AOR Advanced Fibromyalgia Support helps relieve symptoms of fibromyalgia, promotes healthy mood and helps reduce the severity and duration of migraine headaches when taken as a prophylactic.
Advanced Fibromyalgia Support also contains carbohydrates to support energy production, endurance and performance during extended intensity exercise.
key benefits of Advanced Fibromyalgia Support
• contains the 3 most effective ingredients for fibromyalgia
• relieves pain and fatigue
• supports mood balance
• provides high doses for maximum effect
The primary symptom of fibromyalgia is muscle pain, although it is often accompanied by fatigue, mood changes, sleep difficulties and memory problems.
The cause is often unclear, but several nutrients have shown good success in improving its symptoms.
Advanced Fibromyalgia Support is the first fibromyalgia product to provide high doses of several of the most effective and commonly used supplements to help reduce the symptoms of fibromyalgia, including d-ribose, magnesium malate and 5-HTP.
Advanced Fibromyalgia Support is in powder form, making it easier to get effective doses of each ingredient. Advanced Fibromyalgia Support is designed to improve quality of life by reducing muscle pain, improving mood and sleep, and increasing energy.
The compound found most effective and best tolerated is 5-HTP. With 5-HTP, people have reported better mood, better sleep and less pain with 100-300 mg a day.
Magnesium reduces muscle pain, cramps and brain fog, and helps with sleep, while malic acid improves energy production.
D-Ribose increases energy, reduces post-exercise pain, reduces brain fog and fatigue, and improves sleep.
People have also reported fewer knots and trigger points in their muscles.
Low Magnesium Levels Contribute to Symptoms of Fibromyalgia
Fibromyalgia patients often show normal calcium and magnesium serum levels. However, researchers were convinced that magnesium was somehow involved in fibromyalgia.
Several studies have now investigated magnesium content in various cells rather than in the blood since very little magnesium is found in the blood in the first place, but is stored in tissues such as bone (therefore, blood tests are not an accurate measure).
One study showed high intracellular calcium and low intracellular magnesium in fibromyalgia patients. A hair mineral analysis of fibromyalgia patients showed low magnesium levels, while a serum test did not.
In an exercise-based study, fibromyalgia patients had lower free magnesium, magnesium-ATP and total ATP during knee extension endurance exercise than controls. This correlated with increased muscle weakness, which is characteristic of fibromyalgia patients.
A study investigating the relationship between magnesium levels and fibromyalgia symptoms used magnesium citrate treatment for the relief of symptoms. The study involved 60 pre-menopausal women diagnosed with fibromyalgia, and 20 healthy pre-menopausal women matched for age and weight.
The fibromyalgia patients were divided into three groups. The magnesium citrate (300 mg/day) was given to the first group, amitriptyline (10 mg/day) (a tricyclic antidepressant, the most commonly prescribed medication for fibromyalgia) was given to the second group, and magnesium citrate (300 mg/day) + amitriptyline (10 mg/day) treatment was given to the third group for 8 weeks.
The serum and erythrocyte magnesium levels were significantly lower in patients with fibromyalgia than in the controls.
Also there was a negative correlation between the magnesium levels and fibromyalgia symptoms. The number of tender points, tender point index, the Fibromyalgia Impact Questionnaire and (Beck) depression scores decreased significantly with the magnesium citrate treatment.
The combined amitriptyline + magnesium citrate treatment proved effective on all parameters except numbness.
The study concluded that low magnesium levels in the erythrocyte might be a factor in the development of fibromyalgia symptoms.
Magnesium Malate for Fibromyalgia Symptoms
In a randomized, placebo-controlled study in twenty-four patients with primary fibromyalgia, 3 tablets twice a day of Super Malic were administered for 4 weeks, followed by a 6-month, open study where the dose was gradually increased up to 6 tablets twice daily.
Each tablet contained 200 mg of malic acid and 50 mg of magnesium.
During the 6-month follow up, significant reductions in the severity of all 3 primary pain/tenderness measures were obtained without limiting risks.
D-Ribose for Increasing Energy Levels and Improving Fibromyalgia
41 patients with a diagnosis of fibromyalgia and/or Chronic Fatigue Syndrome were given D-ribose, a naturally occurring pentose carbohydrate, at a dose of 5 g three times a day for a total of 280 g.
D-ribose, which was well-tolerated, resulted in a significant improvement in all five visual analog scale (VAS) categories: energy, sleep, mental clarity, pain intensity, and well-being, as well as an improvement in patients’ global assessment.
Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30%. D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.
5-HTP Provides Significant Clinical Improvements
A double-blind, placebo-controlled study of the benefits and tolerability of 5-hydroxytryptophan (5-HTP) was conducted in 50 patients with primary fibromyalgia syndrome in an open 90-day study.
All of the clinical parameters studied were significantly improved by treatment with 5-HTP with minimal side-effects reported.
The overall evaluation of the patient condition assessed by the patient and the investigator indicated a ‘good’ or ‘fair’ clinical improvement in nearly 50% of the patients during the treatment period.
Clinical variables studied throughout the trial included number of tender points, anxiety, pain intensity, quality of sleep and fatigue.
The study concluded that 5-HTP is effective in improving the symptoms of primary fibromyalgia syndrome and that it maintains its efficacy throughout the 90-day period of treatment.
Evidence from multiple studies support the idea of decreased activity through the serotonin pathway in fibromyalgia patients.
Serotonin supplementation, by using L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patients. Identification of low serum tryptophan and serotonin levels may be a practical method to identify persons who will respond well to this approach.
5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. In the CNS, serotonin levels have been implicated in the regulation of sleep, mood, aggression, appetite, temperature, sexual behaviour, and pain sensation.
Therapeutic administration of 5-HTP has been shown effective in treating a wide variety of conditions, including mood imbalances, fibromyalgia, binge eating associated with weight gain, chronic headaches, and insomnia.
What causes fibromyalgia?While fibromyalgia is regarded as a 'modern disease' it has been around for much longer. The earliest description in the Western literature may be found in the book of Job : "My weary nights are filled with pain as though something were relentlessly gnawing at my bones.".
Take 3 scoops daily with food, or as directed by a qualified health care practitioner.
Mix product well in 1-2 cups of liquid (water, juice, etc.) immediately before consumption.
To minimize the risk of gastrointestinal side effects, start with 1/2-1 scoop two to three times per day and slowly increase to effective dose over a 2 week period. Use for a minimum of
- 1 week to see beneficial effects in mood balance,
- 2 weeks for relief of fibromyalgia symptoms
- 2-3 weeks for migraine prophylaxis.
Ensure to adequately hydrate before, during and after exercise. Consult a health care practitioner for use beyond 1 year.
contains per daily serving (3 scoops, ~21 gram)
Magnesium (malate) 500mg
- malic acid 3.5g
L 5-HTP 300mg
active ingredients (D-ribose, malic acid, magnesium, 5-HTP), buffering agent (citric acid)
keep dry and closed at normal room temperature between 15 - 22°C.
keep out of reach of young children
Consult a health care practitioner when pregnant or nursing.
Do not use if you have scleroderma.
Consult a health care practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity including but not limited to L-tryptophan, S-adenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication, or if symptoms persist or worsen with use.
Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes.
Some people may experience drowsiness.
Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness.
Some people may experience diarrhea, nausea, vomiting and abdominal pain.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans