5-MTHF Methylfolate 400mcg 60 capsules, bio-available folic acid | Jarrow Formulas
Jarrow Formulas Methyl Folate 400mcg with 5-MTHF is the most biologically active form of folic acid.
QUATREFOLIC is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of folic acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier.
Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
In the US, folic acid is classified as vitamin B9, in the NLs it used to be classified as vitamin B11
At the turn of the 20th century, medical wisdom held that folate (vitamin B9) deficiency and anemia were one and the same. Then, in the 1930’s, it was discovered that anemia could be reversed with brewer’s yeast and that folate was the critical component therein, upon isolation from spinach leaves. This is when it was named “folate” (Latin: folium = leaf). A decade later, the first chemotherapy drug, 4-aminopteroic acid (aminopterin), was developed after understanding the action of folate in the body. Then, in the 1960s, scientists discovered that folate deficiency during pregnancy led to neural tube defects, such as spina bifida and anencephaly, in newborns. Folate supplementation during pregnancy has been shown to reduce the risk of neural tube birth defects.
Folic Acid & Folate: Paternal Twins or Distant Cousins?
Folate is a generic name for a naturally occurring family of compounds containing a pteridine ring linked to p-aminobenzoic acid and containing a polyglutamate tail. The folates found in food consist of a partially bioactive mixture of folate polyglutamates, but these tend to readily degrade during harvesting, storage, and food- processing. Up to three-quarters of initial folate activity may be lost. Synthetic folic acid, which is used for fortification, is much more stable because the pteridine ring is not reduced; it also is devoid of the polyglutamate tail.
But concerns have been raised about the potential side effects associated with too much synthetic folic acid intake. In contrast, it is not generally believed that natural folates present such risk even at high levels of intake.
Folate → Dihydrofolate → Tetrahydrofolate ↔ Methylene- THF → Methylfolate (5-MTHF) Bioactive Form
The difference may stem from the biochemical conversion of folic acid to the bioactive form. In humans, the initial reaction is unusually sluggish. It takes place at < 2% the rate as in rats. And just as surprising, the activity of this enzyme can vary amongst humans by 500%. Natural folates, largely avoid this bottleneck since they are already partially on their way toward the bioactive form.
Folate Metabolism Genetics
For the final conversion step from methylene-THF to methylfolate (5-MTHF), roughly 10% of the population has a severe deficiency of the required enzyme. Another 40% convert only a limited amount. For them, folic acid utility is questionable and deficits observable. Homocysteine, a marker of cardiovascular concern, tends to be elevated as methylfolate is critically involved in recycling homocysteine back to methionine. 5-MTHF is also able to cross the blood-brain barrier, where folate status is linked to neurotransmitter levels and cognitive performance.
Quatrefolic ® : 4th Generation Advantages
Since dietary folate easily deteriorates and folic acid is susceptible to bottlenecks and impasses in the conversion to the bioactive form, there’s certainly room for improvement in supplementing this B vitamin. 5-MTHF itself overcomes one shortcoming by providing the bioactive form. While stabilizing the 5-MTHF as the glucosamine salt, unique to this product, leads to gains in both stability and bioavailability.
Methyl Folate (5-MTHF) is the most biologically active form of folate. Quatrefolic ® ((6S)-5-methyltetrahydrofolate glucosamine salt) is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of folic acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier. Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division.
Recommendations for an additional 400 mcg of folate daily were adopted for women who might become pregnant. But it was soon realized that many had difficulty obtaining enough folate, despite high levels being present in dietary sources like, leafy vegetables, legumes, and egg yolks. Mandating folate fortification in the food supply was proposed as a solution.
In 1996, the U.S. Food and Drug Administration (FDA) instituted the requirement that folic acid be added to enriched breads, cereals, flours, corn meals, pastas, rice, and other grain products. According to the Center for Disease Control and Prevention (CDC), the policy of folic acid fortification has decreased the rate of neural tube defects by 25%.
HEALTH CLAIM: Healthful diets with adequate folate may reduce the risk of having a child with a brain or spinal cord defect.
Some supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.
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- any 9+ = -20%!
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- keep out of reach of young children
- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
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Low-dose radiation therapyLast week I listened to a Dutch podcast, which in general discusses news and politics, but for once, talked about low-dose radiatian therapy as a way to treat COVID-19. This made me curious enough that I wanted to find out more about this particular treatment method.
Most of us know at least one person, whos's been treated with high-dose radiation order to get rid of a malignant tumor. It is less well known that low dosages can be used as well and is used in some countries to treat inflammation disorders such as arthritis.
In general, this is met with disbelief as the official point of view is "all radiation is harmful" .
Proof to the contrary
Yet, over 3000 scientific research papers show that low dose irradiation is stimulatory and/or beneficial in a wide variety of microbes, plants, invertebrates, and vertebrates.
What determines attractiveness?
It is generally accepted as common knowledge how women will feel more sexually attracted to masculin men, but will take far more factors into account when they select future spouses, for which they prefer reliable men who will help raise her offspring.
Another assumption is how women will feel most attracted to masculin-looking men at the most fertile phase of their cycle.
In a recent study where women were shown masculinized and feminized faces of the same men, it was concluded that apparently there is no distinct phase in a women's cycle when they feel less or more attracted, but a bigger influence was whether or not they were in a phase of their life in which they desired to have kids.
When hearing about this study, I immediately wondered why they didn't mention attractiveness of body odour?
Would masculin men not also smell differently from feminine men? In a similar vein, they could have modulated a man's own smell by adding perfume that is perceived as masculin or feminine.
Whomever has followed threads on any perfume forum or has watched popular perfume reviews on Youtube will know that one of the most often asked questions by young and inexperienced men is, "what fragrance is a 'panty dropper'?" In other words, will this fragrance make me so irresistible that women will want to have sex with me?"
Why you should combine B12 with BiofolateJarrow Formulas Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, or converted to cysteine by P5P-dependent enzymes. P5P is the biologically active form of vitamin B6.
Natural family planningIn the past week another birth control method came under fire for a brief moment: even the intrauterine device (IUD or coil) with the lowest amount of hormones when compared to the birth control PILL, has an oftentimes negative effect all over the body and is not 'just' effective locally. I was like, "duh, what else were you expecting?" .
Afterwards, the news disasppeared rapidly out of the headlines as of course, what else is to the disposition of a fertile woman, who likes to have sex, but doesn't like to get pregnant? A condom!
Indeed, a condom. But what if you have a steady and reliable partner, who isn't likely to get a STD, then it is quite something to always be using 'that' contraption.
Stronger with folic acidFor a very long time already, women that want to get pregnant, are advised to start taking folic acid or biofolate (the preferred form). Like-wise, seniors have started to take it as well, especially in combination with vitamin B12 in order to reduce homocystein levels.
In a new study it was concluded, folates give seniors stronger muscles too!
Homocysteine: the real culpritFor the longest time we have been led to believe having a high cholesterol diet is dangerous for our health. This assumption was based on research done by Ancel Keys, who compared diets in seven hand-picked countries and concluded a diet low in animal fats (and cholesterol) was best for cardiovascular health.
This assumption started the war on saturated fats and cholesterol in the mid-1950s Soon doctors around the world were promoting a low fat, low cholesterol diet.
For the next three decades, millions of people gave up butter for margarine, drank low fat milk and diminished their egg intake.
Take 1 capsule per day with food, or as directed by your qualified health care consultant.
contains per daily serving (1 capsule)
methylfolate (QUATREFOLIC® ) 400mcg (100% RDI)
- as (6S)-5-methyltetrahydrofolic acid glucosamine salt
RDI = Recommended Daily Intake
active ingredient (methylfolate), filler (cellulose, vegetable magnesium stearate) , capsule (hydroxypropylmethylcellulose)
store in a cool, dry place
keep out of reach of young children
NOTE: The elderly should frequently check B12 status; use of folic acid may mask pernicious anemia.
If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially antiepileptic and chemotherapy medications), consult your health care practitioner before using this product.
contains no familiar allergens (wheat, gluten, soy, lupin, nuts/tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)
suitable for vegetarians and vegans