Alpha Lipoic Acid (R+) 60 capsules - R-alpha lipoic acid and biotin | Jarrow Formulas
Jarrow Formulas R-Alpha Lipoic Acid w biotin is a unique lipid and water soluble antioxidant that is a co-factor in energy production, helping to regulate glucose metabolism. ALA also promotes the synthesis of glutathione. Biotin is added for optimum ALA activity.
R-Alpha Lipoic Acid is a disulfide molecule (containing two thiol groups). A thiol (or -SH) consists of a sulfur and a hydrogen atom. This unique anti-oxidant is both lipid- and water-soluble, a potent promotor of glutathione synthesis and a co-factor in energy production, helping to regulate glucose metabolism. Biotin is added for optimum ALA activity.
Alpha Lipoic Acid is the most abundant anti-oxidant produced in the liver, which serves as a liver detoxifying agent combined with N-Acetyl Cysteine to cleanse the liver by increasing Glutathione production in the liver .
who can benefit from R-Alpha Lipoic Acid?
Adults who are interested in enhancing energy production, sugar and lipid metabolism, and antioxidant protection.
what distinguishes R-Alpha Lipoic Acid
• helps to control blood sugar levels and lowers dependence on insulin
• reduces abdominal body fat in overweight men and women
• controls carb cravings
• safe to use for a prolonged period
• the only natural occurring form of alpha lipoic acid: now also heat and shelf stable
• high bioavailability
• the universal antioxidant + biotin in 1 capsule
R-Alpha Lipoic Acid: natural form of alpha lipoic acid
Most alpha lipoic acid (ALA) products contain a racemic mixture of R-Alpha Lipoic Acid (R-ALA) and S-Alpha Lipoic Acid (S-ALA). Generally, equal amounts of R- and S- forms are produced during the chemical synthesis of alpha lipoic acid, and thus, these products contain R-ALA and S-ALA in an equal ratio of 1:1. However, R-ALA is the only form of lipoic acid that is endogenously synthesized in humans and other organisms. Human pharmacokinetic studies have shown that peak concentrations of R-ALA are 40-50% higher than S-ALA after oral supplementation of racemic preparations, suggesting that R-ALA may have better absorption and bioavailability. In animal studies, R-ALA supplementation has shown better biological effects such as insulin-stimulated glucose transport and metabolism, and antioxidative status. Thus, R-ALA may provide superior health benefits compared to racemic mixtures (R-ALA and S-ALA) or S-ALA alone.
Energy production and glucose and lipid metabolism
One of the major functions of R-ALA is to enhance energy production via improved mitochondrial functions. R-ALA is a disulfide compound and it is naturally found in mitochondria as a coenzyme for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, directly helping mitochondrial energy production. It also helps mitochondria as an efficient antioxidant by reducing oxidative stress that may impair or slow down mitochondria. Further, R-ALA is known to stimulate healthy glucose metabolism. In clinical studies, supplementation significantly improved blood glucose levels and insulin activity and sensitivity without any side effects. In these subjects, the incidences of impaired sugar metabolism and associated conditions were considerably reduced. This efficient glucose metabolism seems to contribute to healthy lipid metabolism as well.
R-ALA works in many ways to enhance cellular antioxidant status. For example, supplementation of lipoic acid significantly increases biosynthesis of glutathione, a potent antioxidant that protects cells from reactive oxygen species. In vitro studies have shown that lipoic acid stimulates the expression of gamma-glutamylcysteine ligase, the rate limiting enzyme in the glutathione synthesis pathway, as well as cellular uptake of cysteine, an amino acid required for glutathione synthesis, resulting in an overall increase in intracellular glutathione by 30-70%.
Some of the R-ALA absorbed from the diet or synthesized in the body can be reduced into DHLA (dihydrolipoic acid), an active antioxidative form of R-ALA. Studies have shown that DHLA plays a key role in recycling many antioxidants including vitamins and other molecules involved in various redox systems. For example, it has been reported that DHLA is superior in its ability to regenerate vitamin C from its oxidized form compared to glutathione. DHLA can also reduce alphatocopherols directly or do so indirectly by reducing vitamin C, which then reduces oxidized alpha-tocopherol. Similarly, DHLA reduces oxidized glutathione and prevents lipid peroxidation. These recycled antioxidants, such as vitamin C and glutathione, can further recycle other antioxidants such as vitamin E, keeping the “antioxidant network” active. Lastly, DHLA interacts with NADPH- or NADHdependent electron transport systems to recycle vitamin E.
Inducer of phase II detoxification enzymes
R-ALA also stimulates expression of various phase II detoxification enzyme genes. For example, cells that were treated with lipoic acid showed a dose- and time-dependent increase in gene expression of GSTA2, Glutathione S-transferase A2, a phase II detoxification enzyme that plays a role in elimination of electrophilic toxins such as carcinogens, drugs, environmental toxins and products of oxidative stress. Activation of phosphatidylinositol 3-kinase (PI3K)-dependent CCAAT/enhancer binding protein (C/EBP) has been suggested as one of the possible mechanisms of induced phase II detoxification enzyme expression. Similarly, multiple studies have shown that supplementation of lipoic acid induces neuroprotective phase II detoxification enzymes, NAD(P)H:quinone oxidoreductase (NQO1) and glutathione-S-transferase (GST) in cultured neuronal cells (e.g. human neuroblastoma SH-SY5Y, and C6 astroglial cells) in a doseand time-dependent manner. Treatment also increased endogenous antioxidants, providing additional neuroprotective effects. Therefore, R-ALA supplementation may protect cells from various types of damage by efficiently eliminating toxins and unwanted materials
Biotin supplementation and its significance
Biotin (B7) is a water soluble B-complex vitamin and serves as a cofactor for many enzymes including pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase. These enzymes play critical roles in mammalian gluconeogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine. Thus, biotin supplementation, along with R-ALA, will further support healthy metabolism and energy production.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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PFAS pollutants causing turmoil
In October, nearly every construction project came to a grinding halt in the Netherlands, because not a single project except the smallest ones can be completed without excessive paper work or laboratory tests.
Why? The current legal threshold for PFAS, an abbreviation for perfluorinated alkylated substances has been set extremely low until the government is able to define a proper health limit for contaminated soil so as to prevent contamination of clean soil with more heavily contaminated soil.
If cemeteries hadn't been exempt from the rule, not a single dead body could have been interred, since PFAS-chemicals , also known as 'forever chemicals' have accumulated in our bodies to an extent that exceeds the legally set threshold, which is currently as low as the lowest possible detection level.
Why is glutathione so important for your health?
Glutathione is one of the body’s most important and potent antioxidants. Antioxidants are substances that reduce oxidative stress by combating free radicals in the body.
While most antioxidants are found in the foods you eat, glutathione is produced by your body. It is primarily made up of three amino acids: glutamine, glycine and cysteine.
There are a number of reasons why your body’s glutathione level may become depleted, including poor diet, chronic disease, infection and constant stress.
Glutathione is also known to decrease with age.
Maintaining adequate levels of this antioxidant is incredibly important. Below are some of the best ways to increase your glutathione levels naturally.
Why is it so hard for a diabetic to keep blood sugar levels stable?
Most of you will know how food containing starches or sugars will raise blood sugar levels, and those of us who are dependent on insulin to control blood sugar levels, either because they are born with diabetes (type 1) or develop it later in life (type 2), are keen on keeping their blood sugar levels within a certain range.
This isn't always easy, even when ingesting a precalculated amount of carbohydrates.
There are several reasons why blood sugar levels can fluctuate
Why do we celebrate carnival?Now we are in the midst of Carnival, it made sense to me as a true Southerner to explain the phenomenon to those who don't have an idea where it is all about.
Canival is celebrated in the period preceding Lent, mostly starting on Saturday and finishing on Shrove Tuesday, which is also known as Fat Tuesday or Mardi Gras, because it is the last day on which you can still indulge in fattening foods and alcohol.
The highlight of the carnival is the Sunday parade, for which floats are towed through the streets on which people are all dressed up, oftentimes wearing very intricate costumes. In my home region of Noord-Brabant, a lot of floats would mock local as well as national political issues.
From the anthropological point of view, carnival is a reversal ritual, in which social roles are reversed and norms about desired behavior are suspended. By wearing masks and costumes, it is much easier to make sure this happens and people also experience a heightened sense of social unity.
For those that are most actively involved in carnival, the actual season starts on November 11, the date when the council of Eleven (Elferrat) is chosen. That day is chosen not so much because it is the 'fools number' day, but because November 11 is 40 days before December 21 or midwinter.
While almost everyone knows what Carnival involves, very few actually know what Lent is. If you are among them, you are not the only one.
Lent is the short form of an old English and current Dutch word for spring and is probably also related to the word 'lengthening' (of days in spring).
For Christians, and specifically Catholics, Lent is the practice of fasting observed in the period before Easter.
Fasting is a loosely interpreted term here as it mostly doesn't involve complete abstinence from food, but instead of giving up indulgences for the period of Lent. Some give up on everything considered 'sinful' and others promise to give up one specific vice for Lent, such as alcohol, tobacco, candy, junkfood, sex or more recently also abstinence from social media like Facebook, Twitter or Instagram.
It is these habits that are increasingly also adopted by non-religious people, oftentimes also synchronized with friends who fast for religious reasons.
How reliable is the Glycemic index?Almost everyone who's ever started a diet in the past decade, will have heard about the glycemic index (GI) and have been advised to eat predominantly foods that have a lower glycemic response, that is, foods that will not increase blood sugar level so much.
A high blood sugar level is closely associated with health problems such as diabetes and obesity, and it's easy to measure using a continuous glucose monitor.
A standard developed decades ago, called the glycemic index (GI), is used to rank foods based on how they affect blood sugar level and is a factor used by doctors and nutritionists to develop healthy diets. However, this system was based on studies that average how small groups of people responded to various foods.
This method of the glycemic index (GI) was developed at the University of Sydney where the glycemic response to foods were compared with those of glucose after an overnight fast.
The emphasis on the glycemic index led to an oversimplification of food items as being 'good' or 'wrong' based on their GI-ratings. It can even falsely portray unhealthy foods as “safe.”
Frequently agave syrup and coconut sugar are being advertised as “healthy” because of their low glycemic indexes, yet they lack nutrients such as fiber and vitamins and are nothing but 'empty sugar'.
A bigger problem with the glycemic index is that glycemic responses to foods are highly individual.
While the University of Sidney did their research on just 10 persons, a study with no less than 800 healthy and pre-diabetic volunteers, whose blood glucose levels were monitored every five minutes for a prolonged period of time, a startling difference between individual response on specific foods were shown.
Is Alzheimer’s Disease the same as type 3 diabetes?Alzheimer starves your brain, tangles and twists vital cells, and for decades it has been misrepresented as an untreatable, genetically determined disease. Alzheimer's disease is already an important cause of death in Western Europe and is expected to rise to the top. This devastating illness shares a strong link with another sickness that wreaks havoc on millions of people too: diabetes.
Sugar = sugar?!While baking recipes used to simply recommend using flour and sugar, the hip cookbooks now recommend you to use agave syrup, or coconut sugar , because it is healthier and more natural. It sure sounds like more natural, but is it really?
How to eliminate toxins?A while ago, there was a major uproar in the Dutch media about an advice given by a celeb health enthusiast to drink a glass of water with clay in order to 'detox' the body.
Unfortunately, while it is true that clay can bind to toxins, clay is not the best choice for two reasons. The clay itself can be polluted, but moreso, clay isn't the best option.
Balancing your blood sugar level
While it is fairly easy to spot hypoglycemia from shaky hands, acute headaches and listlessness, it is not so easy for hyperglycemia, unless your blood sugar reaches a dangerously high level. Then you may experience the same symptoms such as listlessness but also excessive thirst and blurry eye vision.
take 1 capsule per day or as directed by your qualified health care consultant
contains per daily serving (1 capsule)
R-Alfa Lipoic Acid 100 mg†*
biotin 150 mcg (50 % RDI)
RDI = Recommended Daily Intake
† = RDI not established
* 100mg R-alpha lipoic acid equals 200mg LR-alpha lipoic acid
active ingredient (R-alpha lipoic acid, biotin), fillers (cellulose, magnesium stearate from palm oil), anticoagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)
keep dry and closed at normal room temperature between 15 - 22°C
keep out of reach of young children
If you have a medical condition (especially diabetes or are being treated for glucose control), are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially for glucose control), consult your health care practitioner before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans