Acetyl-L-carnitine 500mg 120 capsules - the brain-specific carnitine | Jarrow Formulas
Jarrow Formulas Acetyl-L-Carnitine 500mg 120 capsules is a more bioavailable form of L-Carnitine, an amino acid found in high concentration in human brain, nerve, heart, liver and sperm cells. Acetyl L-Carnitine supports energy production by participating in the metabolism of fatty acids in the mitochondria to yield the universal energy molecule ATP. As an antioxidant, Acetyl-L-Carnitine protects neurons from damage caused by superoxide radicals.
• acetylated form of L-Carnitine in veggie capsules
• promotes fatty acid metabolism
• made with Sigma-Tau Biosint L-Carnitine
• brain-specific carnitine: crosses the blood-brain barrier
Biosint is a trademark of Sigma-Tau Industries, S.p.A. Biosint L-Carnitine is manufactured by Sigma-Tau Industries, S.p.A. (Rome, Italy), the pioneer in L-Carnitine science.
Acetyl L-carnitine (ALC) is an ester derivative of the quaternary amino compound, L-carnitine, which possesses a number of biochemical functions. Primarily, L-carnitine is known for its role in transporting fatty acids into the mitochondria where they are used to create adenosine triphosphate (ATP), the energy currency of the human body. Research has shown that carnitine deficiency lowers ATP levels in various tissues, as might be expected, but more importantly that deficiency increases the susceptibility of the human body to fatigue and decreases the rate of recovery following strenuous, physical activity.
Although beneficial to the cell, ingesting simple L-carnitine isn’t necessarily the most efficient way to supplement intracellular levels.
Significant investigations have demonstrated the bioavailability of ALC surpasses that of L-carnitine alone. Along these lines, in vitro experiments indicate that although some ALC is hydrolyzed into L-carnitine during the digestive process, a large percentage of acetylated carnitine remains intact. As evidenced in humans, administration of 2 grams of ALC per day for 50 days increased plasma ALC levels by 43%. Further support comes from labeling studies showing radioactively labeled ALC inside intestinal cells with the original acetyl group still attached. Importantly, these same characteristics that allow absorption and delivery efficiency, in general, may play a special role in relation to the brain.
Stores of ALC are often found to be deficient in individuals with high blood-sugar levels and related oxidative stress.
In double-blind research, patients with suboptimal nerve function related to blood-sugar imbalances experienced improvement after taking 1500-3000 mg of ALC daily for one year. Similarly, it’s been found that supplementation with 1000 mg of ALC two to three times daily promoted nerve comfort in individuals with suboptimal nerve function.
Several controlled clinical studies have found that supplementation with 2-3 grams ALC daily for 6-12 months supports cognitive function in aging patients with poor short-term memory. This seems to be related to the intrinsic antioxidant activity of ALC, but may also result from effects on acetylcholine levels, which the acetyl-donating ability of ALC is known to positively impact.
Other research has shown that ALC supplementation helped support cognition and attention, as compared to placebo, and positive mood. Such cognitive effects may be mechanistically related to ALC’s ability to modulate the release and receptor binding of another neurotransmitter, dopamine.
In the brain, ALC has been found to support antioxidant status in the brain, helping to promote normalized levels of brain energy metabolites, with an additional role in helping to stabilize cell membranes. Ultimately, these brain-centric effects may derive from ALC’s ability to impact carnitine levels in the brain where simple L-carnitine falls short.
Sperm are energy intensive cells needing readily available ATP to power their movement via flagella. Improvements in sperm motility were demonstrated in one placebo-controlled study of ALC.
Participants with poor sperm motility received L-carnitine (3 grams/day), ALC (3 grams/day), a combination of the two (L-carnitine, 2 grams/day; ALC 1 gram/day), or placebo for one month. The ALC and combination groups showed statistically significant results, with those subjects sporting the lowest baseline sperm motility measures benefitting the most.
Ketone Bodies as Fuel
Aside from being a source of L-carnitine and assisting in the shuttling of fatty acids into cells where they can be turned into ATP, ALC can be a source of acetyl groups that facilitate alternate energy production pathways. ALC can help generate ketone bodies that are utilized for energy production when glucose levels are low. There is some evidence that the body may store acetyl groups, by generating ALC from L-carnitine, for this particular reason.
Acetyl-L-Carnitine is an amino acid like compound found in high concentrations in human brain, nerve, liver and sperm cells. Acetyl-L-Carnitine supports energy production by participating in the metabolism of fatty acids in the mitochondria yielding the universal energy molecule ATP. As an antioxidant, Acetyl-L-Carnitine protects neurons from damage caused by superoxide radicals.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Forget about exercising to lose weight: you can't outrun a bad diet!
Set point and holiday weight gain
Leptin, leptin resistance and SIRT1
After demand for resveratrol and pterostilbene went up considerably, due to a remark on tv by a doctor about its' effect on leptin and cardiovascular function, we got a lot of requests to explain how leptin works.
Currently, a major topic in the field of obesity research is the link between obesity and the hormone leptin. Some evidence suggests that obese-prone individuals don’t respond to increasing leptin levels in the same way that non-obese-prone individuals do, which is the reason obesity is now being associated with possible “leptin resistance.” Scientists first discovered leptin in 1994, after years of research focused on hormones that affect body weight and calorie intake. While initially researchers believed the discovery could be used to create powerful weight loss supplements, this has never happened.
How does leptin function in the body and where does the hormone come from? Leptin interacts with areas of the brain that control hunger and eating behavior. The nickname “the starvation hormone” has been given to leptin because levels tend to plummet when someone restricts their calorie intake too much, exercises more and loses body fat. These are all factors involved in what’s called “starvation mode.”
Meanwhile, ghrelin is called a “hunger hormone” that increases your desire to eat.
At your ideal “set point weight,” fat cells produce a given amount of leptin, which maintains the internal energy balance needed for necessary cellular function and proper weight management. In most healthy adults, changes in body weight will trigger changes in leptin, causing appetite to either increase when body fat falls or decrease when body fat rises — although in some susceptible individuals this energy-balance system seems to malfunction.
There’s still a lot to learn about how leptin resistance or decreased sensitivity to leptin’s signals develops, and what can be done to prevent or reverse it. Many experts believe that eating a highly processed diet — especially while also leading a stressful and mostly sedentary lifestyle — is the perfect storm for developing leptin resistance.
Even if someone is genetically susceptible to weight gain or obesity, there’s still a lot they can do to help prevent this from happening, especially eating a nutrient-dense diet, getting enough exercise and taking steps to manage stress.
How to love your body?
With all these standards for beauty, it’s easy to plummet into a spiral of body-hating. Don’t succumb to the pressure! Love your body, no matter what!
Body shaming is, sadly, a trend these days. You have songs that hate on the skinny girls because “real women have curves.” Then you have songs about shaming people who don’t happen to have the body type of a Victoria’s Secret model. We all know that no one is perfect, but there are still some people who insist on telling people how they should look, how they should act, what size they should be, what their hair color should look like.
Everyone has the right to love their own body. Whether you’re skinny, fat, tall, short, missing a limb, dark-skinned, pale-skinned, what have you, every single body in the world deserves to be loved. It’s just a shame that so many people insist on hating on their bodies, simply because they don’t conform to the unrealistic standards set by society.
Health benefits and dangers of intermittent fasting
Last week I explained how the celebration of carnival and the ensueing Lent with a partial fast can have mental health benefits for you.
Fasting is part of almost every single religion because famines are hard to avoid at the end of winter when food stores are at its lowest. Or in hotter climates, when there is a severe drought.
So it made sense to make peace with unavoidable famine espeically when it is short-lived.
But what if I told you that fasting could actually be healthy for you? That is, fasting for a short period of time. This practice has been adopted by an ever growing amount of people, who mostly adopt a method called intermittent fasting.
Intermittent fasting is said to lead to easier fat loss, increased stamina and vigor, improved focus at the gym and at work, and, improved immune health.
Intermittent fasting effectively mimics the eating habits of our ancestors, who did not have access to grocery stores or food around the clock. They would cycle through periods of feast and famine, and modern research shows this cycling produces a number of biochemical benefits. In short, by altering what and when you eat, you can rather dramatically alter how your body operates.
Is Alzheimer’s Disease the same as type 3 diabetes?Alzheimer starves your brain, tangles and twists vital cells, and for decades it has been misrepresented as an untreatable, genetically determined disease. Alzheimer's disease is already an important cause of death in Western Europe and is expected to rise to the top. This devastating illness shares a strong link with another sickness that wreaks havoc on millions of people too: diabetes.
Strength & enduranceIt is not too hard to improve endurance: just put in enough hours doing your favourite endurance sports. Achieving a decent endurance level while maintaining strength is not so easy.
Why? Because the energy needed for both is from competing systems.
Take 1 to 2 capsules per day on an empty stomach or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
acetyl-L-carnitine 500mg †
(from 596 mg acetyl-L-carnitine HCl)
† = Recommended Daily Intake not established
active ingredient (acetyl-L-carnitine), filler (cellulose, vegetable magnesium stearate) , anti-coagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)
keep dry and closed in a cool place, but do NOT refrigerate.
keep out of reach of young children
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans