coffee and eat a hearty egg-based breakfast. Another advice was heard on the radio from a Dutch food blogger who exclaimed how eating toast with honey is a definite cure for hangovers. Around the world a myriad of folk remedies exist for this ancient 'disease'.
Do these remedies actually work and are there some others you didn't think of?
Before we dive into that, let's first discuss the hangover itself.
Why you should combine B12 with BiofolateJarrow Formulas Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Stronger with folic acidFor a very long time already, women that want to get pregnant, are advised to start taking folic acid or biofolate (the preferred form). Like-wise, seniors have started to take it as well, especially in combination with vitamin B12 in order to reduce homocystein levels.
In a new study it was concluded, folates give seniors stronger muscles too!
Big Pharma prevented research into homocysteinMoney-hungry pharmaceutical companies prevented ongoing research into the impoortance of the amino acid homocystein for the development of cardiovascular diseases. The vitamins that can lower homocystein levels are so cheap that it is not possible to make a profit on them. This is what the scientific journalist Emily Yoffe wrote in an older article (2002)
Homocysteine: the real culpritFor the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats and cholesterol in the mid-1950s Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Take 1 capsule three times per day with or without food, or as directed by a qualified health care practitioner.
contains per daily serving (1 capsule)
trimethyl glycine (TMG, anhydrous betaine) 500mg †
vitamin B6 (pyridoxal-5-phosphate) 17mg
folic acid (5-MTHF) 267mcg
vitamin B12 (methylcobalamin) 216mcg
† = Recommended Daily Intake not established
active ingredients (vitamin B6, vitamin B12, folic acid, betaine), filler (microcrystalline cellulose), anti-coagulant (silicon dioxide), capsule (hypromellose)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans