Alpha Lipoic Sustain 300mg 120 tablets - sustained release alpha lipoic acid and biotin | Jarrow Formulas
Jarrow Formulas Alpha Lipoic Sustain 300mg 120 tablets is a unique lipid and water soluble antioxidant that is a co-factor in energy production, helping to regulate glucose metabolism. ALA also promotes the synthesis of glutathione. Biotin is added for optimum ALA activity.
Alpha Lipoic Sustain 300 is available as a sustained release format so as to minimize gastric irritations and blood sugar fluctuations. Alpha Lipoic Acid is a disulfide molecule (containing two thiol groups). A thiol (or -SH) consists of a sulfur and a hydrogen atom. This unique anti-oxidant is both lipid- and water-soluble, a potent promoter of glutathione synthesis and a co-factor in energy production, helping to regulate glucose metabolism. Jarrow Formulas Alpha Lipoic Acid is made in Europe. Biotin is added for optimum ALA activity.
Alpha Lipoic Acid is the most abundant anti-oxidant produced in the liver, which serves as a liver detoxifying agent combined with N-Acetyl Cysteine to cleanse the liver by increasing Glutathione production in the liver .
It is frequently stated that that the R- form of alpha lipoic acid is better and more stable than the mixed form. These claims have NOT been verified by other studies other than the one present by marketeers of R-ALA supplements and the respective manufacturers of R-ALA. All of the peer reviewed studies done on ALA have been done with the mix form NOT the R-ALA form which is not stable enough during production.
• helps to control blood sugar levels and lowers dependence on insulin
• reduces abdominal body fat in overweight men and women
• controls carb cravings
• safe to use for a prolonged period
What is Alpha Lipoic Acid?
Alpha lipoic acid (aka ALA, lipoate, thioctic acid, dihydrolipoic acid) is an antioxidant and co-factor in glycolysis. Glycolysis is the initial process in most of the body’s pathways to breakdown glucose into useful forms of energy. Though critical to oxygen utilizing life, ALA is not a vitamin because it can be synthesized from essential fatty acids and the amino acid L-cysteine. However, no food is rich enough to serve as a good source.
Chemically, ALA has two juxtaposed sulfur atoms. When oxidized, the two sulfurs bond together (disulfide form). When reduced to dihydro-lipoic acid, each sulfur atom attaches to hydrogen (thiol form). ALA’s antioxidant chemistry is similar to glutathione, another sulfur-containing molecule and the most abundant antioxidant inside cells.
The Universal Antioxidant
ALA is reduced to its active form, dihydrolipoic acid, inside cells as the body needs it and is able to do so. The enzyme responsible for this, dihydrolipoamide dehydrogenase (LipHD), preferentially reduces the R-enantiomer of lipoic acid; this is why the R form is often considered the only biologically relevant form. However this may not be entirely accurate. Like vitamin C, ALA functions in water-based phases such as blood. However, like vitamin E, it also protects fatty tissues and membranes. ALA quenches free radicals— like hydroxyl, singlet-oxygen, and peroxynitrite—in both water and lipid phases, and protects against lipid peroxidation. It deactivates an unusually wide array of cell-damaging free radicals in many bodily systems.
Recycler Built for Two
ALA also enhances the potency of other antioxidants in both water- based (blood, cytosol) and lipid (membrane, blood fat) compartments. It recycles vitamin C directly and vitamin E indirectly in a unique and significant capacity, often preventing the symptoms of deficiency of these two critical vitamins.
Importantly, ALA increases glutathione levels in cells, in part by facilitating L-cysteine availability. It maintains the ratio of reduced-to- oxidized coenzyme Q10, which impacts mitochondrial health and energy production.
Blood Sugar Metabolism and Muscular Energy
Perhaps the most significant function of ALA is its important role in energy production from carbohydrates, participating in the multi-enzyme process on many levels. ALA stimulates insulin activity, reduces insulin resistance, and enhances glucose burning in obese laboratory animals. Humans with diabetes show a ~50% increase in glucose consumption. This also has implications for athletes and the overweight. Muscle activity requires efficient sugar metabolism. Similar improvements in sugar disposal occurred in brain tissue.
Alpha-lipoic acid is currently being studied for many age-related conditions, including heart and vascular health, sugar balance, neurological function, immune function, as well as fatigue and muscle strength. There is much protective promise in this powerful, broad- spectrum antioxidant.
Special Delivery Requirements—Maximum Benefits
Jarrow Formulas Alpha Lipoic Sustain® 300 is a bilayer Quick Release/Sustained Release ALA formulation. It maximizes blood levels while minimizing gastric irritation and blood sugar fluctuations. One- third of the ALA is releases rapidly and two-thirds releases slowly over time. This raises blood levels quickly while sustaining them. ALA does not accumulate in tissues, so it has no toxicity in suggested amounts. With wide distribution throughout the body, it is used in many ways. ALA finds particular utility in the eyes and brain, with neuroprotective and possibly cognitive-enhancing effects, especially in combination with acetyl-L-carnitine. It also has potential to reduce mercury retention.
Protection is highly dependent upon the dosing regimen. ALA is rapidly cleared from blood by the liver, so it is best supplemented in multiple, divided doses. Clinical studies typically employ 300 mg taken twice daily. Pharmaceutically designed Alpha Lipoic Sustain 300 keeps ALA in circulation for much longer periods than the usual tablet or capsule delivery. Sustained release may also help avoid stomach irritation experienced by sensitive individuals.
Note : Individuals who are diabetic, being treated for glucose control, pregnant or lactating should consult a health care professional before using this product.
The Importance of Biotin
Since biotin and ALA are similar, and transported by the same mechanism, elevated dietary ALA can interfere with biotin absorption and coenzyme functions. To protect against biotin deficiency, Alpha Lipoic Sustain 300 contains over 100% of the recommended daily allowance for biotin.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
- books, probiotics and products bought in the SALE can NOT be returned
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
Why celebrating life with food is important for our health
Especially in the darkest months of the year, there seems to be an endless amount of celebrations.
No matter what is always a common theme: food is the main attraction! In fact, the focus society currently places on food has caused us to associate certain foods with holidays, past events and special times. When we sink our teeth into such foods, it can bring back memories we hold close and take us back to a time we enjoyed. Food is much more powerful than we think!
From catching up for coffee, relaxing over brunch, indulging in a long lunch or bonding at a BBQ, it’s hard to imagine getting together without the company of food. Food is something we all have in common, we all must eat, most of us find food pleasurable and trying new foods or cafes is a new experience we can share with others.
PFAS pollutants causing turmoil
In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.
Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.
If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.
Why is glutathione so important for your health?
Glutathione is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, glutathione is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine.
There are a number of reasons why your body’s glutathione level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age.
Maintaining adequate levels of this antioxidant is incredibly important. Below are some of the best ways to increase your glutathione levels naturally.
Why is it so hard for a diabetic to keep blood sugar levels stable?
Most of you will know how food containing starches or sugars will raise blood sugar levels, and those of us who are dependent on insulin to control blood sugar levels, either because they are born with diabetes (type 1) or develop it later in life (type 2), are keen on keeping their blood sugar levels within a certain range.
This isn't always easy, even when ingesting a precalculated amount of carbohydrates.
There are several reasons why blood sugar levels can fluctuate
Why do we celebrate carnival?Now we are in the midst of Carnival, it made sense to me as a true Southerner to explain the phenomenon to those who don't have an idea where it is all about.
Canival is celebrated in the period preceding Lent, mostly starting on Saturday and finishing on Shrove Tuesday, which is also known as Fat Tuesday or Mardi Gras, because it is the last day on which you can still indulge in fattening foods and alcohol.
The highlight of the carnival is the Sunday parade, for which floats are towed through the streets on which people are all dressed up, oftentimes wearing very intricate costumes. In my home region of Noord-Brabant, a lot of floats would mock local as well as national political issues.
From the anthropological point of view, carnival is a reversal ritual, in which social roles are reversed and norms about desired behavior are suspended. By wearing masks and costumes, it is much easier to make sure this happens and people also experience a heightened sense of social unity.
For those that are most actively involved in carnival, the actual season starts on November 11, the date when the council of Eleven (Elferrat) is chosen. That day is chosen not so much because it is the 'fools number' day, but because November 11 is 40 days before December 21 or midwinter.
While almost everyone knows what Carnival involves, very few actually know what Lent is. If you are among them, you are not the only one.
Lent is the short form of an old English and current Dutch word for spring and is probably also related to the word 'lengthening' (of days in spring).
For Christians, and specifically Catholics, Lent is the practice of fasting observed in the period before Easter.
Fasting is a loosely interpreted term here as it mostly doesn't involve complete abstinence from food, but instead of giving up indulgences for the period of Lent. Some give up on everything considered 'sinful' and others promise to give up one specific vice for Lent, such as alcohol, tobacco, candy, junkfood, sex or more recently also abstinence from social media like Facebook, Twitter or Instagram.
It is these habits that are increasingly also adopted by non-religious people, oftentimes also synchronized with friends who fast for religious reasons.
How reliable is the Glycemic index?Almost everyone who's ever started a diet in the past decade, will have heard about the glycemic index (GI) and have been advised to eat predominantly foods that have a lower glycemic response, that is, foods that will not increase blood sugar level so much.
A high blood sugar level is closely associated with health problems such as diabetes and obesity, and it's easy to measure using a continuous glucose monitor.
A standard developed decades ago, called the glycemic index (GI), is used to rank foods based on how they affect blood sugar level and is a factor used by doctors and nutritionists to develop healthy diets. However, this system was based on studies that average how small groups of people responded to various foods.
This method of the glycemic index (GI) was developed at the University of Sydney where the glycemic response to foods were compared with those of glucose after an overnight fast.
The emphasis on the glycemic index led to an oversimplification of food items as being 'good' or 'wrong' based on their GI-ratings. It can even falsely portray unhealthy foods as “safe.”
Frequently agave syrup and coconut sugar are being advertised as “healthy” because of their low glycemic indexes, yet they lack nutrients such as fiber and vitamins and are nothing but 'empty sugar'.
A bigger problem with the glycemic index is that glycemic responses to foods are highly individual.
While the University of Sidney did their research on just 10 persons, a study with no less than 800 healthy and pre-diabetic volunteers, whose blood glucose levels were monitored every five minutes for a prolonged period of time, a startling difference between individual response on specific foods were shown.
How to eliminate toxins?A while ago, there was a major uproar in the Dutch media about an advice given by a celeb health enthusiast to drink a glass of water with clay in order to 'detox' the body.
Unfortunately, while it is true that clay can bind to toxins, clay is not the best choice for two reasons. The clay itself can be polluted, but moreso, clay isn't the best option.
Balancing your blood sugar level
While it is fairly easy to spot hypoglycemia from shaky hands, acute headaches and listlessness, it is not so easy for hyperglycemia, unless your blood sugar reaches a dangerously high level. Then you may experience the same symptoms such as listlessness but also excessive thirst and blurry eye vision.
take 1-2 tablets a day, preferably with a meal and a glass of water or an acidic fruit juice , or as advised by a qualified physician
contains per daily serving (1 tablet)
Alfa Lipoic Acid 300 mg†
Biotin 333 mcg (100 % RDI)
RDI = Recommended Daily Intake
† = RDI not established
active ingredient (alpha lipoic acid, biotin), fillers (microcrystalline cellulose, vegetable magnesium stearate), anticoagulant (silicon dioxide), coating (hydroxypropylmethylcellulose)
keep dry and closed at normal room temperature
keep out of reach of young children
do not take if pregnant or lactating unless under guidance of a qualified physician
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans