B - maxMethyl 90 capsules - B6, methyl-B12, folic acid & betaine (TMG) | AOR

B - maxMethyl 90 capsules  - B6, methyl-B12, folic acid & betaine (TMG) | AOR

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brand:Advanced Orthomolecular Research
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AOR maxMethyl contains methyl group (CH3) donors from Methyl B12, TMG and Folic Acid (B11), plus vitamin B6 for additional reduction of homocysteine.
Methyl groups convert homocysteine, a toxic amino acid, into methionine, which is an essential amino acid. Methylation is inhibited by a lack of vitamin B6, B11 (folic acid) and B12 and other factors such as poor diet, smoking and genetic predisposition. Impaired methylation elevates homocysteine levels.
Too high homocystein levels can lead to aggregation of blood platelets to blood clots, which in return damages blood vessels and causes thrombosis.

Methylcobalamin (Methyl B12) is better absorbed, retained and utilized than cyanocobalamin, the typical form of vitamin B12. Methylfolate transfers a methyl group to cobalamin to form Methylcobalamin via the enzyme methionine synthetase. Therefore, Methyl B12 is the most active and most important form of B12.

Methylating agents and co-factors

  • Decreases dangerous levels of homocysteine
  • Lowers the risk of cardiovascular disease
  • Protects against damaged blood vessels
  • Slows the aging process

background reading
Protect yourself against elevated homocysteine levels
Homocysteine is a toxic amino acid. It is naturally produced in the body as a byproduct of several metabolic pathways, such as the metabolism of the amino acid methionine to produce essential nucleic acids, fats and high-energy bonds. When methionine loses a methyl group, homocysteine is produced. If homocysteine levels increase, blood vessels are damaged and collagen formation is impeded. There are two pathways in the human body that can lead to the elimination of homocysteine: it can be methylated to methionine or condensed into cysteine. The former process requires folate and vitamin B12, while the latter is vitamin B6 dependant.

Why is Homocysteine Harmful?
Elevated blood levels of homocysteine (Hyperhomocysteinemia) have been associated with higher incidences of coronary artery disease and increased risk of mortality from cardiovascular diseases. Hyperhomocysteinemia is an independent factor for peripheral vascular, cerebrovascular and coronary heart disease. High homocysteine levels have a variety of injurious effects and are thought to damage blood vessel walls and lead to cardiovascular complications. Impairment in the conversion of homocysteine to cysteine might also lead to higher blood cholesterol levels because cysteine is required for the metabolism of cholesterol. It is also possible that the amino acid affects blood coagulation.

What causes elevated homocysteine levels?
Elevations can arise from genetic defects, or from poor consumption of nutritional factors involved in homocysteine metabolism, particularly vitamins B12, B6 and folic acid. Insufficient intake of folate, vitamin B12 and B6 are common in the elderly. However, even young, healthy adults who exercise have been found to have elevated levels of homocysteine.

A study of over 1000 people showed that as dietary folate intake decreases, homocysteine level, narrowing of arteries, heart attacks and death due to cardiac disease increase.

  • It is estimated that over 40% of the population is not consuming enough folate to keep homocysteine levels low.
  • Hyperhomocysteinemia is believed to cause 60% of peripheral vascular disease.
  • The Physician’s Health Study showed that men with higher homocysteine levels had a threefold risk of coronary events.
  • Elevated homocysteine levels lead to structural defects in collagen and may play a role in osteoporosis. In vitro studies have demonstrated that homocysteine increases the activity of bone breaking cells, leading to bone resorption.
  • Folic acid supplementation reduces homocysteine levels even if the individual is not folate deficient. Simple supplementation can reduce mild homocysteine elevation in virtually all cases. Folic acid supplementation is more effective than dietary folate at lowering homocysteine levels.

The ingredient combination included in AOR’s MaxMethyl was tested in a randomized, double-blind, controlled study from the University of East London.
Participants who took this combination had a significant decrease in their homocysteine levels regardless of their initial levels. Those whose initial levels of homocysteine were high enough to put them in the “at risk” category experienced a dramatic homocysteine drop, indicating that these participants reduced their risk of cardiovascular disease in only 6 weeks of supplementation.

How can homocysteine levels be reduced?
The enzymes that metabolize homocysteine into methionine and cysteine use folate, vitamin B12, and vitamin B6 as cofactors. Trimethylglycine is a methyl group donor and has been shown to reduce plasma homocysteine levels by as much as 30%! Trimethylglycine is the most effective homocysteine lowering substance known. AOR’s MaxMethyl has been formulated to include the cofactors and methyl donors necessary for the methylation of homocysteine into other harmless amino acids, and is therefore an effective supplement for the support of cardiovascular health.

Market Trends
For many consumers, methylation products are not well understood in terms of their importance. Methylation is not a process that is talked about in the media or in health circles. However, proper methylation processes are the basis for health in so many areas including joint health, mood, heart disease, and more! Without adequately functioning methylation, aging and disease arrive quickly.

AOR Advantage
MaxMethyl is formulated to include all the cofactors and methyl donors needed to convert homocysteine into useful amino acids, thereby helping to reduce the risk of heart disease.

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Advanced Orthomolecular Research
  • v-capsules
audience :
  • senior
  • vegetarians
  • vegan
  • hypo-allergenic
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  • free shipping >€30 (NL) or €5 discount >€30 (EU)
  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

recommended use
Take 1 capsule three times per day with or without food, or as directed by a qualified health care practitioner.

contains per daily serving (1 capsule)
trimethyl glycine (TMG, anhydrous betaine) 500mg †
vitamin B6 (pyridoxal-5-phosphate) 17mg
folic acid (5-MTHF) 267mcg
vitamin B12 (methylcobalamin) 216mcg

† = Recommended Daily Intake not established

active ingredients (vitamin B6, vitamin B12, folic acid, betaine), filler (microcrystalline cellulose), anti-coagulant (silicon dioxide), capsule (hypromellose)

keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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