5-HTP 50mg 90 capsules - 5-hydroxytryptophan from Griffonia simplicifolia | Jarrow Formulas

5-HTP 50mg 90 capsules - 5-hydroxytryptophan from Griffonia simplicifolia

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Jarrow formulas 5-HTP 50mg (5-Hydroxytryptophan) is an extract of Griffonia simplicifolia seeds from coastal WestAfrica. 
5-HTP is the direct metabolic precursor of serotonin and is important for the production of melatonin.

key benefits
• pure HPLC verified supplement
• instant gratification
• reduces carb cravings

who can benefit from 5-HTP?
Those seeking to support serotonin synthesis, especially those who have previously used L-tryptophan for serotonin support without success, may benefit from using 5-HTP.

background reading

5-Hydroxytryptophan (5-HTP) is an amino acid naturally produced by the body from the essential amino acid L-tryptophan. 5-HTP is the immediate precursor to serotonin (5-hydroxytryptamine, 5-HT) and also a precursor to melatonin. In the brain, serotonin and melatonin help regulate sleep, mood, temperature, and appetite. As such, 5-HTP and L-tryptophan are often taken as supplements to support these roles.

Yet, even though L-tryptophan can be transformed into 5-HTP in the body, the two should not be considered interchangeable for supplement use. The conversion of tryptophan to 5-HTP is the rate- limiting step in neurotransmitter production, and L-tryptophan is utilized for a variety of other purposes in the body, leading to less serotonin support than may be assumed. In purified form, human beings have been consuming 5-HTP for over forty years.

5-HTP vs. L-Tryptophan
The body uses L-tryptophan for other metabolic purposes besides serotonin and melatonin production. For example, L-tryptophan is incorporated into proteins and also acts as a precursor in niacin biosynthesis. L-tryptophan absorption in the intestines requires a shared amino acid transporter, meaning that competition with other amino acids from dietary sources can lead to poor L-tryptophan absorption. A similar specific, active transport mechanism is required for L-tryptophan entry into the brain. A number of other physiological and biochemical parameters, such as stress, insulin response, and vitamin B6 levels can conspire to prevent L-tryptophan from becoming serotonin.

In contrast, 5-HTP is not incorporated into proteins and cannot be used to produce niacin. 5-HTP does not require an intestinal transporter for absorption and is absorbed well even in the presence of other amino acids from food, with about 70 percent of that ingested ending up in the bloodstream. Also, since 5-HTP participates in fewer biosynthetic pathways, it is inherently less susceptible to metabolic diversion. The only hindrance of importance for ingested 5-HTP is the activity of peripheral decarboxylase enzymes, which can convert 5-HTP to serotonin before crossing the blood-brain barrier. However, the results observed in 5-HTP research demonstrate that this is not a major concern.

5-HTP Brain Research
Tryptophan supplements have demonstrated benefits for supporting serotonin levels and mood in specific instances, such as with PMS, seasonal changes, and when dieting. Nevertheless, the serving sizes required are often large. The quantities of 5-HTP found to be useful are typically smaller than those of L-tryptophan. Perhaps, more importantly, 5-HTP impacts the levels of other neurotransmitters besides serotonin, such as dopamine and norepinephrine, without acting as a precursor for their synthesis. 5-HTP has been found to support a positive outlook in a number of studies in human beings starting at daily intake levels as low as 50 mg/day.

5-HTP may also be useful in promoting sleep quality by enhancing REM sleep. One study evaluated the rapid eye movements of volunteers after they ingested 200 mg of 5-HTP at 9:15 pm, followed by 400 mg at 11:15 pm. There was a net positive effect on sleep quality, but the large quantities also seemed to increase the incidence of vivid dreams and nightmares in some volunteers. However, another study used 200 mg/day and found positive effects on sleep quality without the concomitant reports of nightmares.

Serotonin & The Second Brain
Some now use the phrase “our second brain” to refer to the impact our digestive tract can have on the entire body. An example of this is the gut-brain axis, which involves extensive bidirectional signaling and feedback between gut and brain. For anyone who has attempted to diet in the past, this may already be understood experientially.

Serotonin plays a significant, yet not completely understood role in the human digestive tract and gut-brain axis. In fact, research demonstrates 5-HTP may even affect leptin, which helps to regulate energy intake and appetite. Such a connection may help explain results in overweight individuals who were able to exert much better control over their diets when taking 5-HTP.

Purity is assured by HPLC. 5-HTP is verified to be free of the "peak X" contaminant.


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  • keep out of reach of young children
  • a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose
  • if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.
  • books, probiotics and products bought in the SALE can NOT be returned

Snacking late at night: a habit you should embrace rather than be embarrassed about!

One of the most persistent food myths that are still lingering around and is almost universally believed, is how eating late at night is bad for you: you will gain fat, sleep poorly and suffer from gastric distress.
Since the early 2000s I grew accustomed to eating a late night meal of dairy protein before going to bed because it helped me to fall asleep more easily, especially after strenuous exercise in daytime. 
My partner would not eat that very same meal  before regular bedtime, but eat it after waking up after his first sleep cycle at around 3-4am.  
While both of us used to stick to quark in the past due to its higher protein content , we now prefer yoghurt because of the live probiotics in it, and may add extra protein powder to raise its protein content when we aren't eating skyr yoghurt. 
Since starting on this habit I've been annoyed by hearing this perpetual nonsense and would love to put this myth at rest. 
 Whether or not eating late at night is good for you or not depends on the quantity and quality of the food you eat eating throughout the day. 
Most people who do snack at night, don't make healthy choices, and go for that tub of ice cream, that bar of chocolate or bag of crisps, which is why eating late at night got such a bad reputation.
However, time doesn’t really matter. 

Influence of the moon on our behaviour

For the longest time, people have felt the influence of the (full) moon on their behaviour.
Especially on cloudless nights, many of us feel an urge to go outside and enjoy watching the full moon. Some will even go so far that they will go on a nightly hike or bike ride.
If this urge still persists today, how influential must the moon it have been in the past when we only could rely on light of the sun, moon and fire?

This is why so many people believe how lunar cycles can and do influence many other aspects of our behaviour and health.
The most persistent one is about its influence on menstruation cycles, fertility and even on the gender of babies. It's not too difficult to understand where this belief comes from: after all, a lunar cycle is almost as long as the average menstruation cycle.

However, until recently, scientists haven't been able to confirm most of the claims.
Only a short while ago it was confirmed how indeed, the full moon does have an impact on the length of our sleep. Even those who live in an urbanized environment, feel the effect of the full moon on their sleep cycle, even though it is far less pronounced than for indigenous people living without artificial light.

About time to explore whether the moon cycle really affects other aspects of our health and/or behaviour.

Feeling sad and stressed due to COVID-lockdown?

Depression in winter time is quite normal, because we aren't exposed to the vitamin D-generating sunrays, which also enhances immunity levels. Fortunately, we can take vitamin D supplements to combat seasonal depression as well as enhance immunity levels.

Another way to chase sadness away is by celebrating, no matter whether that's Sinterklaas, Winter Solstice, Hanukkah, Christmas or New Year. We will decorate our houses, exchange gifts and overeat , get a bit tipsy and enjoy ourselves.
This year is different: restaurants, shops and even gyms need to close down and we are not allowed to gather together in groups. Lack of entertainment, retail therapy and exercise will make it much more difficult to overcome feelings of depression.
It gets worse when you are among those who work in the tourism or entertainment industry and have lost your job as well as most of your income.

For now it is probably best to just accept the current state of affairs and try to console yourself with non-edible goods, such as nice music with a good book, entertaining movie, and aromatherapy (perfume/room fragrances).
And, weather permitting, put on your walking shoes and go for a long walk in the forests or local park.

But perhaps you have been feeling too stressed to enjoy whatever you still can do to relax? Or you were already feeling sad before COVID-19 came along? In that case, DHEA might help.

Skin hunger: why we crave touch

As we are in the midst of the Easter Holiday, we can't help but feel sad. While Mother Nature is showing abundant signs of spring during a period of incredibly sunny weather, we are barely allowed to go outside other than to do what is absolutely necessary. Our gyms have been closed for almost a month now while in some countries, people aren't even allowed to exercise. Not just group exercise, but also to just jump on a bike and go for long rides. 

While couples and families get grumpy from living together in a cramped space, others face different problems: they are living without any companion whatsoever. Therefore it's not a miracle how all of a sudden, pet asylums have been able to 'clear out' their list of unwanted pets. Not just because people have more time at hand to walk a dog (just about the only thing some are allowed to do) but also because they crave the ability to touch a living being, for lack of being able to touch another human.

Somehow, just like the sense of smell is overlooked, this also is true for the sense of touch. Only when we lose it, we crave it. This craving also is called 'touch hunger' or 'skin hunger'.

How to reduce stress with ASMR

Our brain is programmed to stress us. It does that a lot and on just about any subject. Like a lot of behavioral reactions, stress used to be and still is a survival mechanism that our brain used in order to inject alertness when needed. It’s there so we could harness internal resources and spring into action in a matter of seconds when hunted or hunting.

Fortunately for us, we rarely need to spring into action nowadays to avoid a prowling lion. Today, stress is not helpful and is often counter-productive. When stressed, most of us lose focus and are immersed in unpleasant feelings.

In the past, we needed all that “potential energy” when we faced fight or flight situations. It probably saved our lives more than once. Today, this energy still exists in each of us in certain situations; if it is not discharged via some sort of conduit (either physical or of a more neural nature), it slows us down.
That’s why we need to get creative in the way we release stress. We don’t have time to go on a vacation every week; often we even can’t step away from the almighty computer, tablet, or cell phone.

recommended use
Take 1 capsule per day on an empty stomach, or as directed by your qualified health care consultant. DO NOT exceed recommended amount

contains per daily serving (1 capsule)
5-Hydroxytryptophan 50mg †

RDI = Recommended Daily Intake
† = RDI not established

active ingredient (5-HTP, 5-hydroxytryptophan) fillers (cellulose, magnesium stearate from palm oil), anticoagulant (silicon dioxide), capsule (hydroxypropylmethylcellulose)

keep dry and closed at normal room temperature
keep away from young children

If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially SSRIs, MAOs, or sedatives), consult your health care practitioner before using this product.

allergy information
contains no familiar allergens (wheat, gluten, soy, lupin, nuts, tree nuts, celery, mustard, sesame seeds, dairy, egg, fish/shellfish or mollusks)

suitable for vegetarians and vegans

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